Ligand 3-pyridinealdehyde-NAD+

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Basic Ligand Information

Molecular Structure
Picture of 3-pyridinealdehyde-NAD+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H26N6O14P2
3-pyridinealdehyde-NAD+
KFEUJDWYNGMDBV-LODBTCKLSA-N
Synonyms:
3-pyridinaldehyde adenine dinucleotide, 3-pyridine aldehyde-NAD, 3-pyridinealdehyde-NADH, 3-pyridine aldehyde NADH, 3-pyridinecarboxaldehyde-NAD+, 3-pyridinecarboxaldehyde-NADH, 3-pyridinecarboxaldehyde adenine dinucleotide, deaminopyridinealdehydeadenine dinucleotide, deaminopyridinealdehyde adenine dinucleotide, pyridine-3-aldehyde adenine dinucleotide, pyridine 3-aldehyde adenine dinucleotide, pyridine aldehyde-NAD+, pyridinealdehyde-NAD+, pyridinealdehyde-NADH

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridine 3-aldehyde adenine dinucleotide + L-malate = ?
show the reaction diagram
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xanthine + pyridinealdehyde-NAD+ + H2O = urate + pyridinealdehyde-NADH
show the reaction diagram
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formate + 3-pyridinecarboxaldehyde-NAD+ = CO2 + 3-pyridinecarboxaldehyde-NADH
show the reaction diagram
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pyridine-3-aldehyde adenine dinucleotide + NAD+ + H2O = pyridine-3-carboxylate adenine dinucleotide + NADH
show the reaction diagram
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L-Ala + H2O + 3-pyridinealdehyde-NAD+ = ?
show the reaction diagram
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L-phenylalanine + H2O + 3-pyridinealdehyde-NAD+ = phenylpyruvate + NH3 + 3-pyridinealdehyde-NADH
show the reaction diagram
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L-Leu + H2O + 3-pyridinealdehyde-NAD+ = 4-methyl-2-oxopentanoate + NH3 + 3-pyridinealdehyde-NADH
show the reaction diagram
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NADPH + pyridine aldehyde-NAD+ = NADP+ + pyridine aldehyde-NADH
show the reaction diagram
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ATP + 3-pyridinealdehyde-NAD+ = ?
show the reaction diagram
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ATP + 3-pyridinealdehyde-NAD+ = ?
show the reaction diagram
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pyridine-3-aldehyde adenine dinucleotide + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xanthine + pyridinealdehyde-NAD+ + H2O = urate + pyridinealdehyde-NADH
show the reaction diagram
-
formate + 3-pyridinecarboxaldehyde-NAD+ = CO2 + 3-pyridinecarboxaldehyde-NADH
show the reaction diagram
-
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L-phenylalanine + H2O + 3-pyridinealdehyde-NAD+ = phenylpyruvate + NH3 + 3-pyridinealdehyde-NADH
show the reaction diagram
-
L-Leu + H2O + 3-pyridinealdehyde-NAD+ = 4-methyl-2-oxopentanoate + NH3 + 3-pyridinealdehyde-NADH
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5.0% of the activity with NAD+
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9.2% of the activity with NAD+ in the reaction with L-Phe
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
NAD+ analogue, activates by binding strongly to activator site, binds weakly to catalytic site
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
40% inhibition
-
0.5 mM, 10% inhibition
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0.02 mM, 77% residual activity in presence of 0.05 mM NAD, pH 7.4
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Enzyme Kinetic Parameters

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.19
-
-
0.19
-
-
50
-
-
0.74
-
37°C, pH 7.5
0.74
-
37°C, pH 7.5

References & Links

Links to other databases for 3-pyridinealdehyde-NAD+

ChEBI
PubChem
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PubChem