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Ligand N-acetyl-D-galactosamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.9

N-acetyl-D-galactosamine + O2 = ? + H2O2

389871, 389866, 389880, 389881, 389882

-

2.7.1.157

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

704525, 709300

-

2.7.1.162

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

758938, 760251

-

2.7.1.221

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-D-galactosamine 1-phosphate

743335

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.6.12

N-acetyl-D-galactosamine 4-sulfate units + H2O = N-acetyl-D-galactosamine units + sulfate

0

-

Substrate in Enzyme-catalyzed Reactions (18 results)

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Show Substrate (18 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.240

N-acetyl-D-galactosamine + NAD+ = N-acetyl-D-galactoseaminate + NADH

286366

-

1.1.3.29

N-acetyl-D-galactosamine + O2 = N-acetyl-D-galactosaminolactone + H2O2

762915, 389762

-

1.1.3.9

N-acetyl-D-galactosamine + O2 = ? + H2O2

389871, 389866, 389880, 389881, 389882

-

2.4.1.122

UDP-galactose + N-acetyl-D-galactosamine = UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine

638321, 638318

-

2.4.1.179

UDP-galactose + N-acetylgalactosamine = UDP + beta-D-galactosyl-1,3-N-acetylgalactosamine

638377

-

2.4.1.211

alpha-D-galactose 1-phosphate + N-acetyl-galactosamine = beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosmine + phosphate

703065, 758938

-

2.4.1.38

UDP-alpha-D-galactose + N-acetylgalactosamine = ?

489519

-

2.4.1.90

UDP-alpha-D-galactose + N-acetyl-D-galactosamine = ?

489519

-

2.4.3.1

CMP-N-acetylneuraminate + N-acetyl-D-galactosamine = ?

687452

-

2.5.1.56

N-acetyl-D-galactosamine + phosphoenolpyruvate + H2O = ?

637325

-

2.7.1.157

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

672583, 704525, 709300, 659129

-

2.7.1.162

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

737343, 758938, 760251, 702588, 703179

-

2.7.1.221

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-D-galactosamine 1-phosphate

743335

-

2.7.1.59

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-D-galactosamine 6-phosphate

738241

-

2.7.1.6

ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

721813, 759133, 759002

-

3.1.1.58

N-acetylgalactosamine + H2O = ?

646038

-

3.2.1.22

N-acetyl-D-galactosamine + melibiose = 6-O-alpha-D-galactosyl-N-acetyl-D-galactosamine + D-glucose

171187

-

3.5.1.33

N-acetyl-D-galactosamine + H2O = galactosamine + acetate

246601, 246604

-

Product in Enzyme-catalyzed Reactions (37 results)

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Show Product (37 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.3

acetyl-CoA + galactosamine = CoA + N-acetyl-D-galactosamine

0

-

2.4.1.211

beta D-galactosido-(1,3)-N-acetylgalactosamine + H2O = alpha-D-galactose-1-phosphate + GalNAc

0

-

2.4.1.211

beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosamine + phosphate = alpha-D-galactopyranose 1-phosphate + N-acetyl-D-galactosamine

0

-

2.4.1.211

beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-galactosamine

0

-

2.4.1.211

beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosmine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-galactosamine

0

-

2.4.1.211

galacto-N-biose + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-galactosamine

0

-

2.4.1.211

beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosmine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-galactosamine

0

-

3.1.6.12

N-acetyl-D-galactosamine 4-sulfate + H2O = N-acetyl-D-galactosamine + sulfate

0

-

3.1.6.12

N-acetyl-D-galactosamine 4-sulfate units + H2O = N-acetyl-D-galactosamine units + sulfate

