Ligand thrombin

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Basic Ligand Information

Molecular Formula
BRENDA Name
InChIKey
thrombin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thrombin + H2O = ?
show the reaction diagram
-
thrombin + H2O = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thrombinogen + H2O = thrombin + ?
show the reaction diagram
-
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thrombin + H2O = ?
show the reaction diagram
-
thrombin + H2O = ?
show the reaction diagram
-
thrombin + H2O = ?
show the reaction diagram
-
thrombin + H2O = ?
show the reaction diagram
-
thrombin + H2O = ?
show the reaction diagram
-
vitronectin + thrombin + antithrombin = vitronectin-thrombin-antithrombin
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thrombinogen + H2O = thrombin + ?
show the reaction diagram
-
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-
prothrombin + H2O = thrombin + thrombin propeptide
show the reaction diagram
-
-
prothrombin + H2O = thrombin + ?
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.3 units/ml, approx. 5fold activation in endothelial cells in the presence of low-density lipoprotein
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activation of enzyme in intact cells, blocked by pertussis toxin
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stimulation of the lung epithelial cell line A-549 by thrombin leads to transient increase of SPHK1 activity and elevation of intracellular sphingosine 1-phosphate, abrogation of this stimulation by SPHK1-specific siRNA, pharmacological inhibition, or expression of a dominant-negative SPHK1 mutant blocks the response to thrombin. PAR-1 or thrombin-induced cytokine production and adhesion factor expression of human umbilical vein endothelial cells is also dependent on SPHK1
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stimulates endothelial isozyme activity in endothelium, and increases EC MLCK interaction with macrophage migration inhibition factor MIF
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transiently increases PTEN lipid phosphatase activity by about 2.5fold within 1 min, which remains elevated for 5 min
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treatment of cells results in enhancement of collagen production and enzyme activity and expression, accompanied by raise in expression of focal adhesion kinase pp125 and mitogen-activated protein kinases
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dependent on, molecular mechanisms underlying thrombin-mediated MMP-2 activation, overview. Interaction of MMP-2 with exosites 1 and 2 of thrombin is crucial for thrombin- mediated MMP-2 degradation, and inhibition of this interaction by heparan sulfate or hirudin fragment results in a decrease in MMP-2 degradation, interaction between exosite 1 and hemopexin-like domain of MMP-2
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stimulates Rac1 as cardiovascular stimulus
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induces platelet phosphatidylserine exposure, inhibited by c7E3 or SR121566
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulation results in an increase in the apparent KM of DGKtheta at low concentrations of substrate dioleoylglycerol. Increasing the bulk concentration of dioleoylglycerol returns the apparent KM to the basal value
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proteolytic cleavage only of the heat-denatured enzyme, not of the native enzyme
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activates Rho/Rho kinase to inactivate PP-1M
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thrombin transiently inhibits adenylyl cyclase 6
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enzyme is highly susceptible too proteolytic cleavage
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Enzyme Kinetic Parameters

References & Links

Links to other databases for thrombin