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Ligand 9-fluorenol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.112

9-fluorenol + NAD(P)+ = 9-fluorenone + NAD(P)H

285762

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1.1.1.256

fluoren-9-ol + NAD(P)+ = 9H-fluoren-9-one + NAD(P)H

207942, 207944, 94344

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Product in Enzyme-catalyzed Reactions (9 results)

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Show Product (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.2.1

fluorene + H2O2 = 2-hydroxyfluorene + 9-fluorenol + dihydroxylated fluorene + monohydroxylated fluorenone + trihydroxylated fluorene + H2O

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1.11.2.1

fluorene + H2O2 = 9-fluorenone + 2-hydroxyfluorene + 9-fluorenol + dihydroxylated fluorene + monohydroxylated fluorenone + trihydroxylated fluorene + H2O

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1.11.2.1

fluorene + H2O2 = 9-hydroxyfluorene + H2O

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1.11.2.1

3 entries

1.14.12.12

fluorene + NADH + O2 = (3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene + 9-fluorenol + NAD+

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1.14.12.22

fluorene + NAD(P)H + H+ + O2 = 9-fluorenol + ? + NAD(P)+

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1.14.12.22

fluorene + NAD(P)H + H+ + O2 = 9-fluorenone + 9-fluorenol + monohydroxyfluorene + fluorene dihydrodiol + NAD(P)+

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1.14.12.22

fluorene + NAD(P)H + H+ + O2 = 9-hydroxyfluorene + NAD(P)+

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1.14.12.22

fluorene + NAD(P)H + H+ + O2 = 9-fluorenone + 9-fluorenol + monohydroxyfluorene + fluorene dihydrodiol + NAD(P)+

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1.14.12.22

4 entries

1.14.14.1

fluorene + [reduced NADPH-hemoprotein reductase] + O2 = 9-fluorenol + [oxidized NADPH-hemoprotein reductase] + H2O

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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.52

-

712694

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Enzyme Kinetic Parameters

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.13.11.52

1

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IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

94344

9055403

New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101

1997

Casellas, M.; Grifoll, M.; Bayona, J.M.; Solanas, A.M.

Appl. Environ. Microbiol.

63

819-826

207942

1444405

Isolation and characterization of a fluorine-degrading bacterium: Identification of ring oxidation and ring fission products

1992

Grifoll, M.; Casellas, M.; Bayona, J.M.; Solanas, A.M.

Appl. Environ. Microbiol.

58

2910-2917

207944

8300532

Degradation of fluorene by Brevibacterium sp. strain DPO 1361: A novel C-C bond cleavage mechanism via 1,10-dihydro-1,10-dihydrofluoren-9-one

1994

Trentz, S.P.; Engesser, K.H.; Fischer, P.; Knackmuss, H.J.

J. Bacteriol.

176

789-795

285762

4397102

The dehydrogenation of 1-indanol by a soluble oxidoreductase from bovine liver

1971

Billings, R.E.; Sullivan, H.R.; McMahon, R.E.

J. Biol. Chem.

246

3512-3517

712694

20055453

Rational design of indoleamine 2,3-dioxygenase inhibitors

2010

Roehrig, U.F.; Awad, L.; Grosdidier, A.; Larrieu, P.; Stroobant, V.; Colau, D.; Cerundolo, V.; Simpson, A.J.; Vogel, P.; Van den Eynde, B.J.; Zoete, V.; Michielin, O.

J. Med. Chem.

53

1172-1189

Links to other databases for 9-fluorenol

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Show Links (1 entry)

ChEBI

PubChem

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