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Ligand deoxycholoyl-CoA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C4 5 H7 4 N7 O1 9 P3 S
deoxycholoyl-CoA
YTGXPYMXYISPEB-SIQRDODDSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (7 results)
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deoxycholoyl-CoA + NAD(P)+ = 3-oxodeoxycholoyl-CoA + NAD(P)H + H+
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deoxycholoyl-CoA + NAD+ = 3-oxodeoxycholoyl-CoA + NADH + H+
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deoxycholoyl-CoA + aminomethanesulfonate = CoA + aminomethanesulfonyldeoxycholate
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deoxycholoyl-CoA + glycine = CoA + glycodeoxycholate
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deoxycholoyl-CoA + taurine = CoA + taurodeoxycholate
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deoxycholoyl-CoA + allocholate = deoxycholate + allocholoyl-CoA
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deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA
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Product in Enzyme-catalyzed Reactions (1 result)
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ATP + deoxycholate + CoA = AMP + diphosphate + deoxycholoyl-CoA
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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0.16
-
wild type enzyme isoform BaiA2, at pH 8.7 and 37°C
0.87
-
wild type enzyme isoform BaiA1, at pH 8.7 and 37°C
KM Value (2 results)
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0.016
-
wild type enzyme isoform BaiA1, at pH 8.7 and 37°C
0.017
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wild type enzyme isoform BaiA2, at pH 8.7 and 37°C
References & Links Literature References (6)
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Expression in Escherichia coli and characterization of a bile acid-inducible 3alpha-hydroxysteroid dehydrogenase from Eubacterium sp. strain VPI 12708
1995
Mallonee, D.H.; Lijewski, M.A.; Hylemon, P.B.
Curr. Microbiol.
30
259-263
Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver
1980
Czuba, B.; Vessey, D.A.
J. Biol. Chem.
255
5296-5299
Purification and characterization of amino-acid N-choloyltransferase from human liver
1983
Kimura, M.; Okuno, E.; Inada, J.; Ohyama, H.; Kido, R.
Hoppe-Seyler's Z. Physiol. Chem.
364
637-645
Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from rat liver
1978
Killenberg, P.G.; Jordan, J.T.
J. Biol. Chem.
253
1005-1010
Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7alpha-dehydroxylating intestinal bacterium
2012
Ridlon, J.; Hylemon, P.
J. Lipid Res.
53
66-76
Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe
2014
Bhowmik, S.; Jones, D.H.; Chiu, H.P.; Park, I.H.; Chiu, H.J.; Axelrod, H.L.; Farr, C.L.; Tien, H.J.; Agarwalla, S.; Lesley, S.A.
Proteins
82
216-229
Links to other databases for deoxycholoyl-CoA
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