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Ligand baicalein

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.253

UDP-D-glucuronate + 5,6,7-trihydroxyflavone = UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate

706115

-

2.4.1.253

UDP-D-glucuronate + baicalein = UDP + baicalin

759908

-

2.4.1.253

UDP-glucuronate + baicalein = UDP + baicalin

712081

-

2.4.1.253

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.167

baicalin + H2O = baicalein + beta-D-glucuronic acid

0

-

3.2.1.167

baicalin + H2O = baicalein + D-glucuronate

0

-

3.2.1.167

2 entries

Substrate in Enzyme-catalyzed Reactions (11 results)

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Show Substrate (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.104

S-adenosyl-L-methionine + baicalein = ?

758068

-

2.1.1.104

S-adenosyl-L-methionine + baicalein = S-adenosyl-L-homocysteine + ?

757943

-

2.1.1.104

2 entries

2.4.1.104

UDP-glucose + baicalein = UDP + 7-O-glucosylbaicalein

488400

-

2.4.1.170

UDP-glucose + baicalein = UDP + baicalein 7-O-beta-D-glucoside

663180

-

2.4.1.253

UDP-D-glucuronate + 5,6,7-trihydroxyflavone = UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate

706115

-

2.4.1.253

UDP-D-glucuronate + baicalein = UDP + baicalin

759908

-

2.4.1.253

UDP-glucuronate + baicalein = UDP + baicalin

706115, 712081

-

2.4.1.253

3 entries

2.4.1.384

UDP-alpha-D-glucose + baicalein = ? + UDP

760811

-

2.4.1.4

sucrose + baicalein = D-fructose + ?

758175

-

2.4.1.4

sucrose + baicalein = D-fructose + baicalein 6-O-alpha-D-glucopyranoside

756762

-

2.4.1.4

2 entries

2.4.1.81

UDP-glucose + baicalein = UDP + ?

759388

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.167

5,6,7-trihydroxyflavone-7-beta-D-glucuronide + H2O = 5,6,7-trihydroxyflavone + D-glucuronate

0

-

3.2.1.167

5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate + H2O = 5,6,7-trihydroxyflavone + D-glucuronate

0

-

3.2.1.167

baicalin + H2O = baicalein + beta-D-glucuronic acid

0

-

3.2.1.167

baicalin + H2O = baicalein + D-glucuronate

0

-

3.2.1.167

4 entries

3.2.1.31

baicalin + H2O = baicalein + beta-D-glucuronate

0

-

3.2.1.B44

baicalin + H2O = 5,6,7-trihydroxyflavone + D-glucuronate

0

-

Inhibitor in Enzyme-catalyzed Reactions (48 results)

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Show Inhibitors (48 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.25

about 25% inhibition at 0.0025 mM

740771

-

1.1.1.252

affects fungal pigmentation and growth, inhibits by 75%

697274

-

1.1.1.267

-

762667

-

1.1.1.62

-

699839

-

1.1.1.62

i.e. 5,6,7-trihydroxyflavone, 61% inhibition at 0.006 mM

700186

-

1.1.1.62

weak inhibitor with 7.2% inhibition at 0.1 mM

699839

-

1.1.1.64

IC50: 0.0093 mM, reduction of androstenedione

658489

-

1.1.1.64

IC50: 0.18592 mM

667983

-

1.13.11.31

-

686330, 687143, 688759, 690148, 705902, 765751

-

1.13.11.31

12-LOX inhibition attenuates platelet aggregation

728826

-

1.13.11.31

inhibition of 12-LOX enzymatic activity using baicalein inhibits MMP9 expression in PC3 cells

727634

-

1.13.11.31

inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview

684844

-

1.13.11.31

p12-LOX specific inhibitor, suppresses proliferation of JB6 P+ cells when cells are seeded at a low density in a culture plate by 81%

703078

-

1.13.11.31

potent in vitro inhibitor of platelet 12-LOX

712802

-

1.13.11.31

prevents cell death, the 12/15-LOX inhibitor and the proteasome protect against exogenous glutamate, but not by preventing glutathione depletion. LOX inhibition, but not proteasome inhibition, reduces oxidative stress in glutamate-treated HT22 cells. The mitochondrial membrane potential is protected by coinhibition with AA861

