Ligand 3,5-diiodo-4-hydroxyphenylpyruvate
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Basic Ligand Information
Molecular Structure

C9H6I2O4
3,5-diiodo-4-hydroxyphenylpyruvate
TZPLBTUUWSVGCY-UHFFFAOYSA-N
(Diiodohydroxyphenyl)pyruvate, 3-(3,5-Diiodo-4-hydroxyphenyl)-2-oxopropanoate, 3-(3,5-Diiodo-4-hydroxyphenyl)pyruvate, 4-hydroxy-3,5-diiodophenylpyruvate
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH = 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+
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(Diiodohydroxyphenyl)pyruvate = ?
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Product in Enzyme-catalyzed Reactions (4 results)
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
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3,5-diiodo-L-tyrosine + oxaloacetate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-aspartate
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3,5-diiodo-D-tyrosine + 2-oxoglutarate = 3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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0.25 mM, 50% inhibition, competitive
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Enzyme Kinetic Parameters
KM Value (2 results)
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References & Links
Literature References (6)
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Mechanistic and stereochemical study of phenylpyruvate tautomerase
1993
Pirrung, M.C.; Chen, J.; Rowley, E.G.; McPhall, A.T.
J. Am. Chem. Soc.
115
7103-7110
A description of human aromatic alpha-keto acid reductase
1982
Donald, L.J.
Ann. Hum. Genet.
46
299-306
Purification, characterization and identification of aromatic 2-oxo acid reductase
1977
Takada, Y.; Noguchi, T.; Kido, R.
Life Sci.
20
609-616
Isolation and properties of aromatic alpha-keto acid reductase
1966
Zannoni, V.G.; Weber, W.W.
J. Biol. Chem.
241
1340-1344
Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874
1982
Lindstedt, S.; Rundgren, M.
J. Biol. Chem.
257
11922-11931
Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria
1967
Nakano, M.
J. Biol. Chem.
242
73-81
Links to other databases for 3,5-diiodo-4-hydroxyphenylpyruvate