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Ligand 8-methylguanine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.6

deoxycytidine + C8-methylguanine = cytosine + 2'-deoxy-8-methylguanosine

638054

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Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

8-methylguanosine + phosphate = 8-methylguanine + alpha-D-ribose 1-phosphate

0

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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.15

-

759069

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Enzyme Kinetic Parameters

References & Links

Literature References (2)

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BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

638054

8902269

Addition of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase

1996

Mueller, M.; Hutchinson, L.K.; Guengerich, F.P.

Chem. Res. Toxicol.

9

1140-1144

759069

29171692

8-Mercaptoguanine derivatives as inhibitors of dihydropteroate synthase

2018

Dennis, M.L.; Lee, M.D.; Harjani, J.R.; Ahmed, M.; DeBono, A.J.; Pitcher, N.P.; Wang, Z.C.; Chhabra, S.; Barlow, N.; Rahmani, R.; Cleary, B.; Dolezal, O.; Hattarki, M.; Aurelio, L.; Shonberg, J.; Graham, B.; Peat, T.S.; Baell, J.B.; Swarbrick, J.D.

Chemistry

24

1922-1930

Links to other databases for 8-methylguanine

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ChEBI

PubChem

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