705256

-

1.13.11.31

the 12LO inhibitor induces a 2-2.5fold increase in cell death, which appears to result from apoptosis, as indicated by DNA fragmentation, activation of procaspase 3 to caspase 3 and cytochrome c release from the mitochondria to the cytosol. This apoptosis can be prevented by treatment with the 12LO product, 12 hydroxyeicosatetraenoic acid (12HETE)

742456

-

1.13.11.33

-

706877, 742613, 765751

-

1.13.11.33

IC50: 0.001 mM

657880

-

1.13.11.33

IC50: 0.035 mM

657880

-

1.13.11.33

potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100

672543

-

1.13.11.34

IC50: 0.0012 mM

439461

-

1.13.11.34

inhibition of the 5-LO product formation of intact human polymorphonuclear leukocytes, IC50 value 0.0014 mM

764112

-

1.1.1.62

3 entries

1.1.1.64

2 entries

1.13.11.31

8 entries

1.13.11.33

4 entries

1.13.11.34

2 entries

1.13.11.40

-

688221

-

1.13.11.52

uncompetitive reversible potent IDO-1 inhibitor

712230

-

1.14.18.1

5,6,7-trihydroxyflavone, high inhibitory effects on tyrosinase. Acts as a cofactor to monophenolase

689106

-

1.5.1.33

-

764535

-

2.3.1.41

-

736660

-

2.3.1.67

concentration dependent inhibition, IC50: 0.105 mM

487390

-

2.3.1.67

IC50: 0.148 mM

487385

-

2.3.1.67

2 entries

2.3.1.85

50% inhibition at 0.11169 mM

662061

-

2.4.1.1

50% inhibition of phosphorylated, active enzyme at 0.0112 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0102 mM

676090

-

2.4.1.207

-

736955

-

2.4.2.1

72% inhibition at 0.15 mM, reversible inhibition

759341

-

3.1.1.1

-

750021

-

3.1.1.13

-

729673

-

3.1.1.8

an alkaloid isolated from Isatis tinctoria

693392

-

3.2.1.18

-

702681

-

3.2.1.20

-

681559

-

3.2.1.20

16% inhibition at 0.5 mM

681559

-

3.2.1.20

i.e. 5,6,7-trihydroxy flavone, from hexane extracts of the Indian herb Oroxylum indicum

678697

-

3.2.1.20

3 entries

3.3.2.10

36.86% inhibition

753858

-

3.4.11.2

42% inhibition at 0.3 mM

666240

-

3.4.21.5

-

718420

-

3.4.23.1

-

755552

-

4.1.1.31

-

4342

-

4.4.1.5

-

37455

4x2a, 3D-view

4.4.1.5

79% inhibition of rhGLO I at 0.1 mM

691217

4x2a, 3D-view

4.4.1.5

2 entries

5.6.2.1

(5,6,7-trihydroxyflavone), naturally occurring flavone, isolated from the stem-bark of Oroxylum indicum, binds to the free enzyme and also intercalates into the DNA at a very high concentration (300 mM) without binding to the minor grove

682159

-

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (3 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.5.1.18

8a0q, 3D-view

3.4.22.69

6m2n, 3D-view

4.4.1.5

4x2a, 3D-view

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.253

0.0524

-

pH 7.5, 37°C

706115

K_i Value (5 results)

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Show KI Value (5 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.252

0.0054

-

at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C

697274

1.13.11.33

0.00018

-

-

672543

1.13.11.33

0.0011

-

in the presence of 0.01% Triton X-100

672543

1.13.11.33

2 entries

1.13.11.52

0.215

-

pH and temperature not specified in the publication

712230

3.2.1.20

0.5

-

-

678697

IC₅₀ Value (26 results)

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Show IC50 Value (26 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.1.1.252

0.012

-

at 0.04 mM 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one, at pH 7.0 and 25°C

