Ligand 2-naphthoic acid
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Basic Ligand Information
Molecular Structure
C11H8O2
2-naphthoic acid
UOBYKYZJUGYBDK-UHFFFAOYSA-N
2-naphthalene carboxylate, 2-naphthoate, Naphthalene-2-carboxylic acid, naphthoate
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+
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2-naphthaldehyde + NADP+ + H2O = 2-naphthoate + NADPH + H+
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Substrate in Enzyme-catalyzed Reactions (3 results)
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2-naphthoic acid + AH2 + O2 = 5-hydroxy-2-naphthoic acid + A + H2O
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2-naphthoic acid + AH2 + O2 = 7-hydroxy-2-naphthoic acid + A + H2O
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2-naphthoic acid + AH2 + O2 = 8-hydroxy-2-naphthoic acid + A + H2O
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Product in Enzyme-catalyzed Reactions (12 results)
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2-methylnaphthalene + H2O2 = 2-naphthoic acid + monohydroxylated 2-methylnaphthalene + 2-naphthaldehyde + 2-naphthalene-methanol + monohydroxylated 2-naphthaldehyde + monohydroxylated 2-naphthoic acid + monohydroxylated 2-naphthalenemethanol + dihydroxylated 2-naphthalenemethanol + H2O
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+
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2-naphthaldehyde + NADP+ + H2O = 2-naphthoate + NADPH + H+
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+
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2-naphthaldehyde + NAD+ + H2O = naphthalene-2-carboxylic acid + NADH + 2 H+
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2-naphthaldehyde + NAD+ + H2O = 2-naphthalene carboxylate + NADH + H+
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoic acid + NADH
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoic acid + NADH + H+
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2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + 2 H+
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2-naphthaldehyde + H2O + O2 = 2-naphthoic acid + H2O2
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2-naphthaldehyde + H2O + oxidized benzyl viologen = 2-naphthoate + reduced benzyl viologen + H+
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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3D Structure of Enzyme-Ligand-Complex (PDB) (10 results)
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Enzyme Kinetic Parameters
KM Value (1 result)
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0.00024
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apparent Km value, diphosphate buffer, pH 8.1, cofactor NADH
Ki Value (1 result)
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References & Links
Literature References (5)
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Mandelate racemase from Pseudomonas putida. Magnetic resonance and kinetic studies of the mechanism of catalysis
1975
Maggio, E.T.; Kenyon, G.L.; Mildvan, A.S.; Hegeman, G.D.
Biochemistry
14
1131-1139
Molecular specificity of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) for xenobiotic substrates and inhibitors
1994
Duffel, M.W.
Chem. Biol. Interact.
92
3-14
Salivary aldehyde dehydrogenase-Reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method
2008
Wierzchowski, J.; Pietrzak, M.; Szelag, M.; Wroczynski, P.
Arch. Oral Biol.
53
423-428
Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1
2010
Durrant, J.D.; Hall, L.; Swift, R.V.; Landon, M.; Schnaufer, A.; Amaro, R.E.
PLoS Negl. Trop. Dis.
4
e803
Biotechnological production of caffeic acid by bacterial cytochrome P450 CYP199A2
2012
Furuya, T.; Arai, Y.; Kino, K.
Appl. Environ. Microbiol.
78
6087-6094
Links to other databases for 2-naphthoic acid
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