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Ligand phytanate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.2.1.24

ATP + phytanate + CoA = ?

705, 703

-

Substrate in Enzyme-catalyzed Reactions (8 results)

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Show Substrate (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.14

phytanic acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+ = ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster

745645

-

1.14.15.14

phytanic acid + O2 + reduced ferredoxin [iron-sulfur] cluster + H+ = ?

735155

-

6.2.1.24

ATP + phytanate + CoA = ?

705, 703

-

6.2.1.24

ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA

703, 705, 702, 704

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6.2.1.24

CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA

702

-

6.2.1.24

GTP + phytanate + CoA = GMP + diphosphate + phytanoyl-CoA

702

-

6.2.1.24

ITP + phytanate + CoA = IMP + diphosphate + phytanoyl-CoA

702

-

6.2.1.24

UTP + phytanate + CoA = UMP + diphosphate + phytanoyl-CoA

702

-

1.14.15.14

2 entries

6.2.1.24

6 entries

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

7.1.1.9

-

741883

-

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.15.14

0.054

-

at pH 7.4 and 25°C

735155

6.2.1.24

0.0286

-

-

702

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

702

3753503

Phytanoyl-CoA ligase activity in rat liver

1986

Muralidharan, F.N.; Muralidharan, V.B.

Biochem. Int.

13

123-130

703

7544821

Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes

1995

Pahan, K.; Singh, I.

J. Lipid Res.

36

986-997

704

7803482

Phytanic acid alpha-oxidation in rat liver mitochondria

1994

Pahan, K.; Gulati, S.; Singh, I.

Biochim. Biophys. Acta

1201

491-497

705

8482375

Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured skin fibroblasts

1993

Pahan, K.; Cofer, J.; Baliga, P.; Singh, I.

FEBS Lett.

322

101-104

735155

19933331

Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis

2009

Johnston, J.B.; Kells, P.M.; Podust, L.M.; Ortiz de Montellano, P.R.

Proc. Natl. Acad. Sci. USA

106

20687-20692

741883

23351100

A conserved amphipathic ligand binding region influences K-path-dependent activity of cytochrome C oxidase

2013

Hiser, C.; Buhrow, L.; Liu, J.; Kuhn, L.; Ferguson-Miller, S.

Biochemistry

52

1385-1396

745645

27289046

Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism

2017

Vasilevskaya, A.V.; Yantsevich, A.V.; Sergeev, G.V.; Lemish, A.P.; Usanov, S.A.; Gilep, A.A.

J. Steroid Biochem. Mol. Biol.

169

202-209

Links to other databases for phytanate

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Show Links (1 entry)

ChEBI

PubChem

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