697274

1.1.1.64

0.0093

-

IC50: 0.0093 mM, reduction of androstenedione

658489

1.1.1.64

0.18592

-

IC50: 0.18592 mM

667983

1.13.11.33

0.001

-

IC50: 0.001 mM

657880

1.13.11.33

0.035

-

IC50: 0.035 mM

657880

1.13.11.33

0.038

100

potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100

672543

1.13.11.34

0.00029

-

pH 7.4, 37°C

764112

1.13.11.34

0.0012

-

IC50: 0.0012 mM

439461

1.1.1.64

2 entries

1.13.11.33

3 entries

1.13.11.34

2 entries

1.14.18.1

0.273

-

-

689106

2.3.1.67

0.105

-

concentration dependent inhibition, IC50: 0.105 mM

487390

2.3.1.67

0.148

-

IC50: 0.148 mM

487385

2.3.1.67

2 entries

2.4.1.207

0.52

-

pH 5.5, 20°C

736955

2.4.2.1

0.0894

-

pH 7.4, 37°C

759341

3.1.1.1

0.02112

-

pH 7.4, 37°C

750021

3.1.1.13

0.0123

-

at pH 7.0 and 25°C

729673

3.2.1.18

0.1

-

in 50 mM Tris-HCl pH 7.5, at 25°C

702681

3.2.1.18

0.13

-

in 50 mM Tris-HCl pH 7.5, at 25°C

702681

3.2.1.20

0.2

-

above, pH 6.8, 30°C

681559

3.2.1.20

0.203

-

-

678697

3.2.1.20

0.214

-

-

678697

3.2.1.18

2 entries

3.2.1.20

3 entries

3.3.2.10

0.1

-

above, pH not specified in the publication, 37°C

753858

3.4.21.5

0.06

-

pH and temperature not specified in the publication

718420

3.4.23.1

0.0609

-

at pH 2.0 and 37°C

755552

4.4.1.5

0.011

-

indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0

691217

5.6.2.1

0.0015

-

LdTOP1LS pre-incubated separately with different concentrations for 5 min at 37°C in relaxation buffer followed by addition of pBluescript(SK+) DNA and further incubated for 15 min at 37°C

682159

5.6.2.1

0.009

-

Quantitative representation of enzyme inhibition in the presence of flavones in relaxation experiments

682159

5.6.2.1

2 entries

References & Links

Literature References (62)

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Show Reference (62 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4342

8704306

Flavonoids as inhibitors of NADP-malic enzyme and PEP carboxylase from C4 plants

1996

Pairoba, C.F.; Colombo, S.L.; Andreo, C.S.

Biosci. Biotechnol. Biochem.

60

779-783

37455

-

Effects of substrate- (glutathione-) and inhibitor- (flavonoid-) analogues on glyoxalase I activity

1992

Ito, M.; Sadakane, K.; Shiotsuki, T.; Eto, M.

Biosci. Biotechnol. Biochem.

56

1461-1462

439461

6089906

Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells

1984

Furukawa, M.; Yoshimoto, T.; Ochi, K.; Yamamoto, S.

Biochim. Biophys. Acta

795

458-465

487385

8147919

Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex

1994

Yamazaki, R.; Sugatani, J.; Fujii, I.; Kuroyanagi, M.; Umehara, K.; Ueno, A.; Suzuki, Y.; Miwa, M.

Biochem. Pharmacol.

47

995-1006

487390

9326723

The sensitivity of bovine corneal epithelial lyso-PAF acetyltransferase to cyclooxygenase and lipoxygenase inhibitors is independent of arachidonate metabolites

1997

Hurst, J.S.; Bazan, H.E.P.

J. Ocul. Pharmacol. Ther.

13

415-426

488400

10940474

Purification and characterization of UDP-glucose:hydroxycoumarin 7-O-glucosyltransferase, with broad substrate specificity from tobacco cultured cells

2000

Taguchi, G.; Imura, H.; Maeda, Y.; Kodaira, R.; Hayashida, N.; Shimosaka, M.; Okazaki, M.

Plant Sci.

157

105-112

657880

12628491

Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action

2003

Sadik, C.D.; Sies, H.; Schewe, T.

Biochem. Pharmacol.

65

773-781

658489

12570693

Inhibitors of 17beta-hydroxysteroid dehydrogenases

2003

Poirier, D.

Curr. Med. Chem.

10

453-477

662061

14999013

Inhibitory effects of flavonoids on animal fatty acid synthase

2004

Li, B.H.; Tian, W.X.