0

-

3.1.6.12

N-acetylgalactosamine 4-sulfate + H2O = N-acetylgalactosamine + sulfate

0

-

2.4.1.211

6 entries

3.1.6.12

3 entries

3.1.6.14

N-acetyl galactosamine 6-sulfate + H2O = N-acetyl galactosamine + sulfate

0

-

3.1.6.4

N-acetylgalactosamine 6-sulfate + H2O = N-acetylgalactosamine + sulfate

0

-

3.2.1.217

4-methylumbelliferyl alpha-N-acetyl-D-galactosaminide + H2O = 4-methylumbelliferone + N-acetyl-D-galactosamine

0

-

3.2.1.217

4-nitrophenyl alpha-N-acetyl-D-galactosaminide + H2O = 4-nitrophenol + N-acetyl-D-galactosamine

0

-

3.2.1.217

BODIPY-IL29a peptide + H2O = N-acetyl-D-galactosamine + QPQPTAGPV

0

-

3.2.1.217

BSM + H2O = N-acetyl-D-galactosamine + ?

0

-

3.2.1.217

fetuin + H2O = N-acetyl-D-galactosamine + ?

0

-

3.2.1.217

mucin + H2O = N-acetyl-D-galactosamine + ?

0

-

3.2.1.217

Tn antigen + H2O = N-acetyl-D-galactosamine + ?

0

-

3.2.1.49

4-nitrophenyl alpha-D-N-acetylgalactosaminide + H2O = 4-nitrophenol + N-acetyl-D-galactosamine

0

-

3.2.1.49

o-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O = o-nitrophenol + N-acetyl-D-galactosamine

0

-

3.2.1.49

p-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O = p-nitrophenol + N-acetyl-D-galactosamine

0

-

3.2.1.49

4-nitrophenyl N-acetyl-D-galactosamine + H2O = 4-nitrophenol + N-acetyl-galactosamine

0

-

3.2.1.49

phenyl-alpha-N-acetylglucosaminide + H2O = N-acetylgalactosamine + phenol

208666

-

3.2.1.52

4-methylumbelliferyl N,N'-diacetyl-beta-D-chitobioside + 2 H2O = 4-methylumbelliferone + 2 N-acetylgalactosamine

0

-

3.2.1.52

p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside + H2O = 2-acetamido-2-deoxy-D-galactose + p-nitrophenol

393721, 136607, 393670, 393688, 393686, 393672, 393676, 393715, 393725, 393704, 393705, 393650, 393698, 393699, 393696, 393732, 393713, 393706, 393656, 393652, 393719, 393703, 393673, 393674, 393687, 393683, 393660, 393695, 393710, 393678, 393708, 393663, 393659, 393682, 393692, 393665, 136038, 393669, 393484, 393666, 393675, 393724, 393507, 393654, 393671, 0, 393657, 136606

-

3.2.1.52

globoside I + H2O = trihexaosylceramide + GalNAc

393663

-

3.2.1.52

globotetraosylceramide + H2O = globotriaosylceramide + GalNAc

393653

-

3.2.1.52

Sda oligosaccharide + H2O = N-acetyl-D-galactosamine

393654

-

3.2.1.52

SRO oligosaccharide + H2O = N-acetyl-D-galactosamine

393654

-

3.2.1.52

4-methylumbelliferyl N-acetyl-beta-D-galactosamine + H2O = 4-methylumbelliferone + N-acetylgalactosamine

0

-

3.2.1.52

4-nitrophenyl N-acetyl-beta-D-galactosamine + H2O = 4-nitrophenol + N-acetylgalactosamine

0

-

3.2.1.52

chondroitin 4-sulfate + H2O = N-acetylgalactosamine + ?

