Ligand corticosterone

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Basic Ligand Information

Molecular Structure
Picture of corticosterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H30O4
corticosterone
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Synonyms:
4-pregnen-11beta,21-diol-3,20-dione, 4-pregnene-11beta,21-diol-3,20-dione, 11beta,21-dihydroxy-4-pregnen-3,20-dione, 11beta,21-dihydroxy-pregn-4-ene-3,20-dione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
show the reaction diagram
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corticosterone + NADPH = ?
show the reaction diagram
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ATP + H2O + corticosterone/in = ADP + phosphate + corticosterone/out
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11-dehydrocorticosterone + NADPH = corticosterone + NADP+
show the reaction diagram
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ATP + H2O + corticosterone/in = ADP + phosphate + corticosterone/out
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
corticosterone + NADPH = ? + NADP+
show the reaction diagram
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corticosterone + NADPH = ?
show the reaction diagram
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corticosterone + NADP+ = 21-hydroxy-pregn-4-ene-3,11,20-trione + NADPH
show the reaction diagram
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4-pregnen-11beta,21-diol-3,20-dione + NADPH = 4-pregnen-11beta,20alpha,21-triol-3-one + NADP+
show the reaction diagram
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Corticosterone + NADPH + O2 = ?
show the reaction diagram
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corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
show the reaction diagram
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corticosterone + NADPH + H+ = 5alpha-dihydrocorticosterone + NADP+
show the reaction diagram
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3'-phosphoadenylylsulfate + corticosterone = adenosine 3',5'-bisphosphate + corticosterone sulfate
show the reaction diagram
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Corticosterone = 11beta,20-Dihydroxy-3-oxopregn-4-en-21-al
show the reaction diagram
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ATP + H2O + corticosterone/in = ADP + phosphate + corticosterone/out
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADH = 11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
show the reaction diagram
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11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADPH = 11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+
show the reaction diagram
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11beta-hydroxyprogesterone + NADH + O2 = corticosterone + NAD+ + H2O
show the reaction diagram
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ATP + H2O + corticosterone/in = ADP + phosphate + corticosterone/out
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
4fold activation
-
counteracts inhibiting effect of sucrose and increases hypothalamic AMPK activity to levels comparable with saline-drinking animals
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0.5 mM, 18% activation
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.08 mM, 50% inhibition
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i.e. corticosterone
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competitive inhibition of 11beta-hydroxylase activity
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competitive inhibitor, inhibits cortisol sulfotransferase activity
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cortisol as substrate, strong
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0378
-
+/-0.2268, calculatetd from Kcat/Km
0.032
-
pH 6.0, 37°C

KM Value (29 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.095
-
22°C
0.0022
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pH 6.0, 37°C

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.005
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for corticosterone

ChEBI
PubChem
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PubChem