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Ligand GDP-glucose

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

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Show Natural Substrate (10 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.217

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-glucosyl)-3-phosphoglycerate

736076

-

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

680455

-

2.4.1.269

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

710045

-

2.4.1.347

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

488618

-

2.4.1.36

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

489111, 757195

-

2.7.7.28

GDP-glucose + diphosphate = GTP + D-glucose 1-phosphate

645219, 645220

-

2.7.7.69

GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose

762022

-

2.7.7.78

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP

715612

-

3.2.1.42

GDP-glucose + H2O = GDP + D-glucose

136441

-

3.6.1.9

GDP-glucose + H2O = GMP + D-glucose-1-phosphate

246808

-

Substrate in Enzyme-catalyzed Reactions (46 results)

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Show Substrate (46 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.11

GDP-glucose + (1,4-alpha-D-glucosyl)n = GDP + (1,4-alpha-D-glucosyl)n+1

672646

-

2.4.1.13

GDP-alpha-D-glucose + D-fructose = GDP + sucrose

756234

-

2.4.1.13

GDP-glucose + D-fructose = GDP + sucrose

488551, 488560, 488555, 488547, 488567, 488557, 736101, 735556

-

2.4.1.13

2 entries

2.4.1.14

GDP-glucose + D-fructose 6-phosphate = GDP + sucrose 6-phosphate

659605, 638653

-

2.4.1.15

GDP-alpha-D-glucose + D-glucose 6-phosphate = GDP + alpha,alpha-1,1-trehalose 6-phosphate

702423, 690584

-

2.4.1.15

GDP-alpha-D-glucose + D-glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

658670, 675853, 718977, 727099

-

2.4.1.15

GDP-glucose + D-glucose 6-phosphate = trehalose 6-phosphate + GDP

488607, 488609, 488618, 488597, 488598

-

2.4.1.15

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

727099

-

2.4.1.15

4 entries

2.4.1.217

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-glucosyl)-3-phosphoglycerate

736076

-

2.4.1.220

GDP-glucose + indoxyl = GDP + indican

488950

-

2.4.1.242

GDP-glucose + (1,4-alpha-D-glucosyl)n = GDP + (1,4-alpha-D-glucosyl)n+1

672646

-

2.4.1.242

GDP-glucose + (1,4-alpha-glucosyl)n = GDP + ?

660292

-

2.4.1.245

GDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + GDP

747674, 723675

-

2.4.1.245

GDP-glucose + D-glucose = alpha,alpha-1,1-trehalose + GDP

660897, 662295, 687429

-

2.4.1.245

GDP-glucose + D-glucose = alpha,alpha-trehalose + GDP

722972

-

2.4.1.242

2 entries

2.4.1.245

3 entries

2.4.1.251

GDP-alpha D-glucose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol = GDP + D-Glc-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol

722357

-

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

732910

-

2.4.1.266

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

692382, 710004, 680455, 759741, 674318

-

2.4.1.266

GDP-glucose + D-3-phosphoglycerate = GDP + 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate

680490

-

2.4.1.266

3 entries

2.4.1.268

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

680490

-

2.4.1.269

GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP

723506, 710045

-

2.4.1.29

GDP-glucose + (1,4-beta-D-glucosyl)n = GDP + (1,4-beta-D-glucosyl)n+1

489037, 489038

-

2.4.1.315

GDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP

639551

-

2.4.1.338

GDP-alpha-D-glucose + validoxylamine A = GDP + validamycin A

738038

-

2.4.1.347

GDP-alpha-D-glucose + D-glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

742432, 675853, 687429

-

2.4.1.347

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

488618

-

2.4.1.347

2 entries

2.4.1.35

GDP-glucose + p-nitrophenol = GDP + p-nitrophenyl beta-D-glucoside

489101

-

2.4.1.36

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

489113, 489111, 757195

-

2.4.1.384

GDP-alpha-D-glucose + 3-hydroxyflavone = GDP + 3-hydroxyflavone 3-O-beta-D-glucoside

760383

-

2.4.1.91

GDP-glucose + quercetin = GDP + quercetin 3-O-beta-D-glucoside

673320

-

2.7.1.191

GDP-D-glucose + Glcbeta1,3-GalNAc-PP-CPh = ?

760265

-

2.7.6.4

dATP + GDP-glucose = dAMP + ?

