Ligand 4-Hydroxy-2-oxobutanoate

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 4-Hydroxy-2-oxobutanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O4
4-Hydroxy-2-oxobutanoate
NWVVVBRKAWDGAB-UHFFFAOYSA-N
Synonyms:
(4S)-4-hydroxy-2-oxobutanoate, 2-Keto-4-hydroxybutyrate, 2-oxo-4-hydroxybutyric acid, 4-hydroxy-2-oxobutanoic acid, 4-hydroxy-2-oxobutyrate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-Keto-4-hydroxybutyrate = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-homoserine + H2O + NAD+ = 4-hydroxy-2-oxobutanoate + NH3 + NADH
show the reaction diagram
-
-
L-homoserine + H2O + NAD+ = 4-hydroxy-2-oxobutanoate + NH3 + NADH
show the reaction diagram
-
-
L-homoserine + H2O + O2 = 2-oxo-4-hydroxybutyric acid + NH3 + H2O2
show the reaction diagram
-
-
L-homoserine + 2-oxoglutarate = 4-hydroxy-2-oxobutyrate + L-glutamate
show the reaction diagram
-
-
L-homoserine + glyoxylate = 4-hydroxy-2-oxobutanoate + glycine
show the reaction diagram
-
-
L-aspartate 4-semialdehyde + L-homoserine = L-2,4-diaminobutanoate + 4-hydroxy-2-oxobutanoic acid
show the reaction diagram
-
-
Pyruvate + formaldehyde = 2-Keto-4-hydroxybutyrate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive with respect to DL-4-carboxy-4-hydroxy-2-oxoadipate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.1
-
-

References & Links

Links to other databases for 4-Hydroxy-2-oxobutanoate

ChEBI
PubChem
-
PubChem