Ligand 5beta-Pregnan-3alpha,21-diol-20-one

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Basic Ligand Information

Molecular Structure
Picture of 5beta-Pregnan-3alpha,21-diol-20-one (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H34O3
5beta-Pregnan-3alpha,21-diol-20-one
CYKYBWRSLLXBOW-DATPGIFZSA-N
Synonyms:
5beta-pregnane-3alpha,21-diol-20-one

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+ = ?
show the reaction diagram
-
5beta-pregnane-3alpha,21-diol-20-one + NAD+ = 5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
show the reaction diagram
-
5beta-pregnan-3alpha,21-diol-20-one + NAD+ = 5beta-pregnan-21-ol-3,20-dione + NADH
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5alpha-pregnane-21-ol-3,20-dione + NADPH = 5beta-pregnane-3alpha,21-diol-20-one + NADP+
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.003 mM
-
not inhibitory
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.017
-
at pH 7.4 and 37°C
0.633
-
-
0.367
-
-

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0026
-
at pH 7.4 and 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.003
-
IC50: 0.003 mM

References & Links

Links to other databases for 5beta-Pregnan-3alpha,21-diol-20-one

ChEBI
PubChem
-
PubChem