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Ligand trans-dec-2-enoyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.2.27

2-trans-decenoyl-CoA + H2O = 2-trans-decenoate + CoA

646200

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.119

(3R)-3-hydroxydecanoyl-CoA = (2E)-2-decenoyl-CoA + H2O

0

-

Substrate in Enzyme-catalyzed Reactions (27 results)

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Show Substrate (27 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.118

trans-2-decenoyl-CoA + NADH + H+ = decanoyl-CoA + NAD+

747579, 764986, 747700

-

1.3.1.38

trans-2-decenoyl-CoA + NADPH = decanoyl-CoA + NADP+

390748, 390760

-

1.3.1.44

2-decenoyl-CoA + NADH + H+ = decanoyl-CoA + NAD+

390807

-

1.3.1.44

trans-2-decenoyl-CoA + NADH = decanoyl-CoA + NAD+

390807, 390808, 390810

-

1.3.1.44

2 entries

1.3.1.8

2-trans-decenoyl-CoA + NAD(P)H = decanoyl-CoA + NADP+

390753, 390758, 390857, 390870, 390810

-

1.3.1.9

trans-2-decenoyl-CoA + NADH + H+ = ?

740080

-

1.3.1.9

trans-2-decenoyl-CoA + NADH + H+ = decanoyl-CoA + NAD+

747579, 747700, 725221

-

1.3.1.9

trans-2-decenoyl-CoA + NADH = decanoyl-CoA + NAD+

390893

-

1.3.1.9

3 entries

3.1.2.2

2-trans-decenoyl-CoA + H2O = CoA + 2-trans-decenoate

646200

-

3.1.2.20

2-trans-decenoyl-CoA + H2O = CoA + 2-trans-decenoate

646200

-

3.1.2.27

2-trans-decenoyl-CoA + H2O = 2-trans-decenoate + CoA

646200

-

4.2.1.119

(2E)-2-decenoyl-CoA + H2O = (3R)-3-hydroxydecanoyl-CoA

649201

-

4.2.1.119

(2E)-decenoyl-CoA + H2O = (3R)-3-hydroxydecanoyl-CoA

714098, 684952, 680715

-

4.2.1.119

2-trans-decenoyl-CoA + H2O = (3R)-3-hydroxydecanoyl-CoA

697692

-

4.2.1.119

dec-2-enoyl-CoA + H2O = (R)-3-hydroxydecanoyl-CoA

33737

-

4.2.1.119

dec-2-enoyl-CoA + H2O = 3-hydroxydecanoyl-CoA

649389

-

4.2.1.119

trans-2-decenoyl-CoA + H2O = (3R)-3-hydroxydecanoyl-CoA

652075

-

4.2.1.119

trans-2-decenoyl-CoA + H2O = (3R)-hydroxydecanoyl-CoA

687485

-

4.2.1.119

trans-2-decenoyl-CoA = (3R)-hydroxydecanoyl-CoA + H2O

687492

-

4.2.1.119

trans-dec-2-enoyl-CoA = ?

696077

-

4.2.1.17

2 trans-2-decenoyl-CoA + 2 H2O = (3S)-3-hydroxydecanoyl-CoA + (3R)-3-hydroxydecanoyl-CoA

730111

-

4.2.1.17

dec-2-enoyl-CoA + H2O = ?

5866

-

4.2.1.17

trans-2-decenoyl-CoA + H2O = (3R)-3-hydroxydecanoyl-CoA

730111

-

4.2.1.17

trans-2-decenoyl-CoA + H2O = (3S)-3-hydroxydecanoyl-CoA

730111

-

4.2.1.17

trans-2-decenoyl-CoA + H2O = (3S)-hydroxydecanoyl-CoA

649889, 649739, 687485, 33718

-

4.2.1.17

trans-decenoyl-CoA + H2O = ?

