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Ligand 7-methyl-GTP

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.6.4.13

7-methyl-GTP + H2O = 7-methyl-GDP + phosphate

713144

-

5.6.1.6

7-methyl-GTP + H2O + closed Cl- channel = 7-methyl-GDP + phosphate + open Cl- channel

751114

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.56

S-adenosyl-L-methionine + GTP = S-adenosyl-L-homocysteine + m7GTP

0, 485473, 485451

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Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.1.17

stimulates

4021

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.50

-

739454

-

3.5.4.16

36% inhibition at 2 mM GMP

685163

-

3.5.4.39

included along with 2 mM GTP in the incubation mixture. 36% inhibition

685163

-

3.6.1.62

inhibits decapping at large molar ratios relative to capped RNA substrate

716742

-

3.6.4.13

-

713144

-

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.6.4.13

1

-

pH 7.5, 37°C, wild-type enzyme, inhibition of the ATPase reaction

713144

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.6.1.62

0.003

-

pH 7.5, 37°C

716742

3.6.4.13

1.4

-

pH 7.5, 37°C, wild-type enzyme, inhibition of the ATPase reaction

713144

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4021

6824682

Ornithine decarboxylase activity from an extremely thermophilic bacterium, Clostridium thermohydrosulfuricum

1983

Paulin, L.; Poesoe, H.

Biochim. Biophys. Acta

742

197-205

485451

6649413

Identification of a unique guanine-7-methyltransferase in Semliki Forest virus (SFV) infected cell extracts

1983

Cross, R.K.

Virology

130

452-463

485473

11134291

Characterization of the Adomet-dependent guanylyltransferase activity that is associated with the N terminus of bamboo mosaic virus replicase

2001

Li, Y.I.; Chen, Y.J.; Hsu, Y.H.; Meng, M.

J. Virol.

75

782-788

685163

17497938

Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii

2007

Grochowski, L.L.; Xu, H.; Leung, K.; White, R.H.

Biochemistry

46

6658-6667

713144

20421212

Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase

2010

Despins, S.; Issur, M.; Bougie, I.; Bisaillon, M.

Nucleic Acids Res.

38

5493-5506

716742

17283339

Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression

2007

Parrish, S.; Resch, W.; Moss, B.

Proc. Natl. Acad. Sci. USA

104

2139-2144

739454

27427769

A sensitive and robust high-throughput screening assay for inhibitors of the Chikungunya virus nsP1 capping enzyme

2016

Bullard-Feibelman, K.M.; Fuller, B.P.; Geiss, B.J.

PLoS ONE

11

e0158923

751114

29903914

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

2018

Wang, C.; Aleksandrov, A.A.; Yang, Z.; Forouhar, F.; Proctor, E.A.; Kota, P.; An, J.; Kaplan, A.; Khazanov, N.; Boel, G.; Stockwell, B.R.; Senderowitz, H.; Dokholyan, N.V.; Riordan, J.R.; Brouillette, C.G.; Hunt, J.F.

J. Biol. Chem.

293

17685-17704

Links to other databases for 7-methyl-GTP

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Show Links (1 entry)

ChEBI

PubChem

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