Ligand sulfanilamide

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Basic Ligand Information

Molecular Structure
Picture of sulfanilamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H8N2O2S
sulfanilamide
FDDDEECHVMSUSB-UHFFFAOYSA-N
Synonyms:
4-amino-1-benzenesulfonamine, 4-amino-benzenesulfonamide, 4-aminobenzene-1-sulfonamide, 4-aminobenzenesulfanilamide, 4-Aminobenzenesulfonamide, ambeside, p-aminobenzene sulfamide, p-aminobenzenesulfonamide, sulphanilamide

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + sulfanilamide = CoA + ?
show the reaction diagram
-
glutathione + sulfanilamide = ?
show the reaction diagram
-
thiamine + sulfanilamide = ?
show the reaction diagram
-
sulfanilamide + H2O = sulfanilate + NH3
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-(4'-sulfonaminophenylazo-)2-naphthol + NAD(P)H = 4-amino-1-benzenesulfonamine + NAD(P)+ + 1-amino-2-hydroxynaphthalene
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reaction rate increased by sulfadiazine sodium salt, sulfamethoxazole, sulfamethazole, sulfanilamide, sulfathiazole sodium salt in presence of both substrates
stimulates
-

Inhibitor in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-
competitive inhibition
-
use in yeast protein fragment complementation assay system to prevent endogenous dihydrofolate reductase activity
-

3D Structure of Enzyme-Ligand-Complex (PDB) (41 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.08
-
in absence of 4-aminobenzoate

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
77
-
-

Ki Value (55 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.037
-
25°C, pH 8.5
0.0267
-
-
0.0357
-
at pH 6.0 and 22°C
0.267
-
at 25°C

IC50 Value (7 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.119
-
25°C, pH 8.5
0.23
-
-
0.848
-
at pH 6.0 and 22°C
0.23
-
at 25°C

References & Links

Links to other databases for sulfanilamide

ChEBI
PubChem
ChEBI
PubChem