696077

-

4.2.1.119

9 entries

4.2.1.17

6 entries

4.2.1.74

trans-2-decenoyl-CoA + H2O = (3S)-3-hydroxydecanoyl-CoA

5868, 5869, 698680

-

Product in Enzyme-catalyzed Reactions (16 results)

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Show Product (16 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.34

(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+ = (2E)-2-decaenoyl-CoA + NADP+

0

-

1.3.1.34

2-trans,4-cis-decadienoyl-CoA + NADPH = 2-decenoyl-CoA + NADP+

390724

-

1.3.1.34

2-trans,4-trans-decadienoyl-CoA + NADPH = 2-trans-decenoyl-CoA + NADP+

0

-

1.3.1.34

3 entries

1.3.3.6

decanoyl-CoA + O2 = trans-2-decenoyl-CoA + H2O2

0

-

1.3.8.7

decanoyl-CoA + electron transfer flavoprotein = (2E)-2-decenoyl-CoA + reduced electron transfer flavoprotein

0

-

1.3.8.7

decanoyl-CoA + 2,6-dichlorophenolindophenol = 2-decenoyl-CoA + reduced 2,6-dichorophenolindophenol

0

-

1.3.8.7

decanoyl-CoA + acceptor = 2-decenoyl-CoA + reduced acceptor

391343, 391282, 391201, 391203

-

1.3.8.7

decanoyl-CoA + ferricenium hexafluorophosphate = 2-decenoyl-CoA + ferrocenium hexafluorophosphate

0

-

1.3.8.7

decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol = 2-trans-decenoyl-CoA + reduced acceptor

0, 391275

-

1.3.8.7

decanoyl-CoA + ferrocenium hexafluorophosphate = trans-dec-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate

0

-

1.3.8.8

decanoyl-CoA + phenazine methosulfate = (2E)-2-decenoyl-CoA + reduced phenazine methosulfate

394661, 394662, 391047, 391203, 391272, 391282, 394642, 394667, 391268

-

1.3.8.8

decanoyl-CoA + electron-transfer flavoprotein = 2-decenoyl-CoA + reduced electron-transfer flavoprotein

391325, 391371, 391272, 391282, 394650

-

1.3.8.8

decanoyl-CoA + Meldola's Blue = 2-decenoyl-CoA + reduced meldola blue

391275

-

4.2.1.119

(3R)-3-hydroxydecanoyl-CoA = (2E)-2-decenoyl-CoA + H2O

0

-

4.2.1.119

(R)-3-hydroxydecanoyl-CoA = trans-2-decenoyl-CoA + H2O

0

-

1.3.8.7

6 entries

1.3.8.8

3 entries

4.2.1.119

2 entries

5.3.3.8

3-trans-Decenoyl-CoA = 2-trans-Decenoyl-CoA

0, 3014

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.8.7

medium- and long-chain acyl-CoA dehydrogenase

391283

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (16 results)

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Show Turnover Number (16 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.3.1.9

5.53

-

wild type enzyme, at pH 8.0 and 30°C

740080

1.3.1.9

5.6

-

pH 6.8, 25°C

725221

4.2.1.119

1.3

-

mutant enzyme E366A, pH 5

652075

4.2.1.119

17.9

-

mutant enzyme E366A, pH 8

652075

4.2.1.119

26

-

-

684952

4.2.1.119

105

-

wild type enzyme, pH 5

652075

4.2.1.119

196

-

wild type enzyme, pH 8

652075

4.2.1.119

388

-

recombinant enzyme CtMfe2p(dha+bdelta)

649201

4.2.1.119

1100

-

pH 7.5, 22°C, recombinant full-length enzyme

714098

4.2.1.17

0.0121

-

pH 8.0, 22°C, mutant enzyme E144A/Q162L

649889

4.2.1.17

0.085

-

pH 8.0, 22°C, mutant enzyme E144A

649889

4.2.1.17

0.095

-

pH 8.0, 22°C, mutant enzyme E164A

649889

4.2.1.17

104

-

pH 8.0, 22°C, mutant enzyme Q162A

649889

4.2.1.17

164

-

pH 8.0, 22°C, mutant enzyme Q162M

649889

4.2.1.17

174

-

pH 8.0, 22°C, mutant enzyme Q162L

649889

4.2.1.17

203

-

pH 8.0, 22°C, wild-type enzyme

649889

1.3.1.9

2 entries

4.2.1.119

7 entries

4.2.1.17

7 entries

K_M Value (28 results)