0

-

3.2.1.53

GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer + H2O = GalNAc + Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer

0

-

3.2.1.53

GalNAc-beta-1,4-Gal-beta-1,4-Glc-beta-1,1-Cer = GalNAc + Gal-beta-1,4-Glc-beta-1,1-Cer

0

-

3.2.1.53

4-nitrophenyl N-acetyl-beta-D-galactosaminopyranoside + H2O = N-acetyl-D-galactosamine + 4-nitrophenol

0

-

3.2.1.53

N-acetyl-beta-D-galactosaminides + H2O = N-acetyl-D-galactosamine + an alcohol

0, 136606, 136607

-

3.2.1.217

7 entries

3.2.1.49

5 entries

3.2.1.52

9 entries

3.2.1.53

4 entries

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.52

9% activation at 3 mM

710485

-

3.5.99.6

-

648232

-

Inhibitor in Enzyme-catalyzed Reactions (36 results)

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Show Inhibitors (36 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.3.9

competitive inhibition

389880

-

2.4.1.41

inhibition for GalNAc-T2 lectin domain to bind GalNAc-MUC1; inhibition for GalNAc-T4 lectin domain to bind GalNAc-MUC1

686971

-

2.4.1.41

inhibition of GalNAc-T1 by free GalNAc: follow-up O-glycosylation of apomucin is sensitive, O-glycosylation of synthetic peptides containing a single glycosylation site is resistant

489190

-

2.7.1.157

substrate inhibition

709300

-

2.7.1.157

substrate inhibition

709300

-

2.4.1.41

2 entries

2.7.1.157

2 entries

2.8.2.21

slight inhibition at 25 mM

645836

-

3.2.1.14

76.2% relative inhibition, three concentrations of 10, 50, and 100 mM tested

679943

-

3.2.1.169

an inhibitor of other hexosaminidases

706099

-

3.2.1.22

-

664176, 729607

-

3.2.1.49

-

707791

-

3.2.1.49

57% and 62% inhibition of isozyme alpha-GalNAcase I and isozyme alpha-GalNAcase II

707791

-

3.2.1.49

-

208650, 208652, 208661, 208665

-

3.2.1.52

-

393675

-

3.2.1.52

-

393507, 393670, 393695, 393700, 393715, 393722, 393732, 664773

-

3.2.1.52

45% inhibition at 20 mM

393659

-

3.2.1.52

60% inhibition with 1 mM

393726

-

3.2.1.52

80% inhibition with 100 mM

393671

-

3.2.1.52

competitive inhibitor

393650, 393675

-

3.2.1.52

competitive inhibitor; more potent than N-acetyl-D-glucosamine

393652

-

3.2.1.52

concentration of 10 mM causes 28% inhibition

393696

-

3.2.1.52

concentration of 10 mM causes 80% inhibition

393686

-

3.2.1.52

inhibits N-acetylhexosaminidase and -galactosaminidase

136607

-

3.2.1.52

inhibits N-galactosaminidase

136606

-

3.2.1.52

PI: concentration of 30 mM causes 69% inhibition, PII: concentration of 30 mM causes 80% inhibition

393709

-

3.2.1.52

with 10 mM 20% of activity remains

393678

-

3.2.1.52

with 10 mM 52.6% of activity remains

393703

-

3.2.1.52

with 10 mM the hydrolysis of p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside is reduced to 26%

393669

-

3.2.1.52

with 30 mM 12.1% activity of liver enzyme type S, 13.6% of brain enzyme type S, 3.2-8.6% of liver enzyme type A and 2.9-9.9% of liver enzyme type B remains

393668

-

3.2.1.52

with 60 mM 45% of activity remains

393692

-

3.2.1.52

61.9% relative inhibition, three concentrations of 10, 50, and 100 mM tested

679943

-

3.2.1.53

-

136606

-

3.2.1.53

competitive inhibition

136607

-

3.2.1.53

dose dependent inhibition, at lower levels than inhibition by N-acetylglucosamine, three concentrations of 10, 50, and 100 mM tested

679943

-

3.2.1.53

relative activity in presence of 10 mM 50%, in presence of 50 mM 12%

136608

-

3.2.1.49

3 entries

3.2.1.52

18 entries

3.2.1.53

4 entries

3.2.1.92

-

137009, 137011

-

3.2.2.22

minimum inhibition concentration is 4.2 mM

664265

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (8 results)

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Show Turnover Number (8 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.240