J. Biochem.

135

85-91

663180

14523650

cDNA cloning and expression of isoflavonoid-specific glucosyltransferase from Glycyrrhiza echinata cell-suspension cultures

2004

Nagashima, S.; Inagaki, R.; Kubo, A.; Hirotani, M.; Yoshikawa, T.

Planta

218

456-459

666240

16216010

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects

2006

Bauvois, B.; Dauzonne, D.

Med. Res. Rev.

26

88-130

667983

16797984

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3)

2006

Lota, R.K.; Dhanani, S.; Owen, C.P.; Ahmed, S.

Bioorg. Med. Chem. Lett.

16

4519-4522

672543

16500106

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

2006

Deschamps, J.D.; Kenyon, V.A.; Holman, T.R.

Bioorg. Med. Chem.

14

4295-4301

676090

16317787

Natural flavonoids are potent inhibitors of glycogen phosphorylase

2006

Jakobs, S.; Fridrich, D.; Hofem, S.; Pahlke, G.; Eisenbrand, G.

Mol. Nutr. Food Res.

50

52-57

678697

18255289

Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors

2008

Hari Babu, T.; Rama Subba Rao, V.; Tiwari, A.K.; Suresh Babu, K.; Srinivas, P.V.; Ali, A.Z.; Madhusudana Rao, J.

Bioorg. Med. Chem. Lett.

18

1659-1662

681559

16802696

Inhibition of alpha-glucosidase and alpha-amylase by flavonoids

2006

Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T.

J. Nutr. Sci. Vitaminol.

52

149-153

682159

16488884

Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I

2006

Das, B.B.; Sen, N.; Roy, A.; Dasgupta, S.B.; Ganguly, A.; Mohanta, B.C.; Dinda, B.; Majumder, H.K.

Nucleic Acids Res.

34

1121-1132

684844

17379189

12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells

2007

Weisinger, G.; Limor, R.; Marcus-Perlman, Y.; Knoll, E.; Kohen, F.; Schinder, V.; Firer, M.; Stern, N.

Biochem. Biophys. Res. Commun.

356

554-560

686330

17522976

12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway

2008

Chen, F.L.; Wang, X.Z.; Li, J.Y.; Yu, J.P.; Huang, C.Y.; Chen, Z.X.

Digest. Dis. Sci.

53

181-187

687143

17443494

Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism

2007

Endsley, M.P.; Aggarwal, N.; Isbell, M.A.; Wheelock, C.E.; Hammock, B.D.; Falck, J.R.; Campbell, W.B.; Nithipatikom, K.

Int. J. Cancer

121

984-991

688221

17164225

Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways

2007

Schweiger, D.; Fuerstenberger, G.; Krieg, P.

J. Lipid Res.

48

553-564

688759

17400255

Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells

2007

Higuchi, Y.; Tanii, H.; Koriyama, Y.; Mizukami, Y.; Yoshimoto, T.

Life Sci.

80

1856-1864

689106

17693955

Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase

2007

Gao, H.; Nishida, J.; Saito, S.; Kawabata, J.

Molecules

12

86-97

690148

18403085

Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets

2008

Lim, K.M.; Kim, J.S.; Bae, O.N.; Noh, J.Y.; Chung, S.M.; Chung, K.Y.; Chung, J.H.

Toxicology

247

154-160

691217

18258440

Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects

2008

Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S.

Bioorg. Med. Chem.

16

3969-3975

693392

18569333

Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria

2008

Ahmad, I.; Fatima, I.

J. Enzyme Inhib. Med. Chem.

23

313-316

697274

19010313

Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action?

2009

Brunskole, M.; Zorko, K.; Kerbler, V.; Martens, S.; Stojan, J.; Gobec, S.; Lanisnik Rizner, T.

Chem. Biol. Interact.

178

259-267

699839

18620056

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid dehydrogenase (17beta-HSD3)

2008

Lota, R.K.; Olusanjo, M.S.; Dhanani, S.; Owen, C.P.; Ahmed, S.

