Ligand guanosine 3'-diphosphate 5'-triphosphate

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Basic Ligand Information

Molecular Structure
Picture of guanosine 3'-diphosphate 5'-triphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H18N5O20P5
guanosine 3'-diphosphate 5'-triphosphate
KCPMACXZAITQAX-UUOKFMHZSA-N
Synonyms:
guanosine-3'-diphosphate-5'-triphosphate, guanosine 3'-diphosphate-5'-triphosphate, guanosine 5'-triphosphate,3'-diphosphate, guanosine 5'-triphosphate 3'-diphosphate, pppGpp


Show all pahtways known for Show all BRENDA pathways known for guanosine 3'-diphosphate 5'-triphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pppGpp + H2O = pppG + diphosphate
show the reaction diagram
-
guanosine 3'-diphosphate 5'-triphosphate + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
guanine nucleotides, guanosinetriphosphate and polyphosphate derivatives, effective activation
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
-
inhibitory, impedes primase activity by blocking entry of an incoming NTP, and interfering with the binding of either an initiating 5'-NTP, or the extensible 3'-end of an RNA-DNA heteroduplex
-
inhibits LdcI only at pH values higher than 6.5
-

3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2
-
pH 7.5, 37°C, recombinant enzyme
0.0087
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0025
-
at pH 7.6 and 25°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0564
-
at pH 7.6 and 25°C
0.098
-
37°C, pH not specified in the publication

References & Links

Links to other databases for guanosine 3'-diphosphate 5'-triphosphate

ChEBI
PubChem
ChEBI
PubChem