Ligand 4-hydroxy-2-oxoheptane-1,7-dioate
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Basic Ligand Information
C7H10O6
4-hydroxy-2-oxoheptane-1,7-dioate
HNOAJOYERZTSNK-UHFFFAOYSA-N
(4RS)-4-hydroxy-2-oxoheptane-1,7-dioate, 2-oxo-4-hydroxyhepta-1,7-dioate, 4-hydroxy-2-ketoheptane-1,7-dioate, 4-hydroxy-2-oxo-1,7-heptanedioate, 4-hydroxy-2-oxo-heptanedioate, 4-hydroxy-2-oxoheptanedioate
Related pathways
MetaCyc
4-hydroxyphenylacetate degradation
Show all BRENDA pathways known for 4-hydroxy-2-oxoheptane-1,7-dioate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)
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4-hydroxy-2-oxo-heptanedioate = pyruvate + succinic semialdehyde
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4-hydroxy-2-oxoheptane-1,7-dioate = pyruvate + succinate semialdehyde
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4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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pyruvate + succinic semialdehyde = 4-hydroxy-2-oxo-1,7-heptanedioate
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Substrate in Enzyme-catalyzed Reactions (5 results)
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4-hydroxy-2-ketoheptane-1,7-dioate = pyruvate + succinic semialdehyde
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4-hydroxy-2-oxo-heptanedioate = pyruvate + succinic semialdehyde
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4-hydroxy-2-oxoheptane-1,7-dioate = pyruvate + succinate semialdehyde
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4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
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4-hydroxy-2-oxoheptane-1,7-dioate = ?
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Product in Enzyme-catalyzed Reactions (2 results)
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pyruvate + succinic semialdehyde = 4-hydroxy-2-oxo-1,7-heptanedioate
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pyruvate + succinic semialdehyde = (4RS)-4-hydroxy-2-oxoheptane-1,7-dioate
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (5 results)
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0.54
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data for Mg2+-activated YfaU
299
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data for Ni2+-activated YfaU
361.5
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using H2O as solvent, in the presence of 0.5 mM Co2+, at pH 8.0 and 25°C
0.54
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pH 8.0, 25°C, Mg2+-activated
299
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pH 8.0, 25°C, Ni2+-activated
KM Value (5 results)
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0.1
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data for Ni2+-activated YfaU
0.15
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data for Mg2+-activated YfaU
0.35
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using H2O as solvent, in the presence of 0.5 mM Co2+, at pH 8.0 and 25°C
0.1
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pH 8.0, 25°C, Ni2+-activated
0.15
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pH 8.0, 25°C, Mg2+-activated
References & Links
Literature References (4)
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Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12
2008
Rea, D.; Hovington, R.; Rakus, J.F.; Gerlt, J.A.; Fueloep, V.; Bugg, T.D.; Roper, D.I.
Biochemistry
47
9955-9965
Purification and biochemical characterization of a pyruvate-specific class II aldolase, HpaI
2005
Wang, W.; Seah, S.Y.
Biochemistry
44
9447-9455
Structure and mechanism of HpcH: a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli
2007
Rea, D.; Fulop, V.; Bugg, T.D.; Roper, D.I.
J. Mol. Biol.
373
866-876
Crystal structure of reaction intermediates in pyruvate class II aldolase: substrate cleavage, enolate stabilization, and substrate specificity
2012
Coincon, M.; Wang, W.; Sygusch, J.; Seah, S.Y.
J. Biol. Chem.
287
36208-36221
Links to other databases for 4-hydroxy-2-oxoheptane-1,7-dioate
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