Ligand 1-palmitoyl-sn-glycerol

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Basic Ligand Information

Molecular Structure
Picture of 1-palmitoyl-sn-glycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H38O4
1-palmitoyl-sn-glycerol
QHZLMUACJMDIAE-UHFFFAOYSA-N
Synonyms:
1-monopalmitin, 1-monopalmitoylglycerol, 1-O-Hexadecylglycerol, 1-palmitin, 1-palmitoylglycerol, DL-alpha-palmitin, Glycerol monopalmitate, glycerol palmitate, monopalmitin, monopalmitoylglycerol, palmitin, palmitoyl glycerol, rac-1-monopalmitoylglycerol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-O-hexadecylglycerol + tetrahydrobiopterin + O2 = 1-O-(1-hydroxy-hexadecyl)-sn-glycerol + dihydrobiopterin + H2O
show the reaction diagram
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palmitoyl-CoA + 1-monopalmitin = CoA + ?
show the reaction diagram
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glycerol monopalmitate + H2O = glycerol + palmitic acid
show the reaction diagram
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glycerol palmitate + H2O = glycerol + palmitate
show the reaction diagram
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palmitoyl glycerol = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dipalmitoylglycerol + sterol = monopalmitoylglycerol + steryl palmitate
show the reaction diagram
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glycerol + palmitic acid = monopalmitin + H2O
show the reaction diagram
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dipalmitin + H2O = monopalmitoylglycerol + palmitate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
44% inhibition of the membraneous enzyme at 0.1 mM, 38% inhibition of the cytosolic enzyme at 0.1 mM
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IC50: 0.0080, complete inhibition is possible
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Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.66
-
-
0.01639
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IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.008
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IC50: 0.0080 mM, complete inhibition is possible

References & Links

Links to other databases for 1-palmitoyl-sn-glycerol

ChEBI
PubChem
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PubChem