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Show KM Value (28 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.38

0.0071

-

-

390748

1.3.1.38

0.011

-

-

390760

1.3.1.38

0.018

-

recombinant enzyme

390760

1.3.1.38

3 entries

1.3.1.44

0.0893

-

-

390807

1.3.1.9

0.0056

-

pH 6.8, 25°C

725221

1.3.1.9

0.023

-

wild type enzyme, at pH 8.0 and 30°C

740080

4.2.1.119

0.00114

-

pH 7.5, 22°C, recombinant full-length enzyme

714098

4.2.1.119

0.007

-

-

33737

4.2.1.119

0.0081

-

wild type, pH 8

652075

4.2.1.119

0.0089

-

wild type, pH 5

652075

4.2.1.119

0.0092

-

mutant enzyme E366A, pH 5

652075

4.2.1.119

0.0095

-

pH 8.0, 25°C

697692

4.2.1.119

0.013

-

pH 8, 30°C, V130G mutant

649389

4.2.1.119

0.0131

-

mutant enzyme E366A, pH 8

652075

4.2.1.119

0.027

-

pH 8, 30°C, L65A mutant

649389

4.2.1.119

0.042

-

pH 8, 30°C, wild-type

649389

4.2.1.119

4.6

-

-

684952

4.2.1.17

0.0025

-

pH 8.0, 22°C, mutant enzyme E144A/Q162L

649889

4.2.1.17

0.0029

-

pH 8.0, 22°C, mutant enzyme Q162A

649889

4.2.1.17

0.003

-

pH 8.0, 22°C, mutant enzyme E144A

649889

4.2.1.17

0.0039

-

pH 8.0, 22°C, wild-type enzyme

649889

4.2.1.17

0.005

-

pH 8.0, 22°C, mutant enzyme Q162L

649889

4.2.1.17

0.0052

-

pH 8.0, 22°C, mutant enzyme E164A

649889

4.2.1.17

0.0063

-

pH 8.0, 22°C, mutant enzyme Q162M

649889

4.2.1.17

0.008

-

-

700005

4.2.1.17

0.029

-

pH 9.0

5866

4.2.1.74

0.024

-

-

5868

4.2.1.74

0.024

-

25°C

698680

1.3.1.9

2 entries

4.2.1.119

11 entries

4.2.1.17

9 entries

4.2.1.74

2 entries

References & Links

Literature References (54)

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Show Reference (54 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

3014

2154476

DELTA3,DELTA2-Enoyl-CoA isomerases. Characterization of the mitochondrial isoenzyme in the rat

1990

Palossari, P.M.; Kilponen, J.M.; Sormunen, R.T.; Hassinen, I.E.; Hiltunen, J.K.

J. Biol. Chem.

265

3347-3353

5866

833142

Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues

1977

Fong, J.C.; Schulz, H.

J. Biol. Chem.

252

542-547

5868

7278662

Short-chain and long-chain enoyl-CoA hydratases from pig heart muscle

1981

Fong, J.C.; Schulz, H.

Methods Enzymol.

71

390-398

5869

8323290

Purification and characterization of the trifunctional beta-oxidation complex from pig heart mitochondria

1993

Luo, M.J.; He, X.Y.; Sprecher, H.; Schulz, H.

Arch. Biochem. Biophys.

304

266-271

33718

1416981

Inhibition of enoyl-CoA hydratase by long-chain L-3-hydroxyacyl-CoA and its possible effect on fatty acid oxidation

1992

He, X.Y.; Yang, S.Y.; Schulz, H.

Arch. Biochem. Biophys.

