Ligand L-ribulose 5-phosphate

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Basic Ligand Information

Molecular Structure
Picture of L-ribulose 5-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11O8P
L-ribulose 5-phosphate
FNZLKVNUWIIPSJ-CRCLSJGQSA-N
Pathway Source
Pathways
BRENDA
degradation of pentoses
KEGG
Ascorbate and aldarate metabolism, Microbial metabolism in diverse environments, Pentose and glucuronate interconversions
MetaCyc
L-arabinose degradation I, L-ascorbate degradation I (bacterial, anaerobic), L-ascorbate degradation II (bacterial, aerobic), L-lyxose degradation


Show all pahtways known for Show all BRENDA pathways known for L-ribulose 5-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
L-ribulose 5-phosphate = L-xylulose 5-phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
ATP + L-ribulose = ADP + L-ribulose 5-phosphate
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-
show the reaction diagram
L-ribulose + ATP = L-ribulose 5-phosphate + ADP
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Substrate in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
L-ribulose 5-phosphate = L-xylulose 5-phosphate
-

Product in Enzyme-catalyzed Reactions (4 results)

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EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
ATP + L-ribulose = ADP + L-ribulose 5-phosphate
-
-
show the reaction diagram
ATP + L-ribulose = ADP + L-ribulose 5-phosphate
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (33 results)

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COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
mutant D76N, Zn2+ form of enzyme after dialysis
0.073
-
37°C, pH 7.6, wild-type enzyme
19.4
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, mutant enzyme D76N
0.16
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, mutant enzyme H97N
7.3
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, wild-type enzyme
22.4
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme D76N
0.073
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme H95N
0.047
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme H97N
0.048
-
37°C, pH 7.6, Zn2+-form after dialysis, wild-type
20.4
-
37°C, pH 7.6, wild-type enzyme
1.1
-
mutant D76N, Zn2+ form of enzyme plus 0.1 mM Zn2+
0.16
-
mutant H95N, Zn2+ form of enzyme after dialysis
0.047
-
mutant H95N, Zn2+ form of enzyme plus 0.1 mM Zn2+
0.1
-
mutant H97N, Zn2+ form of enzyme after dialysis
0.048
-
mutant H97N, Zn2+ form of enzyme plus 0.1 mM Zn2+
7.3
-
wild type enzyme, Zn2+ form of enzyme after dialysis
20.4
-
wild type enzyme, Zn2+ form of enzyme plus 0.1 mM Zn2+
20.7
-
22°C, pH 7.5, mutant enzyme H95N, activated by 0.1 mM ZnCl2
0.183
-
37°C, pH 7.6, mutant enzyme N28A
2.5
-
37°C, pH 7.6, mutant enzyme H218N
37°C, pH 7.6, mutant enzyme E142Q
37°C, pH 7.6, mutant enzyme D76E
1
-
37°C, pH 7.6, mutant enzyme D120N
0.0057
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM ZnCl2
17.3
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM MnCl2
36.5
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM MgCl2
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM CoCl2
21.8
-
22°C, pH 7.5, mutant enzyme Y229F, activated by 0.1 mM ZnCl2
0.0118
-
22°C, pH 7.5, mutant enzyme H97N, activated by 0.1 mM ZnCl2

KM Value (29 results)

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COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
37°C, pH 7.6, wild-type enzyme
0.047
-
wild type enzyme, Zn2+ form of enzyme plus 0.1 mM Zn2+
0.06
-
wild type enzyme, Zn2+ form of enzyme after dialysis
0.087
-
mutant H95N, Zn2+ form of enzyme plus 0.1 mM Zn2+
0.096
-
mutant H95N, Zn2+ form of enzyme after dialysis
0.14
-
mutant D76N, Zn2+ form of enzyme after dialysis
0.11
-
L-ribulose 5-phosphate, mutant H97N, Zn2+ form of enzyme after dialysis
0.1
-
L-ribulose 5-phosphate, mutant H97N and D76N, Zn2+ form of enzyme plus 0.1 mM Zn2+
0.14
-
37°C, pH 7.6, Zn2+-form after dialysis, wild-type
0.087
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme H97N
0.14
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme H95N
0.1
-
37°C, pH 7.6, Zn2+-form after dialysis, mutant enzyme D76N
0.11
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, wild-type enzyme
0.06
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, mutant enzyme H97N or D76N
0.14
-
37°C, pH 7.6, Zn2+-form after dialysis + 0.1 mM Zn2+, mutant enzyme H95N
0.096
-
-
0.095
-
37°C, pH 7.6, mutant enzyme N28A
1.2
-
37°C, pH 7.6, mutant enzyme H218N
0.58
-
37°C, pH 7.6, mutant enzyme E142Q
0.086
-
37°C, pH 7.6, mutant enzyme D76E
0.25
-
37°C, pH 7.6, mutant enzyme D120N
0.28
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM ZnCl2
0.0471
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM MnCl2
0.415
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM MgCl2
0.493
-
22°C, pH 7.5, wild-type enzyme, activated by 0.1 mM CoCl2
0.11
-
22°C, pH 7.5, mutant enzyme Y229F, activated by 0.1 mM ZnCl2
0.129
-
22°C, pH 7.5, mutant enzyme H97N, activated by 0.1 mM ZnCl2
0.132
-
22°C, pH 7.5, mutant enzyme H95N, activated by 0.1 mM ZnCl2
0.091
-
-
0.1
-

References & Links

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Links to other databases for L-ribulose 5-phosphate

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ChEBI
PubChem
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PubChem