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Ligand 5beta-Pregnan-3alpha,21-diol-20-one Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 1 H3 4 O3
5beta-Pregnan-3alpha,21-diol-20-one
CYKYBWRSLLXBOW-DATPGIFZSA-N
5beta-pregnane-3alpha,21-diol-20-one
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+ = ?
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5beta-pregnane-3alpha,21-diol-20-one + NAD+ = 5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
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5beta-pregnan-3alpha,21-diol-20-one + NAD+ = 5beta-pregnan-21-ol-3,20-dione + NADH
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Product in Enzyme-catalyzed Reactions (1 result)
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5alpha-pregnane-21-ol-3,20-dione + NADPH = 5beta-pregnane-3alpha,21-diol-20-one + NADP+
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
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0.017
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at pH 7.4 and 37°C
KM Value (1 result)
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0.0026
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at pH 7.4 and 37°C
IC50 Value (1 result)
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References & Links Literature References (5)
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Selective inhibition of sheep kidney 11beta-hydroxysteroid dehydrogenase isoform 2 activity by 5alpha-reduced (but not 5beta) derivates of adrenocorticosteroids
1997
Latif, S.A.; Sheff, M.F.; Ribeiro, C.E.; Morris, D.J.
Steroids
62
230-237
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Stereochemistry of hydrogen loss during C-21 dehydroxylation of tetrahydrodeoxycorticosterone by Eubacterium lentum
1989
Holland, H.L.; Ninniss, R.W.; Brown, F.M.
Can. J. Chem.
67
1590-1595
Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney
1989
Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
J. Biochem.
106
633-638
Demonstration of 3alpha(17beta)-hydroxysteroid dehydrogenase distinct from 3alpha-hydroxysteroid dehydrogenase in hamster liver
1990
Ohmura, M.; Hara, A.; Nakagawa, M.; Sawada, H.
Biochem. J.
266
583-589
Substrate specificity and inhibitor sensitivity of rabbit 20alpha-hydroxysteroid dehydrogenase
2013
Endo, S.; Arai, Y.; Hara, A.; Kitade, Y.; Bunai, Y.; El-Kabbani, O.; Matsunaga, T.
Biol. Pharm. Bull.
36
1514-1518
Links to other databases for 5beta-Pregnan-3alpha,21-diol-20-one