Ligand 15alpha-hydroxytestosterone
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Basic Ligand Information
Molecular Structure

C19H28O3
15alpha-hydroxytestosterone
KYGUQDTWUBBBSD-MJVYMRHDSA-N
15alpha,17beta-Dihydroxy-4-androsten-3-one, 15alpha,17beta-dihydroxyandrost-4-en-3-one
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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15alpha-hydroxytestosterone + NAD+ = 15alpha-hydroxyandrost-4-ene-3,17-dione + NADH
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Product in Enzyme-catalyzed Reactions (2 results)
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androst-4-ene-3,17-dione + AH2 + O2 = 17beta-hydroxyandrost-4-en-3-one + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta,17beta-dihydroxyandrost-4-en-3-one + 11alpha,17beta-dihydroxyandrost-4-en-3-one + 15alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O
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testosterone + reduced acceptor + O2 = 15alpha-hydroxytestosterone + 15beta-hydroxytestosterone + 2beta-hydroxytestosterone + acceptor + H2O
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Enzyme Kinetic Parameters
References & Links
Literature References (1)
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Isolation of novel microbiol 3alpha-, 3beta, and 17beta-hydroxysteroid dehydrogenases
1985
Payne, D.W.; Talalay, P.
J. Biol. Chem.
260
13648-13655
Links to other databases for 15alpha-hydroxytestosterone