645215

-

2.7.7.13

GDP-glucose + diphosphate = D-glucose 1-phosphate + GTP

642865

-

2.7.7.28

GDP-glucose + diphosphate = GTP + D-glucose 1-phosphate

645219, 645220

-

2.7.7.69

GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose

762022

-

2.7.7.69

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP

692994, 693081

-

2.7.7.69

2 entries

2.7.7.78

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP

715612

-

2.7.7.9

diphosphate + GDP-glucose = GTP + alpha-D-glucose 1-phosphate

643743, 643745, 643748, 643752

-

3.2.1.42

GDP-glucose + H2O = GDP + D-glucose

136441

-

3.6.1.13

GDP-glucose + H2O = GMP + glucose

209946

-

3.6.1.13

GDP-glucose + H2O = GMP + glucose 5-phosphate

655991

-

3.6.1.13

2 entries

3.6.1.21

GDP-Glc + H2O = GMP + Glc-1-phosphate

209944

-

3.6.1.45

GDP-glucose + H2O = GMP + alpha-D-glucose 1-phosphate

696080

-

3.6.1.45

GDP-glucose = GMP + glucose 1-phosphate

209944

-

3.6.1.45

2 entries

3.6.1.52

GDP-glucose + H2O = ?

712171

-

3.6.1.9

GDP-glucose + H2O = GMP + D-glucose-1-phosphate

246808, 246809

-

Product in Enzyme-catalyzed Reactions (13 results)

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Show Product (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.13

GDP + sucrose = GDP-alpha-D-glucose + D-fructose

-

-

2.4.1.245

alpha,alpha-trehalose + GDP = GDP-alpha-D-glucose + D-glucose

-

-

2.7.7.13

GTP + alpha-D-glucose 1-phosphate = alpha-GDP-glucose + diphosphate

-

-

2.7.7.13

GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose

-

-

2.7.7.24

GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-alpha-D-glucose

-

-

2.7.7.24

GTP + alpha-D-glucose 1-phosphate = GDP-glucose + diphosphate

-

-

2.7.7.13

2 entries

2.7.7.24

2 entries

2.7.7.27

GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose

-

-

2.7.7.30

GTP + D-glucose 1-phosphate = diphosphate + GDP-glucose

-

-

2.7.7.34

GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose

643243, 643244,

-

2.7.7.69

alpha-D-glucose 1-phosphate + GDP = GDP-alpha-D-glucose + phosphate

-

-

2.7.7.71

D-glucose 1-phosphate + GTP = GDP-D-glucose + diphosphate

-

-

2.7.7.9

GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-alpha-D-glucose

-

-

2.7.7.91

ATP + D-glucose 1-phosphate = diphosphate + GDP-D-glucose

-

-

Activator in Enzyme-catalyzed Reactions (4 results)

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Show Activating Compound (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.39

about half as effective as UDPglucose, in concentrations exceeding UDPxylose

488687

-

2.4.2.39

activation

489821, 488687

-

2.4.2.39

protection

489821

-

2.4.2.39

3 entries

3.1.3.12

activates 3.6% at 5 mM

658670

-

Inhibitor in Enzyme-catalyzed Reactions (26 results)

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Show Inhibitors (26 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.132

25% inhibition at 1 mM

285830

-

2.4.1.1

-

488241

-

2.4.1.1

0.05 mM, 50% inhibition, competitive inhibition of phosphorolysis

488245

-

2.4.1.1

kinetics

488242

-

2.4.1.1

3 entries

2.4.1.132

-

636752

-

2.4.1.139

strong

488583

-

2.4.1.142

-

636889, 636890

-

2.4.1.144

competitive against UDP-N-acetyl-D-glucosamine

638225

-

2.4.1.15

noncompetitive to UDPglucose

488607

-

2.4.1.152

-

349725

-

2.4.1.173

20% of inhibition at high concentration

637776

-

2.4.1.32

-

489050

-

2.4.1.32

competitive

489048, 489049, 489051

-

2.4.1.32

2 entries

2.4.1.68

-

680034

-

2.4.1.83

0.01 mM, 50% inhibition

489440

-

2.4.2.39

weak

488690

-

2.7.7.12

-

722427

-

2.7.7.13

2.5 mM, 50% inhibition

642873

-

2.7.7.13

inhibition of GDP-mannose phosphorolysis

642865

-

2.7.7.13

2 entries

3.1.4.40

competitive, 83% inhibition

135474

-

3.6.1.45

competitive

209944

-

4.2.1.47

35% inhibition

5728

-

4.2.1.47

Ki: 0.084 mM

5729

-

4.2.1.47

up to 34% inhibition

5733

-

4.2.1.47

3 entries

5.1.3.18

potent competitive inhibitor

652482

-

5.1.3.6

-

653259

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (9 results)

