Ligand valproic acid

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of valproic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H16O2
valproic acid
NIJJYAXOARWZEE-UHFFFAOYSA-N
Synonyms:
2-propylpentanoic acid, dipropylacetate, valporic acid, Valproate

Show all pahtways known for Show all pathways known for valproic acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
300 mg/kg treatment increases MTHFR promoter activity 2.5fold and MTHFR mRNA and protein 3.7fold
-

Inhibitor in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
less than 17% inhibition
-
poor
-
50 mM causes 20-46% inhibition
-
65.4% inhibition at 0.01 mM
-
arylesterase activity is decreased after 60 days of valproic acid treatment
-
reduced activity in microsomes and mitochondria
-
reduced activity in microsomes and mitochondria
-
200-600 mg/kg
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.5
-
pH 9.9
0.564
-
pH and temperature not specified in the publication
0.21
-
brain, post mortem

IC50 Value (4 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.035
-
pH 6.0
0.0501
-
pH 7.2, temperature not specified in the publication

References & Links

Links to other databases for valproic acid

ChEBI
PubChem
ChEBI
PubChem