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Characterization of heparin low-affinity phospholipase A1 present in brain and testicular tissue
1999
Uchiyama, S.I.; Miyazaki, Y.; Amakasu, Y.; Kuwata, H.; Nakatani, Y.; Atsumi, G.I.; Murakami, M.; Kudo, I.
J. Biochem.
125
1001-1010
A silent ABC transporter isolated from Streptomyces rochei F20 induces multidrug resistance
1998
Fernandez-Moreno, M.A.; Carbo, L.; Cuesta, T.; Vallin, C.; Malpartida, F.
J. Bacteriol.
180
4017-4023
Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2-amino group of aminoglycoside antibiotics
1974
Chevereau, M.; Daniels, P.J.L.; Davies, J.; LeGoffic, F.
Biochemistry
13
598-603
Characterization of gentamicin 2'-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan
1997
Payie, K.G.; Clarke, A.J.
J. Bacteriol.
179
4106-4114
Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron
2003
Riccio, M.L.; Docquier, J.D.; Dell'Amico, E.; Luzzaro, F.; Amicosante, G.; Rossolini, G.M.
Antimicrob. Agents Chemother.
47
1746-1748
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor
1971
Benveniste, R.; Davies, J.
Biochemistry
10
1787-1796
Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase
1974
Le Goffic, F.; Martel, A.
Biochimie
56
893-897
Characterization of aminoglycoside 6-N-acetyltransferases [AAC(6)] from gram-negative bacteria and Streptomyces kanamyceticus
1985
Meyer, J.F.; Wiedemann, B.
J. Antimicrob. Chemother.
15
271-282
Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL. Relationship between the two activities
1983
Martel, A.; Masson, M.; Moreau, N.; Le Goffic, F.
Eur. J. Biochem.
133
515-521
Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6-N-acetyltransferase Ib and IIa proteins
1992
Rather, P.N.; Munayyer, H.; Mann, P.A.; Hare, R.S.; Miller, G.H.; Shaw, K.J.
J. Bacteriol.
174
3196-3203
pH Modulation of aminoglycoside resistance in Staphylococcus epidermidis harboring 6'-N-aminoglycoside acetyltransferase
1996
Culebras, E.; Martinez, J.L.; Baquero, F.; Perez-Diaz, J.C.
J. Antimicrob. Chemother.
37
881-889
A spontaneous point mutation in the aac(6')-Ib gene results in altered substrate specificity of aminoglycoside 6'-N-acetyltransferase of a Pseudomonas fluorescens strain
1994
Lambert, T.; Ploy, M.C.; Courvalin, P.
FEMS Microbiol. Lett.
115
297-304
Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides
1999
Chavideh, R.; Sholly, S.; Panaite, D.; Tolmasky, M.E.
Antimicrob. Agents Chemother.
43
2811-2812
Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium
1997
Wright, G.D.; Ladak, P.
Antimicrob. Agents Chemother.
41
956-960
Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase
2001
Magnet, S.; Lambert, T.; Courvalin, P.; Blanchard, J.S.
Biochemistry
40
3700-3709
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate
1976
Biddlecome, S.; Haas, M.; Davies, J.; Rane, D.F.; Daniels, P.J.L.
Antimicrob. Agents Chemother.
9
951-955
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa
1982
Angelatou, F.; Litsas, S.B.; Kontomichalou, P.
J. Antibiot.
35
235-244
Kinetic mechanisms of gentamicin acetyltransferase I. Antibiotic-dependent shift from rapid to nonrapid equilibrium random mechanisms
1978
Williams, J.W.; Northrop, D.B.
J. Biol. Chem.
253
5902-5907
Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values
1978
Williams, J.W.; Northrop, D.B.
J. Biol. Chem.
253
5908-5914
Effects of antibiotics, N-acetylaminoacyl-tRNA and other agents on the elongation-factor Tu dependent and ribosome-dependent GTP hydrolysis promoted by 2'(3')-O-L-phenylalanyladenosine
1981
Campuzano, S.; Modolell, J.
Eur. J. Biochem.
117
27-31
Aminoglycoside-modifying enzymes
1975
Haas, M.J.; Dowding, J.E.
Methods Enzymol.
43
611-627
Purification and properties of gentamicin nucleotidyltransferase from Escherichia coli: nucleotide specificity, pH optimum, and the separation of two electrophoretic variants
1984
Van Pelt, J.E.; Northrop, D.B.