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Show Turnover Number (9 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.1.245

0.54

-

pH 6.0, 60°C

723675

2.4.1.245

34

-

pH 6.0, 60°C

747674

2.4.1.269

0.63

-

pH 7.8, 25°C, cosubstrate: D-glycerate

710045

2.4.1.269

1.1

-

pH 7.8, 25°C, cosubstrate: D-glycerate

710045

2.4.1.245

2 entries

2.4.1.269

2 entries

2.4.1.36

139

-

pH and temperature not specified in the publication

757195

2.7.7.69

9.9

-

pH 7.5, 26°C

693081

2.7.7.69

23

-

pH 7.5, 26°C

692994, 693081

2.7.7.78

26

-

pH 7.5, 31°C

715612

2.7.7.78

265

-

pH 7.5, 26°C

715612

2.7.7.69

2 entries

2.7.7.78

2 entries

K_M Value (32 results)

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Show KM Value (32 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.11

3.9

-

80°C, pH 5.0

672646

2.4.1.14

1.5

-

pH 8.0, enzyme expressed in Escherichia coli

659605

2.4.1.14

2.4

-

pH 8.0, enzyme expressed in Nicotiana tabacum

659605

2.4.1.15

0.4

-

37°C, pH 5.5

675853

2.4.1.15

1

-

in absence or presence of a polyanion

488607

2.4.1.15

2.17

-

pH 8.5, 37°C

702423

2.4.1.15

16

-

-

488618

2.4.1.14

2 entries

2.4.1.15

4 entries

2.4.1.217

1.21

-

pH 7.0-8.0, 70-75°C

736076

2.4.1.242

3.9

-

-

672646

2.4.1.245

1.7

-

pH 6.0, 60°C

747674

2.4.1.245

2.08

-

pH 6.0, 60°C

723675

2.4.1.266

1.75

-

pH 7.6, 30°C

680455

2.4.1.266

3.7

-

pH 7.6, 50°C

680455

2.4.1.266

27.7

-

pH 7.5, 37°C

692382

2.4.1.266

32.04

-

pH 7.5, 37°C

692382

2.4.1.245

2 entries

2.4.1.266

4 entries

2.4.1.268

7.1

-

pH 6.5, 70°C

680490

2.4.1.269

124.9

-

pH 7.8, 25°C, cosubstrate: D-glycerate

710045

2.4.1.269

138.6

-

pH 7.8, 25°C, cosubstrate: D-glycerate

710045

2.4.1.347

0.4

-

37°C, pH 5.5

675853

2.4.1.347

0.7

-

37°C

687429

2.4.1.347

16

-

at pH 8.0 and 37°C

742432

2.4.1.347

16

-

-

488618

2.4.1.269

2 entries

2.4.1.347

4 entries

2.4.1.36

0.12

-

pH and temperature not specified in the publication

757195

2.7.7.28

0.62

-

pH 7.8, 25°C

645219

2.7.7.34

0.1

-

pH 7.4, 30°C

643243

2.7.7.69

0.0044

-

pH 7.5, 26°C

692994, 693081

2.7.7.69

0.012

-

pH 7.5, 26°C

693081

2.7.7.78

0.002

-

pH 7.5, 31°C

715612

2.7.7.78

0.01

-

pH 7.5, 26°C

715612

2.7.7.69

2 entries

2.7.7.78

2 entries

3.2.1.42

0.23

-

-

136441

3.6.1.21

40

-

same Km for GDP-Glc and GDP-Man

209944

3.6.1.45

0.11

-

-

209944

K_i Value (9 results)

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Show KI Value (9 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.1

0.02

-

-

488241

2.4.1.1

0.03

-

-

488242

2.4.1.1

2 entries

2.4.1.144

1

-

recombinant enzyme

638225

2.4.1.152

0.38

-

-

349725

2.4.1.32

0.001

-

digitonin-solubilized enzyme

489051

2.4.1.32

0.006

-

-

489051

2.4.1.32

2 entries

2.4.1.68

0.36

-

-

680034

2.7.7.13

11

-

pH 7.5, 37°C

642865

4.2.1.47

0.084

-

-

5729

References & Links

Literature References (104)

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Show Reference (104 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

5728

4076184

Purification and characterization of GDP-D-mannose 4,6 dehydratase from porcine thyroid

1985

Broschat, K.O.; Chang, S.; Serif, G.

Eur. J. Biochem.

153

397-401

5729

5047712

Purification of guanosine 5'-diphosphate d-mannose oxidoreductase from Phaseolus vulgaris

1972

Liao, T.H.; Barber, G.A.

