Ligand D-Tyr-Val-2-hydroxyglycine

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Basic Ligand Information

Molecular Structure

C₁₆H₂₃N₃O₆

D-Tyr-Val-2-hydroxyglycine

IGAXRFYCFQAJTJ-XUJVJEKNSA-N

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Roles as Enzyme Ligand

Product in Enzyme-catalyzed Reactions (1 result)

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1.14.17.3

D-Tyr-Val-Gly + ascorbate + O2 = D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O

0, 438562, 438589, 438563, 438564, 438579, 438570, 438565, 438590, 438572, 438586

Enzyme Kinetic Parameters

References & Links

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Show Reference (10 entries)

438562

2994573

Further characterization of the peptidyl alpha-amidating enzyme in rat anterior pituitary secretory granules

1985

Glembotski, C.C.

Arch. Biochem. Biophys.

241

673-683

438563

3691506

Enzyme-catalysed peptide amidation. Isolation of a stable intermediate formed by reaction of the amidating enzyme with an imino acid

1987

Bradbury, A.F.; Smyth, D.G.

Eur. J. Biochem.

169

579-584

438564

7099265

Mechanism of C-terminal amide formation by pituitary enzymes

1982

Bradbury, A.F.; Finnie, M.D.A.; Smyth, D.G.

Nature

298

686-689

438565

3291863

Peptidyl-glycine alpha-amidating mono-oxygenase activity towards a gonadotropin-releasing-hormone C-terminal peptide substrate, in subcellular fractions of sheep brain and pituitary

1988

Gale, J.S.; McIntosh, J.E.A.; McIntosh, R.P.

Biochem. J.

251

251-259

438570

3944110

Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary

1986

Murthy, A.S.N.; Mains, R.E.; Eipper, B.A.

J. Biol. Chem.

261

1815-1822

438572

6725255

Characterization of a peptide alpha-amidation activity from rat anterior pituitary

1984

Glembotski, C.C.; Eipper, B.A.; Mains, R.E.

J. Biol. Chem.

259

6385-6392

438579

2732216

Purification and characterization of a peptide C-terminal alpha-amidating enzyme from porcine atrium

1989

Kojima, M.; Mizuno, K.; Kangawa, K.; Matsuo, H.

J. Biochem.

105

440-443

438586

8632187

Identification, purification, and characterization of the molecular forms of Aplysia californica peptidylglycine alpha-amidating enzyme

1996

Boudreault, A.; Castellucci, V.F.; Chretien, M.; Lazure, C.

J. Neurochem.

2596-2605

438589

7540562

The irreversible inactivation of two copper-dependent monooxygenases by sulfite: peptidylglycine alpha-amidating enzyme and dopamine beta-monooxygenase

1995

Merkler, D.J.; Kulathila, R.; Francisco, W.A.; Ash, D.E.; Bell, J.

FEBS Lett.

366

165-169

438590

Kinetic isotope effects of peptidylglycine a-hydroxylating mono-oxygenase reaction

1998

Takahashi, K.; Onami, T.; Noguchi, M.

Biochem. J.

336

131-137