Arch. Biochem. Biophys.
230
250-263
Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism
1988
Gates, C.A.; Northrop, D.B.
Biochemistry
27
3826-3833
1H, 13C, and 31P nuclear magnetic resonance spectral assignments for tobramycin, 2"-(adenosine-5'-phosphoryl)-tobramycin and 2"-(adenosine-5'-thiophosphoryl)-tobramycin
1990
Van Pelt, J.E.; Mooberry, E.S.; Frey, P.A.
Arch. Biochem. Biophys.
280
284-291
Inhibition of Klenow DNA polymerase and poly(A)-specific ribonuclease by aminoglycosides
2002
Ren, Y.G.; Martinez, J.; Kirsebom, L.A.; Virtanen, A.
RNA
8
1393-1400
Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation
2004
Draker, K.A.; Wright, G.D.
Biochemistry
43
446-454
Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147
2004
Hamano, Y.; Hoshino, Y.; Nakamori, S.; Takagi, H.
J. Biochem.
136
517-524
Purification and properties of an aminoglycoside acetyltransferase from Pseudomonas aeruginosa
1982
Coombe, R.G.; George, A.M.
Biochemistry
21
871-875
Kinetic mechanism of streptomycin adenylyltransferase from a recombinant Escherichia coli
2005
Jana, S.; Deb, J.K.
Biotechnol. Lett.
27
519-524
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
2002
Jones, A.; Elphick, H.; Pettitt, E.; Everard, M.L.; Evans, G.S.
Eur. Respir. J.
19
1136-1141
The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli
2005
Magalhaes, M.L.; Blanchard, J.S.
Biochemistry
44
16275-16283
The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility
2007
Marr, A.K.; Overhage, J.; Bains, M.; Hancock, R.E.
Microbiology
153
474-482
Detection of broad-spectrum aminoglycoside antibiotics through fluorescence-labeling aminoglycoside acetyltransferase(6)-Ii
2008
Chu, X.; Wu, L.; Liu, X.; Li, N.; Li, D.
Anal. Biochem.
376
144-150
Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6-N-acetyltransferase
2008
Magalhaes, M.L.; Vetting, M.W.; Gao, F.; Freiburger, L.; Auclair, K.; Blanchard, J.S.
Biochemistry
47
579-584
Inhibition of poly(A) polymerase by aminoglycosides
2007
Thuresson, A.; Kirsebom, L.A.; Virtanen, A.
Biochimie
89
1221-1227
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin
2005
McClerren, A.L.; Endsley, S.; Bowman, J.L.; Andersen, N.H.; Guan, Z.; Rudolph, J.; Raetz, C.R.
Biochemistry
44
16574-16583
Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides
2010
Green, K.D.; Chen, W.; Houghton, J.L.; Fridman, M.; Garneau-Tsodikova, S.
ChemBioChem
11
119-126
Functional studies of rat galactokinase
2009
Chu, X.; Li, N.; Liu, X.; Li, D.
J. Biotechnol.
141
142-146
Thermodynamics and kinetics of association of antibiotics with the aminoglycoside acetyltransferase (3)-IIIb, a resistance-causing enzyme
2010
Norris, A.L.; Ozen, C.; Serpersu, E.H.
Biochemistry
49
4027-4035
The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction
2012
Parthier, C.; Görlich, S.; Jaenecke, F.; Breithaupt, C.; Bräuer, U.; Fandrich, U.; Clausnitzer, D.; Wehmeier, U.; Böttcher, C.; Scheel, D.; Stubbs, M.
Angew. Chem. Int. Ed. Engl.
51
4046-4052
Novel aminoglycoside 2-phosphotransferase identified in a gram-negative pathogen
2013
Toth, M.; Frase, H.; Antunes, N.T.; Vakulenko, S.B.
Antimicrob. Agents Chemother.
57
452-457
Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus
2008
Badarau, A.; Shi, Q.; Chow, J.W.; Zajicek, J.; Mobashery, S.; Vakulenko, S.
J. Biol. Chem.
283
7638-7647
Structural basis for dual nucleotide selectivity of aminoglycoside 2-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases
2012
Shi, K.; Berghuis, A.M.
J. Biol. Chem.
287
13094-13102
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme
2012
Frase, H.; Toth, M.; Vakulenko, S.
