Ligand ergothioneine
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Basic Ligand Information
Molecular Structure

C10H17N3O2S
ergothioneine
FGHUBPMCAWNMKL-QMMMGPOBSA-N
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O
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S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + ammonia + acceptor
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Product in Enzyme-catalyzed Reactions (2 results)
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2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O
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S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + ammonia + acceptor
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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the enzyme activity is reduced by 10% in the presence of ergothioneine
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a natural trimethyl-2-thiohistidine, 50% inhibition at 0.297 mM. Reversible inhibition mechanism
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a natural trimethyl-2-thiohistidine, reversible inhibition mechanism
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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Biochemical and biophysical characterization of a mycoredoxin protein glutaredoxin A1 from Corynebacterium pseudotuberculosis
2018
Eberle, R.J.; Kawai, L.A.; de Moraes, F.R.; Tasic, L.; Arni, R.K.; Coronado, M.A.
Int. J. Biol. Macromol.
107
1999-2007
Probing the interactions of sulfur-containing histidine compounds with human gamma-glutamyl transpeptidase
2019
Milito, A.; Brancaccio, M.; Lisurek, M.; Masullo, M.; Palumbo, A.; Castellano, I.
Mar. Drugs
17
650
Links to other databases for ergothioneine