298

527-531

33737

8902629

Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase

1996

Jiang, L.L.; Kobayashi, A.; Matsuura, H.; Fukushima, H.; Hashimoto, T.

J. Biochem.

120

624-632

390724

10933894

2,4-Dienoyl-CoA reductase from Escherichia coli is a novel iron-sulfur flavoprotein that functions in fatty acid beta-oxidation

2000

Liang, X.; Thorpe, C.; Schulz, H.

Arch. Biochem. Biophys.

380

373-379

390748

6378898

Studies on the metabolism of unsaturated fatty acids. XIV. Purification and properties of NADPH-dependent trans-2-enoyl-CoA reductase of Escherichia coli K-12

1984

Nishimaki, T.; Yamanaka, H.; Mizugaki, M.

J. Biochem.

95

1315-1321

390753

3977322

Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase

1985

Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.

Arch. Biochem. Biophys.

237

535-544

390758

3058034

Dual action of 2-decynoyl coenzyme A: inhibitor of hepatic mitochondrial trans-2-enoyl coenzyme A reductase and peroxisomal bifunctional protein and substrate for the mitochondrial beta-oxidation system

1988

Nagi, M.N.; Cook, L.; Laguna, J.C.; Cinti, D.L.

Arch. Biochem. Biophys.

267

1-12

390760

10811639

Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs

2000

Das, A.K.; Uhler, M.D.; Hajra, A.K.

J. Biol. Chem.

275

24333-24340

390807

7251572

Purification and characterization of 2-enoyl-CoA reductase of Mycobacterium smegmatis

1981

Shimakata, T.; Kusaka, T.

J. Biochem.

89

1075-1080

390808

7451405

Involvement of one of two enoyl-CoA hydratases and enoyl-CoA reductase in the acetyl-CoA-dependent elongation of medium chain fatty acids by Mycobacterium smegmatis

1980

Shimakata, T.; Fujita, Y.; Kusaka, T.

J. Biochem.

88

1051-1058

390810

6146525

Fatty acid synthesis in mitochondria of Euglena gracilis

1984

Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.

Eur. J. Biochem.

142

121-126

390857

4404888

On the mechanism of malonyl-CoA independent fatty acid synthesis. II. Isolation, properties and subcellular location of trans-2,3-hexenoyl-CoA and trans-2,3-decenoyl-CoA reductase

1972

Podack, E.R.; Seubert, W.

Biochim. Biophys. Acta

280

235-247

390870

3994691

Purification and characterization of 2-enoyl-CoA-reductase from bovine liver

1985

Cvetanovic, M.; Moreno de la Garza, M.; Dommes, V.; Kunau, W.H.

Biochem. J.

227

49-56

390893

10521269

Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis

1999

Parikh, S.; Moynihan, D.P.; Xiao, G.; Tonge, P.J.

Biochemistry

38

13623-13634

391047

2914148

Compartmentation of dicarboxylic acid beta-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids

1989

Suzuki, H.; Yamada, J.; Watanabe, T.; Suga, T.

Biochim. Biophys. Acta

990

25-30

391201

3597357

Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver

1987

Finocchiaro, G.; Ito, M.; Tanaka, K.

J. Biol. Chem.

262

7982-7989

391203

6401712

Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase

1983

Ikeda, Y.; Dabrowski, C.; Tanaka, K.

J. Biol. Chem.

258

1066-1076

391268

4084576

Spectroscopic analysis of the interaction of rat liver short-chain, medium-chain, and long-chain acyl coenzyme A dehydrogenases with acyl coenzyme A substrates

1985

Ikeda, Y.; Okamura-Ikeda, K.; Tanaka, K.

Biochemistry

24

7192-7199

391272

3968063

Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme

1985

Ikeda, Y.; Okamura-Ikeda, K.; Tanaka, K.

J. Biol. Chem.

260

1311-1325

391275

6546382

Purification and properties of acyl coenzyme A dehydrogenases from bovine liver. Formation of 2-trans,4-cis-decadienoyl coenzyme A

1984

Dommes, V.; Kunau, W.H.