J. Biol. Chem.
287
43262-43269
Novel 6'-N-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa
2013
Tada, T.; Miyoshi-Akiyama, T.; Shimada, K.; Shimojima, M.; Kirikae, T.
Antimicrob. Agents Chemother.
57
96-100
Identification of a novel 6-N-aminoglycoside acetyltransferase, AAC(6)-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia
2014
Tada, T.; Miyoshi-Akiyama, T.; Dahal, R.K.; Mishra, S.K.; Shimada, K.; Ohara, H.; Kirikae, T.; Pokhrel, B.M.
Antimicrob. Agents Chemother.
58
6324-6327
Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts
2015
Li, Y.; Green, K.D.; Johnson, B.R.; Garneau-Tsodikova, S.
Antimicrob. Agents Chemother.
59
4148-4156
AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum
2015
Galimand, M.; Fishovitz, J.; Lambert, T.; Barbe, V.; Zajicek, J.; Mobashery, S.; Courvalin, P.
Antimicrob. Agents Chemother.
59
5647-5653
Protein dynamics are influenced by the order of ligand binding to an antibiotic resistance enzyme
2014
Norris, A.L.; Nickels, J.; Sokolov, A.P.; Serpersu, E.H.
Biochemistry
53
30-38
Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens
2013
Green, K.; Garneau-Tsodikova, S.
Biochimie
95
1319-1325
New plasmid-mediated aminoglycoside 6-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate
2015
Jin, W.; Wachino, J.; Kimura, K.; Yamada, K.; Arakawa, Y.
J. Antimicrob. Chemother.
70
1331-1337
Primary amine oxidase of Escherichia coli is a metabolic enzyme that can use a human leukocyte molecule as a substrate
2015
Elovaara, H.; Huusko, T.; Maksimow, M.; Elima, K.; Yegutkin, G.G.; Skurnik, M.; Dobrindt, U.; Siitonen, A.; McPherson, M.J.; Salmi, M.; Jalkanen, S.
PLoS ONE
10
e0142367
Primary amine oxidase of Escherichia coli is a metabolic enzyme that can use a human leukocyte molecule as a substrate
2015
Elovaara, H.; Huusko, T.; Maksimow, M.; Elima, K.; Yegutkin, G.G.; Skurnik, M.; Dobrindt, U.; Siitonen, A.; McPherson, M.J.; Salmi, M.; Jalkanen, S.
PLoS ONE
10
e0142367
Concentrated biosynthesis of tobramycin by genetically engineered Streptomyces tenebrarius
2014
Xiao, J.; Li, H.; Wen, S.; Hong, W.
J. Gen. Appl. Microbiol.
60
256-261
Concentrated biosynthesis of tobramycin by genetically engineered Streptomyces tenebrarius
2014
Xiao, J.; Li, H.; Wen, S.; Hong, W.
J. Gen. Appl. Microbiol.
60
256-261
Structural and biochemical characterization of Acinetobacter spp. aminoglycoside acetyltransferases highlights functional and evolutionary variation among antibiotic resistance enzymes
2017
Stogios, P.; Kuhn, M.; Evdokimova, E.; Law, M.; Courvalin, P.; Savchenko, A.
ACS Infect. Dis.
3
132-143
Structural and biochemical characterization of Acinetobacter spp. aminoglycoside acetyltransferases highlights functional and evolutionary variation among antibiotic resistance enzymes
2017
Stogios, P.; Kuhn, M.; Evdokimova, E.; Law, M.; Courvalin, P.; Savchenko, A.
ACS Infect. Dis.
3
132-143
Structural and functional survey of environmental aminoglycoside acetyltransferases reveals functionality of resistance enzymes
2017
Xu, Z.; Stogios, P.J.; Quaile, A.T.; Forsberg, K.J.; Patel, S.; Skarina, T.; Houliston, S.; Arrowsmith, C.; Dantas, G.; Savchenko, A.
ACS Infect. Dis.
3
653-665
Structural and functional survey of environmental aminoglycoside acetyltransferases reveals functionality of resistance enzymes
2017
Xu, Z.; Stogios, P.J.; Quaile, A.T.; Forsberg, K.J.; Patel, S.; Skarina, T.; Houliston, S.; Arrowsmith, C.; Dantas, G.; Savchenko, A.
ACS Infect. Dis.
