Ligand 5,10-methenyltetrahydrofolate

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Basic Ligand Information

Molecular Structure
Picture of 5,10-methenyltetrahydrofolate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H21N7O6
5,10-methenyltetrahydrofolate
MEANFMOQMXYMCT-OLZOCXBDSA-O
Synonyms:
(6R,S)-methenyltetrahydrofolate, (R)-5,10-methylene-5,6,7,8-tetrahydrofolate, (R)-5,10-methylenetetrahydrofolate, 5,10-methenyl-tetrahydrofolate, 5,10-methenyl tetrahydrofolate, 5,10-methenyltetrahydrofolic acid, L-(+)-5,10-methenyltetrahydrofolate, L-(+-)-5,10-methenyltetrahydrofolate, L-5,10-methenyl-tetrahydrofolate, L-5,10-methenyltetrahydrofolate, methenyltetrahydrofolate, N5,N10-anhydroformyl-5,6,7,8tetrahydrofolic acid, N5,N10-anhydroformyl tetrahydrofolate, N5,N10-anhydroformyltetrahydrofolate, N5,N10-anhydroformyltetrahydrofolic acid, N5,N10-methenyltetrahydrofolate, N5,N10-methenyltetrahydrofolic acid


Show all pahtways known for Show all BRENDA pathways known for 5,10-methenyltetrahydrofolate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-5,10-methenyl-tetrahydrofolate + NADH = L-5,10-methylenetetrahydrofolate + NAD+
show the reaction diagram
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5,10-methenyltetrahydrofolate + FADH2 = 5,10-methylene tetrahydrofolate + FAD
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydrofolate = 5,10-methenyltetrahydrofolate + H2O
show the reaction diagram
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5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-5,10-methenyl-tetrahydrofolate + NADH = L-5,10-methylenetetrahydrofolate + NAD+
show the reaction diagram
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5,10-methenyltetrahydrofolate + reduced N,N-dimethylglycine = 5,10-methylene tetrahydrofolate + oxidized N,N-dimethylglycine
show the reaction diagram
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5,10-methenyltetrahydrofolate + FADH2 = 5,10-methylene tetrahydrofolate + FAD
show the reaction diagram
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N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide = N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Cofactor/Cosubstrate (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
dependent on
-
required
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (19 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.58
-
-

KM Value (53 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3
-
-

References & Links

Links to other databases for 5,10-methenyltetrahydrofolate

ChEBI
PubChem
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PubChem