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Ligand methemoglobin

Basic Ligand Information

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.6.2.2

methemoglobin + NADH = hemoglobin + NAD+

657460

-

1.6.2.2

NADH + methemoglobin = NAD+ + hemoglobin

713204

-

1.6.2.2

2 entries

3.4.22.47

methemoglobin + H2O = ?

696529

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.18

methemoglobin + electron donor + O2 = ?

438244, 438243

-

1.6.2.2

methemoglobin + NADH = hemoglobin + NAD+

657460

-

1.6.2.2

NADH + methemoglobin = NAD+ + hemoglobin

713204

-

1.6.2.2

2 entries

3.4.22.47

methemoglobin + H2O = ?

677827, 696529

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.1.90

-

695615

-

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

438243

18477

Solubilization and partial purification of heme oxygenase from rat liver

1977

Maines, M.D.; Ibrahim, N.G.; Kappas, A.

J. Biol. Chem.

252

5900-5903

438244

672640

Assay of microsomal heme oxygenase in liver and spleen

1978

Schacter, B.A.

Methods Enzymol.

52

367-372

657460

15502298

Structure of human erythrocyte NADH-cytochrome b5 reductase

2004

Bando, S.; Takano, T.; Yubisui, T.; Shirabe, K.; Takeshita, M.; Nakagawa, A.

Acta Crystallogr. Sect. D

60

1929-1934

677827

17577572

Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhemoglobin

2007

Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.

Arch. Biochem. Biophys.

465

44-49

695615

3896125

Vitamin K-dependent carboxylase

1985

Suttie, J.W.

Annu. Rev. Biochem.

54

459-477

696529

18713010

Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis

2008

Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.

Biol. Chem.

389

1235-1238

713204

-

Estimation of cytochrome b5 reductase activity in red blood cells of Rattus norvegicus after the treatment of trichloroacetic acid

2009

Siddique, Y.; Ara, G.; Gupta, J.; Beg, T.; Afzal, M.

Pharmacologyonline

3

986-990

Links to other databases for methemoglobin

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Show Links (1 entry)