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Ligand benzyloxycarbonyl-Gly-Pro-p-nitroanilide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.21.26

benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O = benzyloxycarbonyl-Gly-Pro + p-nitroaniline

652752, 649523, 653873

-

3.4.21.26

benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O = ?

81326, 81347, 81353, 81350, 81358

-

3.4.21.26

2 entries

3.4.21.27

benzyloxycarbonyl-Gly-Pro-p-nitroanilide = benzyloxycarbonyl-Gly-Pro + p-nitroaniline

36541

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.4.21.26

3.8

-

-

653873

3.4.21.26

16.9

-

pH 7.5, 85°C

652752

3.4.21.26

2 entries

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.21.26

0.16

-

pH 7.5, 85°C

652752

3.4.21.26

0.4

-

-

653873

3.4.21.26

2 entries

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

36541

1645530

Purification and characterization of human brain prolyl endopeptidase

1991

Kalwant, S.; Porter, A.G.

Biochem. J.

276

237-244

81326

7028730

Post-proline cleaving enzyme from lamb brain

1981

Yoshimoto, T.; Simmons, W.H.; Kita, T.; Tsuru, D.

J. Biochem.

90

325-334

81347

9171407

Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus

1997

Harwood, V.J.; Denson, J.D.; Robinson-Bidle, K.A.; Schreier, H.J.

J. Bacteriol.

179

3613-3618

81350

1569074

Characterization of a prolyl endopeptidase from Flavobacterium meningosepticum. Complete sequence and localization of the active-site serine

1992

Chevallier, S.; Goeltz, P.; Thibault, P.; Banville, D.; Gagnon, J.

J. Biol. Chem.

267

8192-8199

81353

8148011

Proteolysis in heterocyst-forming cyanobacteria: Characterization of a further enzyme with trypsin-like specificity, and of prolyl endopeptidase from Anabaena variabilis

1994

Strohmeier, U.; Gerdes, C.; Lockau, W.

Z. Naturforsch. C

49

70-78

81358

9750174

Prolyl endopeptidase from Sphingomonas capsulata: isolation and characterization of the enzyme and nucleotide sequence of the gene

1998

Kabashima, T.; Fujii, M.; Meng, Y.; Ito, K.; Yoshimoto, T.

Arch. Biochem. Biophys.

358

141-148

649523

11534759

Prolyl endopeptidase inhibitors from green tea

2001

Kim, J.H.; Kim, S.I.; Song, K.S.

Arch. Pharm. Res.

24

292-296

652752

14521416

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides

2003

Wallen, E.A.; Christiaans, J.A.; Jarho, E.M.; Forsberg, M.M.; Venalainen, J.I.; Mannisto, P.T.; Gynther, J.

J. Med. Chem.

46

4543-4551

653873

-

Proline-specific endopeptidases

2003

Besedin, D.V.; Rudenskaya, G.N.

Russ. J. Bioorg. Chem.

29

1-17

Links to other databases for benzyloxycarbonyl-Gly-Pro-p-nitroanilide

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Show Links (1 entry)

ChEBI

PubChem

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