J. Steroid Biochem. Mol. Biol.

111

128-137

700186

18835421

Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1

2009

Brozic, P.; Kocbek, P.; Sova, M.; Kristl, J.; Martens, S.; Adamski, J.; Gobec, S.; Lanisnik Rizner, T.

Mol. Cell. Endocrinol.

301

229-234

702681

20097567

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase

2010

Arioka, S.; Sakagami, M.; Uematsu, R.; Yamaguchi, H.; Togame, H.; Takemoto, H.; Hinou, H.; Nishimura, S.

Bioorg. Med. Chem.

18

1633-1640

703078

18174253

Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency

2008

Piao, Y.S.; Du, Y.C.; Oshima, H.; Jin, J.C.; Nomura, M.; Yoshimoto, T.; Oshima, M.

Carcinogenesis

29

440-447

705256

19737346

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

2009

Pallast, S.; Arai, K.; Wang, X.; Lo, E.H.; van Leyen, K.

J. Neurochem.

111

882-889

705902

18680775

Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes

2008

Prasad, V.V.; Nithipatikom, K.; Harder, D.R.

Neurochem. Int.

53

220-229

706115

10724177

Purification and characterization of UDP-glucuronate: baicalein 7-O-glucuronosyltransferase from Scutellaria baicalensis Georgi. cell suspension cultures

2000

Nagashima, S.; Hirotani, M.; Yoshikawa, T.

Phytochemistry

53

533-538

706877

19752603

15-lipoxygenase-1 in colorectal cancer: a review

2009

Bhattacharya, S.; Mathew, G.; Jayne, D.G.; Pelengaris, S.; Khan, M.

Tumour Biol.

30

185-199

712081

-

CHS and UBGAT expression and baicalin accumulation in the roots of Scutellaria baicalensis Georgi during cultivation seasons

2006

Wang, W.; Chen, J.-k.; Zhou, T.-s.

Fudan Xuebao Ziran Kexueban

45

674-678

712230

20847417

Oren-gedoku-to and its constituents with therapeutic potential in Alzheimers disease inhibit indoleamine 2, 3-dioxygenase activity in vitro

2010

Yu, C.J.; Zheng, M.F.; Kuang, C.X.; Huang, W.D.; Yang, Q.

J. Alzheimers Dis.

22

257-266

712802

19911203

Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: A steered molecular dynamics study

2010

Mascayano, C.; Núñez, G.; Acevedo, W.; Rezende, M.

J. Mol. Model.

16

1039-1045

718420

20828797

A series of natural flavonoids as thrombin inhibitors: structure-activity relationships

2010

Liu, L.; Ma, H.; Yang, N.; Tang, Y.; Guo, J.; Tao, W.; Duan, J.

Thromb. Res.

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727634

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Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kappaB

2013

Dilly, A.K.; Ekambaram, P.; Guo, Y.; Cai, Y.; Tucker, S.C.; Fridman, R.; Kandouz, M.; Honn, K.V.

Int. J. Cancer

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1784-1791

728826

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12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity

2013

Yeung, J.; Apopa, P.L.; Vesci, J.; Stolla, M.; Rai, G.; Simeonov, A.; Jadhav, A.; Fernandez-Perez, P.; Maloney, D.J.; Boutaud, O.; Holman, T.R.; Holinstat, M.

Thromb. Haemost.

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569-581

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Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase

2014

Wei, Y.; Peng, A.Y.; Wang, B.; Ma, L.; Peng, G.; Du, Y.; Tang, J.

Eur. J. Med. Chem.

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751-758

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Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli

2015

Sabbagh, G.; Berakdar, N.

J. Mol. Graph. Model.

61

214-223

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Discovery of small molecule inhibitors of xyloglucan endotransglucosylase (XET) activity by high-throughput screening

2015

Chormova, D.; Franková, L.; Defries, A.; Cutler, S.; Fry, S.

Phytochemistry

117

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Identification of novel polyphenolic inhibitors of shikimate dehydrogenase (AroE)

2014

Peek, J.; Shi, T.; Christendat, D.

J. Biomol. Screen.

19

1090-1098

742456

23578768

12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival

2013

Weisinger, G.; Grafi-Cohen, M.; Hirsh, M.; Knoll, E.; Sharon, O.; Many, A.; Limor, R.; Stern, N.

