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Ligand itaconyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.56

itaconyl-CoA + H2O = (S)-citramalyl-CoA

728354

-

4.2.1.56

Itaconyl-CoA + H2O = ?

5793

-

4.2.1.56

Itaconyl-CoA + H2O = Citramalyl-CoA

746855, 746828

-

4.2.1.56

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.2.1.5

ATP + itaconate + CoA = ADP + phosphate + itaconyl-CoA

0

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.56

itaconyl-CoA + H2O = (S)-citramalyl-CoA

728354

-

4.2.1.56

Itaconyl-CoA + H2O = ?

5793

-

4.2.1.56

Itaconyl-CoA + H2O = Citramalyl-CoA

5793, 746828, 746855

-

4.2.1.56

3 entries

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.56

(S)-citramalyl-CoA = itaconyl-CoA + H2O

0

-

4.2.1.56

mesaconyl-C4-CoA + H2O = itaconyl-CoA

0

-

4.2.1.56

2 entries

6.2.1.4

GTP + itaconate + CoA = GDP + phosphate + itaconyl-CoA

0

-

6.2.1.5

ATP + itaconate + CoA = ADP + phosphate + itaconyl-CoA

0

-

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.2.1.56

0.034

-

at pH 7.5 and 45°C

728354

4.2.1.56

0.12

-

at pH 7.5 and 45°C

728354

4.2.1.56

2 entries

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

5793

4284209

The utilization of itaconate by Pseudomonas sp.

1964

Cooper, R.A.; Kornberg, H.L.

Biochem. J.

91

82-91

728354

24657929

Bacterial itaconate degradation promotes pathogenicity

2014

Sasikaran, J.; Ziemski, M.; Zadora, P.K.; Fleig, A.; Berg, I.A.

Nat. Chem. Biol.

10

371-377

746828

26070669

Mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans

2015

Kronen, M.; Sasikaran, J.; Berg, I.A.

Appl. Environ. Microbiol.

81

5632-5638

746855

27102125

Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus

2016

Chen, M.; Huang, X.; Zhong, C.; Li, J.; Lu, X.

Appl. Microbiol. Biotechnol.

100

7541-7548

Links to other databases for itaconyl-CoA

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Show Links (1 entry)

ChEBI

PubChem

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