Ligand deoxyuridine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of deoxyuridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H12N2O5
deoxyuridine
MXHRCPNRJAMMIM-SHYZEUOFSA-N
Synonyms:
1-(2-deoxy-beta-D-ribofuranosyl)uracil, 2'-deoxy-D-ribosyl-uracil, 2'-deoxyuridine, 2'-deoxyuridne, 2'deoxyuridine, 2-deoxyuridylate, D-deoxyuridine, deoxy-5-hydroxyuridine


Show all pahtways known for Show all BRENDA pathways known for deoxyuridine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
-
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
2'-deoxy-D-ribosyl-uracil + adenine = 2'-deoxy-D-ribosyl-adenine + uracil
show the reaction diagram
-
ATP + 2'-deoxyuridine = ADP + 2'-deoxyuridine 5'-phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uracil + 2-deoxy-alpha-D-ribose 1-phosphate = 2'-deoxyuridine + phosphate
show the reaction diagram
-
-
5'-dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
deoxycytidine + H2O = deoxyuridine + NH3
show the reaction diagram
-
-
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + Br- + H2O2 = 5-bromo-2'-deoxyuridine + H2O
show the reaction diagram
-
2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
-
2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2
show the reaction diagram
-
AMP + deoxyuridine = adenosine + deoxyuridine 5'-phosphate
show the reaction diagram
-
phenyl phosphate + deoxyuridine = dUMP + phenol
show the reaction diagram
-
p-nitrophenyl phosphate + 2'-deoxyuridine = ?
show the reaction diagram
-
2'-deoxyuridine + H2O = uracil + 2-deoxy-D-ribose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uracil + 2-deoxy-alpha-D-ribose 1-phosphate = 2'-deoxyuridine + phosphate
show the reaction diagram
-
-
2'-deoxy-uridine 5'-phosphate + trans-farnesyl diphosphate = 2'-deoxyuridine + trans-farnesyl triphosphate
show the reaction diagram
-
-
2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate
show the reaction diagram
-
-
dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
5'-dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
deoxycytidine + H2O = deoxyuridine + NH3
show the reaction diagram
-
-
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reaction with thymidine and 2'-deoxycytidine
-

3D Structure of Enzyme-Ligand-Complex (PDB) (92 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
24.6
-
pH 7.6, 37°C
35
-
-
483
-
pH 6.5, 40°C

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.19
-
-
1.14
-
pH 6.5, 40°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for deoxyuridine

ChEBI
PubChem
-
PubChem