Exp. Cell Res.

319

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742613

26216303

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

2015

Ivanov, I.; Kuhn, H.; Heydeck, D.

Gene

573

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Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2

2018

Weng, Z.M.; Ge, G.B.; Dou, T.Y.; Wang, P.; Liu, P.K.; Tian, X.H.; Qiao, N.; Yu, Y.; Zou, L.W.; Zhou, Q.; Zhang, W.D.; Hou, J.

Bioorg. Chem.

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Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition kinetics and interaction mechanism merged with simulations

2019

Liu, Z.B.; Sun, C.P.; Xu, J.X.; Morisseau, C.; Hammock, B.D.; Qiu, F.

Int. J. Biol. Macromol.

133

1187-1193

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Molecular interactions of flavonoids to pepsin Insights from spectroscopic and molecular docking studies

2015

Zeng, H.J.; Yang, R.; Liang, H.; Qu, L.B.

Spectrochim. Acta A. Mol. Biomol. Spectrosc.

151

576-590

756762

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Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase

2020

Seo, D.H.; Yoo, S.H.; Choi, S.J.; Kim, Y.R.; Park, C.S.

Food Sci. Biotechnol.

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The identification and functional characterization of three liverwort class I O-methyltransferases

2019

Liu, H.; Xu, R.X.; Zhang, X.S.; Zhu, T.T.; Lou, H.X.; Cheng, A.X.

Phytochemistry

159

190-198

758068

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Isolation and functional characterization of two caffeoyl coenzyme A 3-O-methyltransferases from the fern species Polypodiodes amoena

2019

Zhang, X.S.; Ni, R.; Wang, P.Y.; Zhu, T.T.; Sun, C.J.; Lou, H.X.; Cheng, A.X.

Plant Physiol. Biochem.

136

169-177

758175

30452462

Enzymatic synthesis of ?-flavone glucoside via regioselective transglucosylation by amylosucrase from Deinococcus geothermalis

2018

Jang, S.W.; Cho, C.H.; Jung, Y.S.; Rha, C.; Nam, T.G.; Kim, D.O.; Lee, Y.G.; Baek, N.I.; Park, C.S.; Lee, B.H.; Lee, S.Y.; Shin, H.S.; Seo, D.H.

PLoS ONE

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759341

29894785

Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase

2018

Wen, Q.H.; Wang, L.H.; Zeng, X.A.; Niu, D.B.; Wang, M.S.

Int. J. Biol. Macromol.

118

588-598

759388

30821967

Identification and characterization of two new 1-O-acyl-glucose-ester forming glucosyltransferases from Erigeron breviscapus

2019

Yang, Y.; Liu, M.; Zhang, W.; Cao, Y.; Li, C.; Wang, W.

J. Agric. Food Chem.

67

2848-2855

759908

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H2O2 improves quality of radix scutellariae through anti-oxidant effect

2016

Qi, S.; Cao, W.; Hua, J.; Zhang, A.; Meng, X.

Pharmacogn. Mag.

12

84-90

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Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids

2014

Pandey, R.; Gurung, R.; Parajuli, P.; Koirala, N.; Tuoi, L.; Sohng, J.

Carbohydr. Res.

393

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Antimicrobial mechanism of epigallocatechin gallate and gallocatechin gallate they target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway

2017

Hui, X.; Hua, S.H.; Wu, Q.Q.; Li, H.; Gao, W.Y.

Arch. Biochem. Biophys.

622

1-8

764112

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Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

2017

Maucher, I.V.; Ruehl, M.; Kretschmer, S.B.; Hofmann, B.; Kuehn, B.; Fettel, J.; Vogel, A.; Fluegel, K.T.; Manolikakes, G.; Hellmuth, N.; Haefner, A.K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.

Biochem. Pharmacol.

125

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Characterization of the Trypanosoma brucei pteridine reductase active-site using computational docking and virtual screening techniques

2020

Shamshad, H.; Hafiz, A.; Althagafi, I.I.; Saeed, M.; Mirza, A.Z.

Curr. Comput. aided Drug Des.

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12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage An in vivo study

2022

Choudhary, R.; Kumar, M.; Katyal, A.

Redox Biol.

49

102228

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