932

-

-

286366

2.4.1.211

34

-

-

693235

2.4.1.211

42

-

in 100 mM MOPS buffer (pH 7.0) at 37°C

701840

2.4.1.211

48

-

-

693235

2.7.1.157

1

-

recombinant enzyme

709300

2.7.1.157

2.5

-

pH 7.0, 25°C

704525

2.4.1.211

3 entries

2.7.1.157

2 entries

2.7.1.59

0.161

-

at pH 7.5 and 25°C

738241

2.7.1.6

0.36

-

pH 8.0, 45°C

721813

K_M Value (14 results)

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Show KM Value (14 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.240

0.8

-

-

286366

1.1.3.29

0.1

-

-

389762

1.1.3.29

0.32

-

pH 7.4, 25°C

762915

2.4.1.211

3.3

-

-

693235

2.4.1.211

11

-

in 100 mM MOPS buffer (pH 7.0) at 37°C

701840

1.1.3.29

2 entries

2.4.1.211

2 entries

2.4.1.38

850

-

-

489519

2.4.1.90

850

-

-

489519

2.7.1.157

0.04

-

recombinant enzyme

709300

2.7.1.157

0.12

-

pH 7.0, 25°C

704525

2.7.1.157

0.14

-

-

659129

2.7.1.157

3 entries

2.7.1.59

0.268

-

at pH 7.5 and 25°C

738241

2.7.1.6

15.76

-

pH 8.0, 45°C

721813

3.1.1.58

0.0159

-

35°C, pH 5

646038

3.1.1.58

0.0161

-

35°C, pH 9

646038

3.1.1.58

2 entries

K_i Value (6 results)

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Show KI Value (6 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.3.9

0.047

-

-

389880

2.4.1.41

68

-

inhibition of GalNAc-T1 mutant P-deltaN42

489190

2.4.1.41

175

-

inhibition of GalNAc-T1 mutant D444A

489190

2.4.1.41

2 entries

2.7.1.157

13

-

pH 8.0, 37°C

709300

3.2.1.52

0.21

-

in presence of 200 mM heptakis-(2,6-di-O-methyl)-beta-cyclodextrin

664773

3.2.1.52

1.19

-

-

664773

3.2.1.52

2 entries

IC₅₀ Value (4 results)

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Show IC50 Value (4 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.4.1.41

1

-

GalNAc-MUC1 binding to biotinylated GalNAc-T4

686971

2.4.1.41

5

-

GalNAc-MUC1 binding to biotinylated GalNAc-T4 lectin domain

686971

2.4.1.41

15

-

GalNAc-MUC1 binding to biotinylated GalNAc-T2

686971

2.4.1.41

37

-

GalNAc-MUC1 binding to biotinylated GalNAc-T2 lectin domain

686971

2.4.1.41

4 entries

References & Links

Literature References (108)

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Show Reference (108 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

136038

26672

Purification and characterization of beta-D-mannosidase and beta-N-acetyl-D-hexosaminidase of Tremella fuciformis

1978

Sone, Y.; Misaki, A.

J. Biochem.

83

1135-1144

136606

6222051

Neutral beta-N-acetylhexosaminidases of rat brain. Purification and enzymatic and immunological characterization

1983

Izumi, T.; Suzuki, K.

J. Biol. Chem.

258

6991-6999

136607

6055190

Isolation of beta-N-acetylhexosaminidase, beta-N-acetylglucosaminidase, and beta-N-acetylgalactosaminidase from calf brain

1967

Frohwein, Y.Z.; Gatt, S.

Biochemistry

6

2775-2782

136608

9378710

Purification and characterization of beta-N-acetylgalactosaminidase from Bacillus sp. AT173-1

1997

Tanaka, A.; Ozaki, S.

J. Biochem.

122

330-336

137009

6281

exo-beta-N-Acetylmuramidase - a novel hexosaminidase. Production by Bacillus subtilis B, purification and characterization

1976

Del Rio, L.A.; Berkeley, R.C.W.

Eur. J. Biochem.

