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Ligand 4-hydroxypyridine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.209

pyridine-4-ol + NADP+ = 3H-pyridine-4-one + NADPH

286234

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Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.112

pyridine-4-aldehyde + NADH = pyridine-4-alcohol + NAD+

285760

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1.1.1.21

pyridine-4-aldehyde + NAD(P)H = 4-hydroxypyridine + NAD(P)+

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1.1.1.21

pyridine-4-aldehyde + NADPH + H+ = 4-hydroxypyridine + NADP+

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1.1.1.21

2 entries

1.1.1.64

pyridine-4-aldehyde + NADPH = pyridine-4-alcohol + NADP+

287226

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Inhibitor in Enzyme-catalyzed Reactions (8 results)

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Show Inhibitors (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.30

IC50: 2.3 mM

637997

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3.5.4.4

competitive inhibition

688040

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4.1.99.2

cleavage of Tyr

33447

6mls, 3D-view

4.1.99.2

cleavage of Tyr

33447

6mme, 3D-view

4.1.99.2

cleavage of Tyr

33447

6mo3, 3D-view

4.1.99.2

cleavage of Tyr

33447

6mpd, 3D-view

4.1.99.2

cleavage of Tyr

33447

6mqq, 3D-view

4.1.99.2

cleavage of Tyr

33447

6nv8, 3D-view

4.1.99.2

6 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (19 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (19 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.4.2.1

6b4q, 3D-view

4.1.99.2

6mls, 3D-view

4.1.99.2

6mme, 3D-view

4.1.99.2

6mo3, 3D-view

4.1.99.2

6mpd, 3D-view

4.1.99.2

6mqq, 3D-view

4.1.99.2

6nv8, 3D-view

4.1.99.2

6mls, 3D-view

4.1.99.2

6mme, 3D-view

4.1.99.2

6mo3, 3D-view

4.1.99.2

6mpd, 3D-view

4.1.99.2

6mqq, 3D-view

4.1.99.2

6nv8, 3D-view

4.1.99.2

6mls, 3D-view

4.1.99.2

6mme, 3D-view

4.1.99.2

6mo3, 3D-view

4.1.99.2

6mpd, 3D-view

4.1.99.2

6mqq, 3D-view

4.1.99.2

6nv8, 3D-view

4.1.99.2

18 entries

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.4.4

1.4

-

pH 7.5, 25°C

688040

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.4.2.30

2.3

-

IC50: 2.3 mM

637997

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

33447

7262088

Syntheses of L-tyrosine-related amino acids by tyrosine phenol-lyase of Citrobacter intermedius

1981

Nagasawa, T.; Utagawa, T.; Goto, J.; Kim, C.J.; Tani Y.; Kumagai, H.; Yamada, H.

Eur. J. Biochem.

117

33-40

285760

3527067

Isolation of multiple forms of indanol dehydrogenase associated with 17-beta-hydroxysteroid dehydrogenase activity from male rabbit

1986

Hara, A.; Kariya, K.; Nakamura, M.; Nakayama, T.; Saweda, H.

Arch. Biochem. Biophys.

249

225-236

286234

2691507

Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney

1989

Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.

J. Biochem.

106

633-638

287226

2983661

Guinea-pig liver testosterone 17beta-dehydrogenase (NADP+) and aldehyde reductase exhibit benzene dihydrodiol dehydrogenase activity

1985

Hara, A.; Hayashibara, M.; Nakayama, T.; Hasabe, K.; Usui, s.; Sawada, H.

Biochem. J.

225

177-181

637997

1530940

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase

1992

Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.

J. Biol. Chem.

267

1569-1575

688040

18343902

A study on the inhibition of adenosine deaminase

2008

Alunni, S.; Orru, M.; Ottavi, L.

J. Enzyme Inhib. Med. Chem.

23

182-189

Links to other databases for 4-hydroxypyridine

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Show Links (1 entry)

ChEBI

PubChem

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