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Ligand L-m-Tyr Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C9 H1 1 NO3
L-m-Tyr
JZKXXXDKRQWDET-QMMMGPOBSA-N
(2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid, 3-hydroxy-L-phenylalanine, 3-L-tyrosine, L-m-tyrosine, m-hydroxyphenylalanine, m-Tyr
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-phenylalanine + tetrahydrobiopterin + O2 = 3-hydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin
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Substrate in Enzyme-catalyzed Reactions (8 results)
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dimethylallyl diphosphate + L-m-tyrosine = diphosphate + 4-(3-methylbut-2-enyl)-L-m-tyrosine + 6-(3-methylbut-2-enyl)-L-m-tyrosine
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L-m-Tyr + pyridoxal phosphate = pyridoxamine phosphate + keto acid
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(2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid = (2E)-3-(3-hydroxyphenyl)prop-2-enoic acid + NH3
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ATP + 3-L-tyrosine + tRNAPhe = AMP + diphosphate + 3-L--tyrosyl-tRNAPhe
ATP + 3-L-tyrosine + tRNAPhe = AMP + diphosphate + 3-L--tyrosyl-tRNAPhe
ATP + 3-L-tyrosine + tRNAPhe = AMP + diphosphate + 3-L-tyrosyl-tRNAPhe
ATP + 3-L-tyrosine + tRNAPhe = AMP + diphosphate + 3-L-tyrosyl-tRNAPhe
Product in Enzyme-catalyzed Reactions (4 results)
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L-phenylalanine + 6-methyltetrahydropterin + O2 = 3-hydroxy-L-phenylalanine + 4a-hydroxy-6-methyltetrahydropterin
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L-phenylalanine + tetrahydrobiopterin + O2 = 3-hydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin
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3-hydroxy-trans-cinnamate + NH3 = 3-hydroxy-L-phenylalanine
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3-hydroxy-trans-cinnamate + NH3 = 3-hydroxy-L-phenylalanine
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (4 results)
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0.0065
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pH 7.5, 37°C, recombinant enzyme
KM Value (5 results)
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0.9
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pH 7.5, 37°C, recombinant enzyme
1.15
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at pH 7.5 and 37°C
References & Links Literature References (12)
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Aromatic-L-amino-acid decarboxylase activity in mouse pancreatic islets
1986
Lindström, P.
Biochim. Biophys. Acta
884
276-281
-
Aromatic L-amino acid decarboxylase (guinea pig kidney)
1971
Lovenberg, W.
Methods Enzymol.
17B
652-656
Substrate specificity and other properties of dopa decarboxylase from guinea pig kidneys
1978
Srinivasan, K.; Awapara, J.
Biochim. Biophys. Acta
526
597-604
Aromatic-L-amino acid decarboxylase from pig kidney
1987
Voltattorni, C.B.; Giartosio, A.; Turano, C.
Methods Enzymol.
142
179-187
Transamination catalysed by tyrosine phenol-lyase from Citrobacter intermedius
1987
Demidkina, T.V.; Myagkikh, I.V.; Azhayev, A.V.
Eur. J. Biochem.
170
311-316
Elementary processes in the interaction of tyrosine phenol lyase with inhibitors and substrate
1978
Muro, T.; Nakatani, H.; Hiromi, K.; Kumagai, H.; Yamada, H.
J. Biochem.
84
633-640
Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. II. Kinetic properties
1972
Dopheide, T.A.A.; Crewther, P.; Davidson, B.E.
J. Biol. Chem.
247
4447-4452
Studies on 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli K12. 3. Structural studies
1976
Simpson, R.J.; Davidson, B.E.
Eur. J. Biochem.
70
509-516
Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity
2014
Lovelock, S.; Turner, N.
Bioorg. Med. Chem.
22
5555-5557
Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosines than tyrosine prenyltransferases
2015
Fan, A.; Xie, X.; Li, S.M.
Org. Biomol. Chem.
13
7551-7557
Molecular polygamy The promiscuity of L-phenylalanyl-tRNA-synthetase triggers misincorporation of meta- and ortho-tyrosine in monoclonal antibodies expressed by Chinese hamster ovary cells
2015
Popp, O.; Larraillet, V.; Kettenberger, H.; Gorr, I.H.; Hilger, M.; Lipsmeier, F.; Zeck, A.; Beaucamp, N.
Biotechnol. Bioeng.
112
1187-1199
Multiple quality control pathways limit non-protein amino acid use by yeast cytoplasmic phenylalanyl-tRNA synthetase
2016
Moghal, A.; Hwang, L.; Faull, K.; Ibba, M.
J. Biol. Chem.
291
15796-15805
Links to other databases for L-m-Tyr
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