3
653-665
Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im
2017
Smith, C.; Bhattacharya, M.; Toth, M.; Stewart, N.; Vakulenko, S.
Microb. Cell
4
402-410
A novel 6'-N-aminoglycoside acetyltransferase, AAC(6)-Ial, from a clinical isolate of Serratia marcescens
2016
Tada, T.; Miyoshi-Akiyama, T.; Shimada, K.; Dahal, R.; Mishra, S.; Ohara, H.; Kirikae, T.; Pokhrel, B.
Microb. Drug Resist.
22
103-108
Thermodynamics of an aminoglycoside modifying enzyme with low substrate promiscuity The aminoglycoside N3 acetyltransferase-VIa
2017
Kumar, P.; Serpersu, E.
Proteins
85
1258-1265
Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases
2017
Leban, N.; Kaplan, E.; Chaloin, L.; Godreuil, S.; Lionne, C.
Biochim. Biophys. Acta
1861
3464-3473
-
Aminoglycoside phosphotransferase AphSR2 from Streptomyces rimosus ATCC 10970 dependence of antibiotic Resistance on serine-threonine protein kinases PkSR1 and PkSR2
2020
Rudakova, N.; Alekseeva, M.; Zakharevich, N.; Mavletova, D.; Danilenko, V.
Russ. J. Genet.
56
112-117
Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action
2022
Milicaj, J.; Hassan, B.; Cote, J.; Ramirez-Mondragon, C.; Jaunbocus, N.; Rafalowski, A.; Patel, K.; Castro, C.; Muthyala, R.; Sham, Y.; Taylor, E.
Sci. Rep.
12
7302
Genome sequence of Streptomyces cavourensis BUU135, isolated from soil from a tropical fruit farm in Thailand
2021
Tangwattanachuleeporn, M.; Ruangsuj, P.; Yamprayoonswat, W.; Sittihan, S.; Jumpathong, W.; Yasawong, M.
Microbiol. Resour. Announc.
10
e01428-20
Recombinant human carbonic anhydrase VII Purification, characterization, inhibition, and molecular docking studies
2023
Duran, H.E.; Beydemir, S.
Biotechnol. Appl. Biochem.
70
415-428
Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening
2023
Huynh, T.N.; Shukla, S.; Reigan, P.; Parker, R.
Sci. Rep.
13
5244
Aminoglycoside 6-N-acetyltransferase Type Ib [AAC(6)-Ib]-mediated aminoglycoside resistance phenotypic conversion to susceptibility by silver ions
2020
Reeves, C.M.; Magallon, J.; Rocha, K.; Tran, T.; Phan, K.; Vu, P.; Yi, Y.; Oakley-Havens, C.L.; Cedano, J.; Jimenez, V.; Ramirez, M.S.; Tolmasky, M.E.
Antibiotics (Basel)
10
29
Identification and characterization of a novel 6-N-aminoglycoside acetyltransferase AAC(6)-Va from a clinical isolate of Aeromonas hydrophila
2023
Zhang, G.; Zhang, L.; Sha, Y.; Chen, Q.; Lin, N.; Zhao, J.; Zhang, Y.; Ji, Y.; Jiang, W.; Zhang, X.; Li, Q.; Lu, J.; Lin, X.; Li, K.; Zhang, H.; Bao, Q.; Lu, J.; Hu, Y.; Zhu, T.
Front. Microbiol.
14
1229593
Stenotrophomonas maltophilia from Nepal producing two novel antibiotic inactivating enzymes, a class A beta-lactamase KBL-1 and an aminoglycoside 6-N-acetyltransferase AAC(6)-Iap
2022
Kawauchi, R.; Tada, T.; Sherchan, J.B.; Shrestha, S.; Tohya, M.; Hishinuma, T.; Kirikae, T.; Sherchand, J.B.
Microbiol. Spectr.
10
e0114322
Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa
2022
Zielinski, M.; Blanchet, J.; Hailemariam, S.; Berghuis, A.M.
PLoS ONE
17
e0269684
Structural and biochemical analyses of an aminoglycoside 2-N-acetyltransferase from Mycolicibacterium smegmatis
2020
Jeong, C.S.; Hwang, J.; Do, H.; Cha, S.S.; Oh, T.J.; Kim, H.J.; Park, H.H.; Lee, J.H.
Sci. Rep.
10
21503