Ligand N-acetyl-D-mannosamine

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Basic Ligand Information

Molecular Structure
Picture of N-acetyl-D-mannosamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H15NO6
N-acetyl-D-mannosamine
OVRNDRQMDRJTHS-ZTVVOAFPSA-N
Synonyms:
2-(acetylamino)-2-deoxy-D-mannopyranose, 2-acetamido-2-deoxy-D-mannose, ManNAc, N-acetylmannosamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-D-mannosamine + NAD+ = N-acetyl-D-mannosaminolactone + NADH + H+
show the reaction diagram
-
ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate
show the reaction diagram
-
N-acetyl-D-mannosamine = N-acetyl-D-glucosamine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-D-mannosamine + UDP
show the reaction diagram
-
-
N-acetyl-D-glucosamine = N-acetyl-D-mannosamine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-D-mannosamine + NAD+ = N-acetyl-D-mannosaminolactone + NADH + H+
show the reaction diagram
-
N-acetyl-D-mannosamine + NAD+ + H2O = N-acetyl-D-mannosaminate + NADH + H+
show the reaction diagram
-
N-acetyl-D-mannosamine + O2 = N-acetyl-D-mannosaminolactone + H2O2
show the reaction diagram
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ATP + N-acetyl-D-mannosamine = ADP + N-acetyl-D-mannosamine 6-phosphate
show the reaction diagram
-
N-acetyl-D-mannosamine + pyruvate = D-sialic acid
show the reaction diagram
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N-acetyl-D-mannosamine = N-acetyl-D-glucosamine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-D-mannosamine + UDP
show the reaction diagram
-
-
Man-(beta1-4)ManNAc + H2O = mannose + ManNAc
show the reaction diagram
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D-sialic acid = N-acetyl-D-mannosamine + pyruvate
show the reaction diagram
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-
N-acetyl-D-glucosamine = N-acetyl-D-mannosamine
show the reaction diagram
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-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates neuraminidase synthesis and activity about 8fold after 24 h
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.07 mM, 50% inhibition
-
competitive inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.1
-
in 50 mM Tris-HCl, pH 7.8, at 37C

KM Value (59 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
40
-
-
181
-
in 50 mM Tris-HCl, pH 7.8, at 37C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
50
-
at 37C, pH 7.4
75
-
pH 7.5, 25C

References & Links

Links to other databases for N-acetyl-D-mannosamine

ChEBI
PubChem
ChEBI
PubChem