Ligand deoxyinosine

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Basic Ligand Information

Molecular Structure
Picture of deoxyinosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12N4O4
deoxyinosine
VGONTNSXDCQUGY-RRKCRQDMSA-N
Synonyms:
2'-deoxy-inosine, 2'-deoxyinosine, 7-(beta-D-2'-deoxyribufuranosyl)hypoxanthine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-6-ol


Show all pahtways known for Show all BRENDA pathways known for deoxyinosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dIMP + H2O = deoxyinosine + phosphate
show the reaction diagram
-
-
2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
deoxyinosine + O2 = 9-riburonosyldeoxyhypoxanthine + H2O
show the reaction diagram
-
ATP + 2'-deoxyinosine = ADP + 2'-deoxyinosine 5'-phosphate
show the reaction diagram
-
ATP + deoxyinosine = ADP + dIMP
show the reaction diagram
-
4-nitrophenyl phosphate + 2'-deoxyinosine = 4-nitrophenol + 2'-deoxyinosine 5'-phosphate
show the reaction diagram
-
2'-deoxyinosine + H2O = hypoxanthine + 2-deoxy-D-ribose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hypoxanthine + alpha-D-deoxyribose 1-phosphate = deoxyinosine + phosphate
show the reaction diagram
-
-
5'-dIMP + H2O = deoxyinosine + phosphate
show the reaction diagram
-
-
deoxyadenosine + H2O = deoxyinosine + NH3
show the reaction diagram
-
-
2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak, competitive
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (15 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.8
-
full-length enzyme, at pH 7.8 and 37°C

KM Value (36 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.5
-
full-length enzyme, at pH 7.8 and 37°C
0.0057
-
pH 7.5, 37°C, reaction with 4-nitrophenyl phosphate

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.5
-
-
0.34
-
-
0.075
-
pH 7.4, 37°C, competitive vs. deoxyguanosine, mitochondrial deoxyguanosine kinase

References & Links

Links to other databases for deoxyinosine

ChEBI
PubChem
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PubChem