Biochim. Biophys. Acta

276

85-93

5733

9257704

Expression, purification and characterization of GDP-D-mannose 4,6,-dehydratase from Escherichia coli

1997

Sturla, L.; Bisso, A.; Zanardi, D.; Benatti, U.; De Flora, A.; Tonetti, M.

FEBS Lett.

412

126-130

135474

4372219

Cytidine 5-monophosphosialic acid hydrolase. Subcellular location and properties

1974

Kean, E.L.; Bighouse, K.J.

J. Biol. Chem.

249

7813-7823

136441

5963308

Guanosine diphosphate D-glucose glucohydrolase

1966

Sonnino, S.; Carminatti, H.; Cabib, E.

Arch. Biochem. Biophys.

116

26-33

209944

5337593

Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor

1967

Glaser, L.; Melo, A.; Paul, R.

J. Biol. Chem.

242

1944-1954

209946

10567213

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif

1999

Gasmi, L.; Cartwright, J.L.; McLennan, A.G.

Biochem. J.

344

331-337

246808

12228543

Purification and properties of a unique nucleotide pyrophosphatase/phosphodiesterase I that accumulates in soybean leaves in response to fruit removal

1995

Salvucci, M.E.; Crafts-Brandner, S.J.

Plant Physiol.

108

1269-1276

246809

9453136

Characterization of H. parasuis periplasmic nucleotide pyrophosphatase as a potential target enzyme for inhibition of growth

1997

Wise, D.J.; Anderson, C.D.; Anderson, B.M.

Vet. Microbiol.

58

261-276

285830

2470755

Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa

1989

Roychoudhury, S.; Mmay, T.B.; Gill, J.F.; Singh, S.K.; Feingold, D.S.; Chakrabarty, A.M.

J. Biol. Chem.

264

9380-9385

349725

8780523

Mechanism and specificity of human alpha-1,3-fucosyltransferase V

1996

Murray, B.W.; Takayama, S.; Schultz, J.; Wong, C.H.

Biochemistry

35

11183-11195

488241

4157120

Mobilization of granulose in Clostridium pasteurianum. Purification and properties of granulose phosphorylase

1974

Robson, R.L.; Morris, J.G.

Biochem. J.

144

513-517

488242

527584

1,4-alpha-Glucan phosphorylase from the slime mold Physarum polycephalum. Purification, physico-chemical and kinetic properties

1979

Nader, W.; Becker, J.U.

Eur. J. Biochem.

102

345-355

488245

-

Glycogen phosphorylase in Dictyostelium discoideum. I. Purification and properties of the enzyme

1976

Thomas, D.A.; Wright, B.E.

J. Biol. Chem.

254

1253-1257

488547

-

Purification of sucrose synthase from rice and its protein-chemical characterization

1993

Elling, L.; Kula, M.R.

J. Biotechnol.

29

277-286

488551

4624446

The purification and properties of sucrose synthetase from etiolated Phaseolus aureus seedlings

1972

Delmer, D.P.

J. Biol. Chem.

247

3822-3828

488555

16664189

Sucrose synthase of soybean nodules

1985

Morell, M.; Copeland, L.

Plant Physiol.

78

149-154

488557

-

Sucrose synthetase from triploid quaking aspen callus

1978

Graham, L.L.; Johnson, M.A.

Phytochemistry

17

1231-1233

488560

16653008

Purification and characterization of sucrose synthase from the cotyledons of Vicia faba L.

1992

Ross, H.A.; Davies, H.V.

Plant Physiol.

100

1008-1013

488567

10592030

Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence

1999

Porchia, A.C.; Curatti, L.; Salerno, G.L.

Planta

210

34-40

488583

24275923

Characterization of maltose biosynthesis from alpha-D-gluccose-1-phosphate in Spinacia oleracea L.

1982

Schilling, N.

Planta

154

87-93

488597

159657

Trehalose 6-phosphate synthase from Dictyostelium discoideum: partial purification and characterization of the enzyme from young sorocarps

1979

Killick, K.A.

Arch. Biochem. Biophys.

196

121-133

488598

-

Kinetic and biological properties of trehalose phosphate synthase from Neurospora crassa

1975

Betz, R.; Holldorf, A.W.

Biochem. Soc. Trans.

3

988-989

488607

-

Properties of a trehalose phosphate synthetase from Mycobacterium smegmatis

1971

Lapp, D.; Patterson, B.W.; Elbein, A.D.

J. Biol. Chem.

246

4567-4579

488609

8914922

Inhibition of the trehalose-P synthase of mycobacteria by various antibiotics

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