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Ligand 1-acyl-2-arachidonoyl-glycerophosphocholine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.23

arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine = CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine

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-

2.3.1.23

arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine

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-

2.3.1.23

2 entries

Substrate in Enzyme-catalyzed Reactions (6 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.147

1-Alkenyl-2-lysoglycerophospholipid + 1-acyl-2-arachidonoyl-glycerophosphocholine = 1-Alkenyl-2-arachidonyl-glycerophospholipid + 1-acyl-2-lyso-glycerophosphocholine

16272

-

2.3.1.147

1-Alkyl-2-lysoglycerophospholipid + 1-acyl-2-arachidonoyl-glycerophosphocholine = ?

16272

-

2.3.1.147

1-alkyl-2-lyso-glyceryl-3-phosphorylcholine + 1-acyl-2-arachidonoyl-glyceryl-3-phosphorylcholine = 1-alkyl-2-arachidonoylglycerophosphocholine + 1-acyl-2-lyso-glycerophosphocholine

16274

-

2.3.1.147

3 entries

2.3.1.148

1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine = 1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

16278

-

3.1.1.4

1-acyl-2-arachidonoyl-glycerophosphocholine + H2O = 1-acyl-glycerophosphocholine + arachidonic acid

133895

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3.1.1.4

1-acyl-2-arachidonoyl-sn-glycerophosphocholine + H2O = 1-acyl-sn-glycerophosphocholine + arachidonic acid

133894

-

3.1.1.4

2 entries

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.148

1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine = 1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

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-

2.3.1.23

arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine = CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine

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-

2.3.1.23

arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine

, 486634, 486624, 486650, 486627, 486632

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2.3.1.23

2 entries

3.1.1.4

phosphatidylcholine + arachidonic acid = 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine + carboxylic acid

133888

-

Enzyme Kinetic Parameters

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

16272

7944398

Coenzyme A-independent transacylation in amnion-derived (WISH) cells

1994

Toyoshima, K.; Narahara, H.; Frenkel, R.A.; Johnston, J.M.

Arch. Biochem. Biophys.

314

224-228

16274

1900206

Characterization of CoA-independent transacylase activity in U937 cells

1991

Winkler, J.D.; Sung, C.M.; Bennett, C.F.; Chilton, F.H.

Biochim. Biophys. Acta

1081

339-346

16278

1641397

The role of transacylases in the metabolism of arachidonate and platelet activating factor

1992

Snyder, F.; Lee, T.C.; Blank, M.L.

Prog. Lipid Res.

31

65-86

133888

8328965

Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca2+-dependent membrane association

1993

Rehfeldt, W.; Resch, K.; Goppelt-Struebe, M.

Biochem. J.

293

255-261

133894

1910288

Localization and characterization of phospholipase A2 in mouse mammary gland-derived cells

1991

Steiner, M.

Arch. Biochem. Biophys.

286

293-299

133895

1903717

Purification and characterization of human platelet phospholipase A2 which preferentially hydrolyzes an arachidonoyl residue

1991

Takayama, K.; Kudo, I.; Kim, D.K.; Nagata, K.; Nozawa, Y.; Inoue, K.

FEBS Lett.

282

326-330

486624

3707126

Purification and properties of acyl-CoA:1-acyl-sn-glycero-3-phosphocholine-O-acyltransferase from bovine brain microsomes

1986

Deka, N.; Sun, G.Y.; MacQuarrie, R.

Arch. Biochem. Biophys.

246

554-563

486627

7306562

A comparison of lysophosphatidylcholine acyltransferase activities in neuronal nuclei and microsomes isolated from immature rabbit cerebral cortex

1981

Baker, R.R.; Chang, H.Y.

Biochim. Biophys. Acta

666

223-229

486632

7407680

Relative suitability of 1-palmitoyl and 1-stearoyl homologues of 1-acyl-sn-glycerylphosphorylcholine and different acyl donors for phosphatidylcholine synthesis via acyl-CoA:1-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat lung microsomes

1980

Holub, B.J.; Piekarski, J.; Possmayer, F.

Can. J. Biochem.

58

434-439

486634

1054842

Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes

1975

Yamashita, S.; Nakaya, N.; Miki, Y.; Numa, S.

Proc. Natl. Acad. Sci. USA

72

600-603

486650

9126285

Acyl-CoA:lysophosphatidylcholine acyltransferase activity in bovine retina rod outer segments

1997

Castagnet, P.I.; Giusto, N.M.

Arch. Biochem. Biophys.

340

124-134

Links to other databases for 1-acyl-2-arachidonoyl-glycerophosphocholine

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Show Links (1 entry)