Ligand 3-hydroxyglutaryl-CoA
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Basic Ligand Information
Molecular Structure
C26H42N7O20P3S
3-hydroxyglutaryl-CoA
IIYZSYKTQRIPRG-MJBWAWCGSA-N
Roles as Enzyme Ligand
Product in Enzyme-catalyzed Reactions (1 result)
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glutaconyl-CoA + 3-hydroxyglutarate = glutaconate + 3-hydroxyglutaryl-CoA
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Inhibitor in Enzyme-catalyzed Reactions (4 results)
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competitive; competitive inhibitor
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Ki: 0.05 mM, Ki of acetyl-CoA enolization: 0.095 mM
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Enzyme Kinetic Parameters
Ki Value (1 result)
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References & Links
Literature References (4)
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3-Hydroxy-3-methylglutaryl-CoA lyase: catalysis of acetyl coenzyme A enolization
1983
Kramer, P.R.; Miziorko, H.M.
Biochemistry
22
2353-2357
Substrate and inhibitor specificity of 3-hydroxy-3-methylglutaryl-CoA reductase determined with substrate-analogue CoA-thioesters and CoA-thioethers
1991
Hupperich, M.; Thomer, A.; Kratz, K.; Eggerer, H.
Biol. Chem. Hoppe-Seyler
372
857-863
Crystal structure of human HMG-CoA lyase: Insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria
2005
Fu, Z.; Runquist, J.A.; Forouhar, F.; Hussain, M.; Hunt, J.F.; Miziorko, H.M.; Kim, J.J.
J. Biol. Chem.
281
7526-7532
Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes
2010
Fu, Z.; Runquist, J.A.; Montgomery, C.; Miziorko, H.M.; Kim, J.J.
J. Biol. Chem.
285
26341-26349
Links to other databases for 3-hydroxyglutaryl-CoA
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