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BRENDA support

Ligand L-Theanine

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Basic Ligand Information

Molecular Structure
Picture of L-Theanine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H14N2O3
L-Theanine
DATAGRPVKZEWHA-YFKPBYRVSA-N
Synonyms:
(S)-2-amino-5-(ethylamino)-5-oxopentanoic acid, 5-L-glutamyl-ethylamine, gamma-glutamylethylamine, L-gamma-glutamyl-ethylamine, L-N5-Ethylglutamine, N-(gamma-L-glutamyl)ethylamine, N-ethyl-L-glutamine, N5-Ethyl-L-glutamine, Ngamma-ethyl-L-glutamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
-
ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-gamma-glutamyl-ethylamine = ?
show the reaction diagram
-
N-(gamma-L-glutamyl)ethylamine + H2O = L-glutamate + ethylamine
show the reaction diagram
-
L-theanine + H2O = L-glutamate + ethylamine
show the reaction diagram
-
N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine
show the reaction diagram
-
5-L-glutamyl-ethylamine = 5-oxoproline + ethylamine
show the reaction diagram
-
L-Theanine = D-Theanine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
-
ATP + L-Glu + ethylamine = ADP + phosphate + N-ethyl-L-glutamine
show the reaction diagram
-
ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation and induction
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
theanine, slight inhibition, 20 mM: 14% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.038
-
pH and temperature not specified in the publication
0.038
-
pH and temperature not specified in the publication

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.36
-
pH and temperature not specified in the publication
0.71
-
glutaminase B
5.8
-
partial purified enzyme
0.36
-
pH and temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.58
-
37°C, pH 7.5

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
24
-
37°C, pH 7.5

References & Links

Links to other databases for L-Theanine

ChEBI
PubChem
ChEBI
PubChem