Ligand GDP-glucose

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of GDP-glucose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H25N5O16P2
GDP-glucose
MVMSCBBUIHUTGJ-LRJDVEEWSA-N
Synonyms:
alpha-GDP-glucose, GDP-alpha-D-glucose, GDP-alpha D-glucose, GDP-D-glucose, GDP-Glc, GDPglucose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-glucosyl)-3-phosphoglycerate
show the reaction diagram
-
GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
-
GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP
show the reaction diagram
-
GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
GDP-glucose + diphosphate = GTP + D-glucose 1-phosphate
show the reaction diagram
-
GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
show the reaction diagram
-
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP
show the reaction diagram
-
GDP-glucose + H2O = GDP + D-glucose
show the reaction diagram
-
GDP-glucose + H2O = GMP + D-glucose-1-phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-glucose + (1,4-alpha-D-glucosyl)n = GDP + (1,4-alpha-D-glucosyl)n+1
show the reaction diagram
-
GDP-glucose + D-fructose 6-phosphate = GDP + sucrose 6-phosphate
show the reaction diagram
-
GDP-glucose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-glucosyl)-3-phosphoglycerate
show the reaction diagram
-
GDP-glucose + indoxyl = GDP + indican
show the reaction diagram
-
GDP-alpha D-glucose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol = GDP + D-Glc-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol
show the reaction diagram
-
GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP
show the reaction diagram
-
GDP-alpha-D-glucose + D-glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + GDP
show the reaction diagram
-
GDP-glucose + (1,4-beta-D-glucosyl)n = GDP + (1,4-beta-D-glucosyl)n+1
show the reaction diagram
-
GDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
show the reaction diagram
-
GDP-alpha-D-glucose + validoxylamine A = GDP + validamycin A
show the reaction diagram
-
GDP-glucose + p-nitrophenol = GDP + p-nitrophenyl beta-D-glucoside
show the reaction diagram
-
GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate
show the reaction diagram
-
GDP-alpha-D-glucose + 3-hydroxyflavone = GDP + 3-hydroxyflavone 3-O-beta-D-glucoside
show the reaction diagram
-
GDP-glucose + quercetin = GDP + quercetin 3-O-beta-D-glucoside
show the reaction diagram
-
GDP-D-glucose + Glcbeta1,3-GalNAc-PP-CPh = ?
show the reaction diagram
-
dATP + GDP-glucose = dAMP + ?
show the reaction diagram
-
GDP-glucose + diphosphate = D-glucose 1-phosphate + GTP
show the reaction diagram
-
GDP-glucose + diphosphate = GTP + D-glucose 1-phosphate
show the reaction diagram
-
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP
show the reaction diagram
-
diphosphate + GDP-glucose = GTP + alpha-D-glucose 1-phosphate
show the reaction diagram
-
GDP-glucose + H2O = GDP + D-glucose
show the reaction diagram
-
GDP-Glc + H2O = GMP + Glc-1-phosphate
show the reaction diagram
-
GDP-glucose + H2O = ?
show the reaction diagram
-
GDP-glucose + H2O = GMP + D-glucose-1-phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP + sucrose = GDP-alpha-D-glucose + D-fructose
show the reaction diagram
-
-
alpha,alpha-trehalose + GDP = GDP-alpha-D-glucose + D-glucose
show the reaction diagram
-
-
GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose
show the reaction diagram
-
-
GTP + D-glucose 1-phosphate = diphosphate + GDP-glucose
show the reaction diagram
-
-
GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-glucose
show the reaction diagram
-
alpha-D-glucose 1-phosphate + GDP = GDP-alpha-D-glucose + phosphate
show the reaction diagram
-
-
D-glucose 1-phosphate + GTP = GDP-D-glucose + diphosphate
show the reaction diagram
-
-
GTP + alpha-D-glucose 1-phosphate = diphosphate + GDP-alpha-D-glucose
show the reaction diagram
-
-
ATP + D-glucose 1-phosphate = diphosphate + GDP-D-glucose
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates 3.6% at 5 mM
-

Inhibitor in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
25% inhibition at 1 mM
-
strong
-
competitive against UDP-N-acetyl-D-glucosamine
-
noncompetitive to UDPglucose
-
20% of inhibition at high concentration
-
0.01 mM, 50% inhibition
-
weak
-
competitive, 83% inhibition
-
competitive
-
potent competitive inhibitor
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
139
-
pH and temperature not specified in the publication

KM Value (32 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.9
-
80°C, pH 5.0
1.21
-
pH 7.0-8.0, 70-75°C
3.9
-
-
7.1
-
pH 6.5, 70°C
0.12
-
pH and temperature not specified in the publication
0.62
-
pH 7.8, 25°C
0.1
-
pH 7.4, 30°C
0.23
-
-
40
-
same Km for GDP-Glc and GDP-Man
0.11
-
-

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1
-
recombinant enzyme
0.38
-
-
0.36
-
-
11
-
pH 7.5, 37°C
0.084
-
-

References & Links

Links to other databases for GDP-glucose

ChEBI
PubChem
-
PubChem