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Ligand O-ureido-D-serine

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for O-ureido-D-serine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.3.5

O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + ammonia + ADP + phosphate

721306

-

6.3.3.5

O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate

771055

-

6.3.3.5

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.1.19

O-ureido-L-serine = O-ureido-D-serine

-

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.1.19

O-ureido-D-serine = O-ureido-L-serine

774852

-

6.3.3.5

O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + ammonia + ADP + phosphate

721306, 721300

-

6.3.3.5

O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate

771055

-

6.3.3.5

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.1.19

O-ureido-L-serine = O-ureido-D-serine

-

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.1.1.19

29

-

pH 7.9, 30°C

723316

6.3.3.5

2200

-

pH 8.0, 30°C

721306

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.1.1.19

17

-

pH 7.9, 30°C

723316

6.3.3.5

10

-

pH 8.0, 30°C

721306

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

721300

20086163

Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae

2010

Kumagai, T.; Koyama, Y.; Oda, K.; Noda, M.; Matoba, Y.; Sugiyama, M.

Antimicrob. Agents Chemother.

54

1132-1139

721306

23529730

. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway

2013

Uda, N.; Matoba, Y.; Kumagai, T.; Oda, K.; Noda, M.; Sugiyama, M

Antimicrob. Agents Chemother.

57

2603-2612

723316

22307920

Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine

2012

Dietrich, D.; van Belkum, M.J.; Vederas, J.C.

Org. Biomol. Chem.

10

2248-2254

771055

31793174

Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for D-cycloserine biosynthesis

2020

Matoba, Y.; Uda, N.; Kudo, M.; Sugiyama, M.

FEBS J.

287

2763-2778

774852

29362754

PLP-independent racemization Mechanistic and mutational studies of O -ureidoserine racemase (DcsC)

2018

Ahn, Y.; Fischer, C.; Van Belkum, M.; Vederas, J.

Org. Biomol. Chem.

16

1126-1133

Links to other databases for O-ureido-D-serine

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Show Links (1 entry)