65

3-12

137011

4201863

An enzyme from Bacillus subtilis B with exo-beta-N-acetylmuramidase activity

1973

Del Rio, L.A.; Berkeley, R.C.W.; Brewer, S.J.; Roberts, S.E.

FEBS Lett.

37

7-9

171187

4561015

Biochemistry of alpha-galactosidases

1972

Dey, P.M.; Pridham, J.B.

Adv. Enzymol. Relat. Areas Mol. Biol.

36

91-130

208650

-

Purification and characterization of alpha-N-acetylgalactosaminidase from shrimp hepatopancreas

1986

Chien, S.F.

J. Chin. Biochem. Soc.

15

86-96

208652

6746602

alpha-N-Acetylgalactosaminidase from squid liver: purification and characterization of two enzymes

1984

Itoh, T.; Uda, Y.

J. Biochem.

95

959-970

208661

18458

alpha-N-Acetylgalactosaminidase from the limpet, Patella vulgata

1977

Uda, Y.; Li, S.C.; Li, Y.T.

J. Biol. Chem.

252

5194-5200

208665

5785223

Mammalian alpha-acetylgalactosaminidase. Occurrence, partial purification, and action on linkages in submaxillary mucins

1969

Weissmann, B.; Hinrichsen, D.F.

Biochemistry

8

2034-2043

208666

5348072

Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase

1969

Werries, E.; Wollek, E.; Gottschalk, A.; Buddecke, E.

Eur. J. Biochem.

10

445-449

246601

13428742

Glucosamine metabolism. N-acetylglucosamine deacetylase

1957

Roseman, S.

J. Biol. Chem.

226

115-124

246604

27315721

Production of N-acetylglucosamine deacetylase by Vibrio cholerae non-O1

1994

Yamano, N.; Fujishima, S.; Miwatani, R.; Yuku, F.; Tanaka, R.; Arita, M.

Biosci. Biotechnol. Biochem.

58

193-195

286366

-

Purification and characterization of N-acetyl-D-hexosamine dehydrogenase from Pseudomonas sp. No. 53

1989

Horiuchi, T.; Kurokawa, T.

Agric. Biol. Chem.

53

1919-1925

389762

-

Purification and properties of N-acyl-D-hexosamine oxidase from Pseudomonas sp. 15-1

1989

Horiuchi, T.

Agric. Biol. Chem.

53

361-368

389866

-

Kinetic properties of galactose oxidase from Gibberella fujikuroi

1984

Aisaka, K.; Uwajima, T.; Terada, O.

Agric. Biol. Chem.

48

1425-1431

389871

6274348

Steric factors involved in the action of glycosidases and galactose oxidase

1981

Gathmann, W.D.; Aminoff, D.

Biochem. Biophys. Res. Commun.

103

68-76

389880

5752801

The inhibition of galactose oxidase

1968

Yip, M.C.M.; Dain, J.A.

Enzymologia

35

368-376

389881

-

Galactose oxidase of Polyporus circinatus

1966

Amaral, D.; Kelly-Falcoz, F.; Horecker, B.L.

Methods Enzymol.

9

87-92

389882

13863403

The D-galactose oxidase of Polyporus circinatus

1962

Avigad, G.; Amaral, D.; Asensio, C.; Horecker, B.L.

J. Biol. Chem.

237

2736-2743

393484

-

Chitinase and beta-N-acetylhexosaminidase from Pycnoporus cinnabarinus

1988

Ohtakara, A.

Methods Enzymol.

161

462-470

393507

7370275

Chitinase and beta-N-acetylglucosaminidase from the digestive fluid of the spider, Cupiennius salei

1980

Mommsen, T.P.

Biochim. Biophys. Acta

612

361-372

393650

-

Purification and properties of a wheat leaf N-acetyl-beta-D-hexosaminidase

1989

Barber, M.S.; Ride, J.P.

Plant Sci.

60

163-172

393652

-

beta-N-Acetylhexosaminidase from soybean

1988

Gers-Barlag, H.; Bartz, I.; Ruediger, H.