J. Biol. Chem.

259

1789-1797

391282

7334008

Purification and properties of rat liver acyl-CoA dehydrogenases and electron transfer flavoprotein

1981

Furuta, S.; Miyazawa, S.; Hashimoto, T.

J. Biochem.

90

1739-1750

391283

7059177

Separation, properties, and regulation of acyl coenzyme A dehydrogenases from bovine heart and liver

1982

Davidson, B.; Schulz, H.

Arch. Biochem. Biophys.

213

155-162

391325

-

Fatty acid oxidation in cultured skin fibroblasts from patients with inherited disorders of fatty acid metabolism: studies on the specificity of acyl-CoA dehydrogenases

1987

Chalmers, R.A.; English, N.

Biochem. Soc. Trans.

15

489-491

391343

6139087

Peroxisomal fatty acyl-coenzyme A oxidation in chicken liver

1983

Ishii, H.; Ishii, S.; Kazama, M.; Suga, T.

Arch. Biochem. Biophys.

226

484-491

391371

9182995

Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation

1997

Eder, M.; Krautle, F.; Dong, Y.; Vock, P.; Kieweg, V.; Kim, J.J.; Strauss, A.W.; Ghisla, S.

Eur. J. Biochem.

245

600-607

394642

3651489

Participation of peroxisomes in the metabolism of xenobiotic acyl compounds: comparison between peroxisomal and mitochondrial beta-oxidation of omega-phenyl fatty acids in rat liver

1987

Yamada, J.; Ogawa, S.; Horie, S.; Watanabe, T.; Suga, T.

Biochim. Biophys. Acta

921

292-301

394650

13319294

On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A

1956

Hauge, J.G.; Crane, F.L.; Beinert, H.

J. Biol. Chem.

219

727-733

394661

8155643

Identification of the catalytic base in long chain acyl-CoA dehydrogenase

1994

Djordjevic, S.; Dong, Y.; Paschke, R.; Frerman, F.E.; Strauss, A.W.; Kim, J.J.

Biochemistry

33

4258-4264

394662

7769092

Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients

1995

Aoyama, T.; Souri, M.; Ushikubo, S.; Kamijo, T.; Yamaguchi, S.; Kelley, R.I.; Rhead, W.J.; Uetake, K.; Tanaka, K.; Hashimoto, T.

J. Clin. Invest.

95

2465-2473

394667

10198089

Identification, separation, and characterization of acyl-coenzyme A dehydrogenases involved in mitochondrial beta-oxidation in higher plants

1999

Bode, K.; Hooks, M.A.; Couee, I.

Plant Physiol.

119

1305-1314

646200

11673457

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism

2002

Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.

J. Biol. Chem.

277

1128-1138

649201

12832794

Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2

2003

Koski, M.K.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T.

Acta Crystallogr. Sect. D

59

1302-1305

649389

12902277

Alteration of chain length substrate specificity of Aeromonas caviae R-enantiomer-specific enoyl-coenzyme A hydratase through site-directed mutagenesis

2003

Tsuge, T.; Hisano, T.; Taguchi, S.; Doi, Y.

Appl. Environ. Microbiol.

69

4830-4836

649739

12106015

Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity

2002

Kiema, T.R.; Taskinen, J.P.; Pirilae, P.L.; Koivuranta, K.T.; Wierenga, R.K.; Hiltunen, J.K.

Biochem. J.

367

433-441

649889

10074351

Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1

1999

Kiema, T.R.; Engel, C.K.; Schmitz, W.; Filppula, S.A.; Wierenga, R.K.; Hiltunen, J.K.

Biochemistry

38

2991-2999

652075

10671535

Human peroxisomal multifunctional enzyme type 2: site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity

2000

Qin, Y.M.; Haapalainen, A.M.; Kilpelainen, S.H.; Marttila, M.S.; Koski, M.K.; Glumoff, T.; Novikov, D.K.; Hiltunen, J.K.

