Ligand all-trans-retinal

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Basic Ligand Information

Molecular Structure
Picture of all-trans-retinal (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H28O
all-trans-retinal
NCYCYZXNIZJOKI-OVSJKPMPSA-N
Synonyms:
all-trans-retinaldehyde, all-trans retinal, all-trans retinaldehyde, retinal, retinaldehyde, vitamin A aldehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
all-trans retinal + NADPH + H+ = all-trans retinol + NADP+
show the reaction diagram
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all-trans-retinal + NAD+ + H2O = all-trans-retinoic acid + NADH + H+
show the reaction diagram
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retinal + NAD+ + H2O = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
all-trans-retinol + NAD+ = all-trans-retinal + NADH
show the reaction diagram
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all-trans-8'-apocarotenol + O2 = all-trans-retinal + (2E,4E,6E)-8-hydroxy-2,6-dimethylocta-2,4,6-trienal
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (62 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
all-trans-retinal + NADPH = ? + NADP+
show the reaction diagram
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all-trans-retinal + NADPH + H+ = ?
show the reaction diagram
-
retinal + NADPH = retinol + NADP+
show the reaction diagram
-
all-trans-retinal + NADPH + H+ = all-tans-retinol + NADP+
show the reaction diagram
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all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
show the reaction diagram
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retinal + NAD+ + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (59 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
all-trans-retinol + NADP+ = all-trans-retinal + NADPH
show the reaction diagram
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all-trans-retinol + NADP+ = all-trans-retinal + NADPH
show the reaction diagram
-
-
all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+
show the reaction diagram
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beta,beta-carotene + O2 = all-trans retinal + ?
show the reaction diagram
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beta-apo-10'-carotenal + O2 = retinal + 3-methylbut-2-enal
show the reaction diagram
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beta-apo-10'-carotenal + O2 = retinal + ?
show the reaction diagram
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all-trans-retinol + NAD(P)H = NAD(P)+ + H2O + all-trans-retinaldehyde
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
retinal (0.007 and 0.014 mM) increases CAT activity after 24 h of treatment
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition
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IC50: 0.45 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (35 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.028
-
at pH 6.5 and 60°C
0.05
-
pH 7.4, 25°C
0.0085
-
at pH 7.4 and 37°C
0.08
-
pH 7.4
0.004
-
pH 7.4, temperature not specified in the publication
0.005
-
with NAD+ as cosubstrate, at pH 7.0 and 37°C

KM Value (89 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.024
-
pH 7.4, 25°C
0.0089
-
at pH 7.4 and 37°C
0.009
-
pH 7.4
0.02
-
-
0.008
-
-
0.08
-
pH 7.4, 37°C
0.00035
-
pH 7.4, temperature not specified in the publication
0.0093
-
at pH 8.0 and 25°C
0.007
-
with NAD+ as cosubstrate, at pH 7.0 and 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.45
-
IC50: 0.45 mM

References & Links

Links to other databases for all-trans-retinal

ChEBI
PubChem
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PubChem