Phytochemistry

27

3739-3741

393653

2976757

Purification and characterization of beta-N-acetylhexosaminidase I from human placenta

1988

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1986

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Partial purification and characterization of a beta-N-acetylhexosaminidase from black cherry (Prunus serotina Ehrh.) seeds

1985

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Purification and characterization of beta-N-acetylhexosaminidase from Penicillium oxalicum

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1983

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Purification and characterization of beta-N-acetylhexosaminidase from Pycnoporus cinnabarinus

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Purification and characterization of thermostable beta-N-acetylhexosaminidase of Bacillus stearothermophilus CH-4 isolated from chitin-containing compost

1994

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1990

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Biochim. Biophys. Acta

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1990

Pocsi, I.; Kiss, L.; Zsoldos-Madi, V.; Pinter, I.

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Characteristics of hexosaminidase A in homogenates of white blood cells using methylumbelliferyl-N-acetyl-beta-D-glucosaminide-6-sulphate as substrate

1991

Den Tandt, W.R.; Scharpe, S.

Clin. Chim. Acta

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1987

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beta-N-Acetyl-D-glucosaminidases from integument of the silkworm, Bombyx mori: Comparative biochemistry with the pupal alimentary canal enzyme

1987

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Purification and properties of beta-N-acetyl-D-glucosaminidase from alimentary canal of the silkworm, Bombyx mori

1986

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beta-N-Acetylglucosaminidase from Phycomyces blakesleeanus

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Studies on Turbatrix aceti beta-N-acetylglucosaminidase. 1.Purification and physicochemical characterization

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Purification of pig gastric-mucosal N-acetyl-beta-D-glucosaminidase

1984

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Purification and characterization of a beta-N-acetylglucosaminidase from Octopus vulgaris. Determination of specificity by using 360-MHz 1H-NMR spectroscopy

1983

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1980

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Studies on the glycosidases of semen. Purification and properties of beta-N-acetylglucosaminidase from bull sperm

1977

Khar, A.; Anand, S.R.

Biochim. Biophys. Acta

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Vegetative isozyme of N-acetylglucosaminidase in Dictyostelium discoideum

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Isolation and characterization of the major beta-N-acetyl-D-glucosaminidase from human plasma

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An exo-beta-N-acetylglucosaminidase from Bacillus subtilis B. Characterization

1973

Berkeley, R.C.W.; Brewer, S.J.; Ortiz, J.M.; Gillespie, J.B.

Biochim. Biophys. Acta

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Partial purification and properties of a beta-N-acetylglucosaminidase from the fungus Sclerotina fructigena

1973

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Purification of two beta-N-acetyl-D-glucosaminidases from beef spleen

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Separation and characterization of N-acetyl-beta-glucosaminidases A and P from maternal serum

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Stirling, J.L.

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Studies on glucosaminidases. 3. Testicular N-acetyl-beta-D-glucosaminidase and N-acetyl-beta-D-galactosaminidase

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Human serum galactosyltransferase: distinction, separation and product identification of two galactosyltransferase activities

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Cloning, over-expression, purification, and characterization of N-acetylneuraminate synthase from Streptococcus agalactiae

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Purification and properties of UDP-Gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa

1982

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Co-purification of galactosyltransferases from chick-embryo liver

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Biosynthesis of marsupial milk oligosaccharides: characterization and developmental changes of two galactosyltransferases in lactating mammary glands of the tammar wallaby, Macropus eugenii

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Purification and characterization of N-acetylglucosaminyl sulfotransferase from chick corneas

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Purification and characterization of Neurospora crassa N-acetyl galactosaminoglycan deacetylase

1982

Jorge, J.A.; Kinney, S.G.; Reissig, J.L.