J. Biol. Chem.

275

4965-4972

680715

16982622

Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana

2006

Goepfert, S.; Hiltunen, J.K.; Poirier, Y.

J. Biol. Chem.

281

35894-35903

684952

-

Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis

1997

Qin, Y.; Haapalainen, A.M.; Conry, D.; Cuebas, D.A.; Hiltunen, J.K.; Novikov, D.K.

Biochem. J.

328

377-382

687485

2760034

Epimerization of 3-hydroxyacyl-CoA esters in rat liver. Involvement of two 2-enoyl-CoA hydratases

1989

Hiltunen, J.K.; Palosaari, P.M.; Kunau, W.H.

J. Biol. Chem.

264

13536-13540

687492

10497229

Yeast peroxisomal multifunctional enzyme: (3R)-hydroxyacyl-CoA dehydrogenase domains A and B are required for optimal growth on oleic acid

1999

Qin, Y.M.; Marttila, M.S.; Haapalainen, A.M.; Siivari, K.M.; Glumoff, T.; Hiltunen, J.K.

J. Biol. Chem.

274

28619-28625

696077

9003397

Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization

1997

Qin, Y.M.; Poutanen, M.H.; Helander, H.M.; Kvist, A.P.; Siivari, K.M.; Schmitz, W.; Conzelmann, E.; Hellman, U.; Hiltunen, J.K.

Biochem. J.

321

21-28

697692

1879422

Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA

1991

Engeland K, Kindl H.

Eur. J. Biochem.

200

171-178

698680

4828315

Long chain enoyl coenzyme A hydratase from pig heart

1974

Schulz, H.

J. Biol. Chem.

249

2704-2709

700005

7024730

Fatty acid oxidation complex from Escherichia coli

1981

Binstock, J.F.; Schulz, H.

Methods Enzymol.

71

403-411

714098

21320074

Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics

2011

Haataja, T.J.; Koski, M.K.; Hiltunen, J.K.; Glumoff, T.

Biochem. J.

435

771-781

725221

21393229

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei

2011

Liu, N.; Cummings, J.E.; England, K.; Slayden, R.A.; Tonge, P.J.

J. Antimicrob. Chemother.

66

564-573

730111

23906801

A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific analysis of enoyl-coenzyme A hydratases/isomerases

2013

Abdel-Mawgoud, A.; Lepine, F.; Deziel, E.

J. Chromatogr. A

1306

37-43

740080

27136302

Selectivity of pyridone- and diphenyl ether-based inhibitors for the Yersinia pestis FabV enoyl-ACP reductase

2016

Neckles, C.; Pschibul, A.; Lai, C.T.; Hirschbeck, M.; Kuper, J.; Davoodi, S.; Zou, J.; Liu, N.; Pan, P.; Shah, S.; Daryaee, F.; Bommineni, G.R.; Lai, C.; Simmerling, C.; Kisker, C.; Tonge, P.J.

Biochemistry

55

2992-3006

747579

-

The nonenzymatic activation of isoniazid by MnIII-pyrophosphate in the presence of NADH produces the inhibition of the enoyl-ACP reductase InhA from Mycobacterium tuberculosis

2001

Nguyen, M.; Quemard, A.; Marrakchi, H.; Bernadou, J.; Meunier, B.

Chemistry

4

35-40

747700

25218910

Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis

2014

Pedgaonkar, G.; Sridevi, J.; Jeankumar, V.; Saxena, S.; Devi, P.; Renuka, J.; Yogeeswari, P.; Sriram, D.

Eur. J. Med. Chem.

86

613-627

764986

32152525

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening

2020

Taira, J.; Umei, T.; Inoue, K.; Kitamura, M.; Berenger, F.; Sacchettini, J.C.; Sakamoto, H.; Aoki, S.

J. Antibiot.

73

372-381

Links to other databases for trans-dec-2-enoyl-CoA

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