Ligand phytanate
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Basic Ligand Information
Molecular Structure
C20H40O2
phytanate
MRLXXQBBRNRWDA-LIEMUPCESA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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ATP + phytanate + CoA = ?
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Substrate in Enzyme-catalyzed Reactions (8 results)
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phytanic acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+ = ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
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phytanic acid + O2 + reduced ferredoxin [iron-sulfur] cluster + H+ = ?
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ATP + phytanate + CoA = ?
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ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA
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CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA
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GTP + phytanate + CoA = GMP + diphosphate + phytanoyl-CoA
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ITP + phytanate + CoA = IMP + diphosphate + phytanoyl-CoA
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UTP + phytanate + CoA = UMP + diphosphate + phytanoyl-CoA
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Activator in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
KM Value (2 results)
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0.054
-
at pH 7.4 and 25°C
References & Links
Literature References (7)
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Phytanoyl-CoA ligase activity in rat liver
1986
Muralidharan, F.N.; Muralidharan, V.B.
Biochem. Int.
13
123-130
Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes
1995
Pahan, K.; Singh, I.
J. Lipid Res.
36
986-997
Phytanic acid alpha-oxidation in rat liver mitochondria
1994
Pahan, K.; Gulati, S.; Singh, I.
Biochim. Biophys. Acta
1201
491-497
Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured skin fibroblasts
1993
Pahan, K.; Cofer, J.; Baliga, P.; Singh, I.
FEBS Lett.
322
101-104
Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis
2009
Johnston, J.B.; Kells, P.M.; Podust, L.M.; Ortiz de Montellano, P.R.
Proc. Natl. Acad. Sci. USA
106
20687-20692
A conserved amphipathic ligand binding region influences K-path-dependent activity of cytochrome C oxidase
2013
Hiser, C.; Buhrow, L.; Liu, J.; Kuhn, L.; Ferguson-Miller, S.
Biochemistry
52
1385-1396
Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism
2017
Vasilevskaya, A.V.; Yantsevich, A.V.; Sergeev, G.V.; Lemish, A.P.; Usanov, S.A.; Gilep, A.A.
J. Steroid Biochem. Mol. Biol.
169
202-209
Links to other databases for phytanate
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