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Glucosamine 6-phosphate deaminase in normal human erythrocytes

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Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation

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Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease

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An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata

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Screening and characterization of beta-N-acetylhexosaminidases for the synthesis of nucleotide-activated disaccharides

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Glycolytic and chitinolytic activities of Phlebotomus papatasi (Diptera: Psychodidae) from diverse ecological habitats

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2007

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Photobacterium sp. JT-ISH-224 produces two sialyltransferases, alpha-/beta-galactoside alpha2,3-sialyltransferase and beta-galactoside alpha2,6-sialyltransferase

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Characterization of three beta-galactoside phosphorylases from clostridium phytofermentans: discovery of D-galactosyl-beta1,4-L-rhamnose phosphorylase

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Characterization of beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Propionibacterium acnes

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Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives

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One-pot enzymatic production of beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galactose (galacto-N-biose) from sucrose and 2-acetamido-2-deoxy-D-galactose (N-acetylgalactosamine)

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A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

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Chem. Commun. (Camb. )

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The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

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Stockbridge, R.B.; Wolfenden, R.

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O-GlcNAc-selective-N-acetyl-beta-D-glucosaminidase activity and mRNA expression in muscle is related to glucosamine-induced insulin resistance

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Duran-Reyes, G.; Pascoe-Lira, D.; Garcia-Macedo, R.; Medina-Navarro, R.; Rosales-Torres, A.M.; Vergara-Onofre, M.; Foyo-Niembro, E.; Gutierrez-Rodriguez, M.E.; Garcia-Gutierrez, M.T.; Valladares-Salgado, A.; Kumate, J.; Cruz, M.

Pharmacology

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Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis

2010

Harun-Or-Rashid, M.; Matsuzawa, T.; Satoh, Y.; Shiraishi, T.; Ando, M.; Sadik, G.; Uda, Y.

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Purification and characterization of a liver-derived beta-N-acetylhexosaminidase from marine mammal Sotalia fluviatilis

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Gomes Junior, J.E.; Souza, D.S.; Nascimento, R.M.; Lima, A.L.; Melo, J.A.; Rocha, T.L.; Miller, R.N.; Franco, O.L.; Grossi-de-Sa, M.F.; Abreu, L.R.

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Substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4 towards galactose, glucose, and their derivatives

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Comparison between alpha-galactosidase A activity in blood samples collected on filter paper, leukocytes and plasma

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Clin. Biochem.

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Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes

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Wang, K.C.; Lyu, S.Y.; Liu, Y.C.; Chang, C.Y.; Wu, C.J.; Li, T.L.

Acta Crystallogr. Sect. D

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Identification of an N-acetylglucosamine kinase essential for UDP-N-acetylglucosamine salvage synthesis in Arabidopsis

2015

Furo, K.; Nozaki, M.; Murashige, H.; Sato, Y.

FEBS Lett.

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A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis

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Large scale production of lacto-N-biose I, a building block of type I human milk oligosaccharides, using sugar phosphorylases

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Nishimoto, M.

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The characterisation of a galactokinase from Streptomyces coelicolor

2019

Keenan, T.; Mills, R.; Pocock, E.; Budhadev, D.; Parmeggiani, F.; Flitsch, S.; Fascione, M.

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Substrate specificity of the galactokinase from the human gut symbiont Akkermansia muciniphila ATCC BAA-835

2020

Zhang, X.; Sheng, W.; Li, K.; Rong, Y.; Wu, Q.; Meng, Q.; Kong, Y.; Chen, M.

Enzyme Microb. Technol.

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A description of enzymatic catalysis in N-acetylhexosamine 1-kinase concerted mechanism of two-magnesium-ion-assisted GlcNAc phosphorylation, flexibility behavior of lid motif upon substrate recognition, and water-assisted GlcNAc-1-P release

2018

Zhao, Y.; She, N.; Ma, Y.; Wang, C.; Cao, Z.

ACS Catal.

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762915

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Discovery of two novel oxidases using a high-throughput activity screen

2022

Rembeza, E.; Boverio, A.; Fraaije, M.W.; Engqvist, M.K.M.

Chembiochem

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