Ligand 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione

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Basic Ligand Information

Molecular Structure
Picture of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H16N4O6
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
XKQZIXVJVUPORE-RPDRRWSUSA-N
Synonyms:
4-(1'-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine, 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine, 5-amino-6-(1-D-ribitylamino)-2,4(1H,3H)-pyrimidinedione, 5-amino-6-(1-D-ribitylamino)-2,4-dihydroxypyrimidine, 5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione, 5-Amino-6-(1-D-ribitylamino)uracil, 5-amino-6-(D-ribitylamino)uracil, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidine-dione, 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione, 5-amino-6-ribitylamino-2,4-pyrimidinedione, 6-(1-D-ribitylamino)-5-amino-2,4-dihydroxypyrimidine, 6-(1-D-ribitylamino)-5-aminouracil


Show all pahtways known for Show all BRENDA pathways known for 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (22 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 7.0, 37°C, mutant enzyme F57S
0.0244
-
pH 7.0, 37°C, wild-type enzyme
0.0557
-
pH 7.0, 37°C, mutant enzyme T80V
0.0307
-
pH 7.0, 37°C, mutant enzyme S142L
0.0347
-
pH 7.0, 37°C, mutant enzyme R127H
0.0389
-
pH 7.0, 37°C, mutant enzyme N23S
0.0122
-
pH 7.0, 37°C, mutant enzyme K135A
0.0122
-
pH 7.0, 37°C, mutant enzyme K131R
0.0166
-
pH 7.0, 37°C, mutant enzyme K131N
0.0054
-
pH 7.0, 37°C, mutant enzyme H88K
0.0022
-
pH 7.0, 37°C, mutant enzyme H88A
0.0067
-
isoform RibH1, pH 7.0, 37°C
0.04
-
pH 7.0, 37°C, mutant enzyme F22W
0.0244
-
pH 7.0, 37°C, mutant enzyme F22V
0.0147
-
pH 7.0, 37°C, mutant enzyme F22S
0.0263
-
pH 7.0, 37°C, mutant enzyme F22D
0.0081
-
pH 7.0, 37°C, mutant enzyme F113S
0.0038
-
pH 7.0, 37°C, mutant enzyme E58Q
0.0391
-
pH 7.0, 37°C, mutant enzyme D138A
0.051
-
pH 7.0, 37°C, mutant enzyme A56S
0.0453
-
pH 7.0, 37°C
0.003
-
isoform RibH2, pH 7.0, 37°C
0.0003
-

KM Value (35 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 7.0, 37°C, mutant enzyme T80V
0.0041
-
pH 7.0, 37°C, mutant enzyme H88A
0.147
-
pH 7.0, 37°C, mutant enzyme H88K
0.056
-
pH 7.0, 37°C, mutant enzyme K131N
0.0355
-
pH 7.0, 37°C, mutant enzyme K131R
0.0138
-
pH 7.0, 37°C, mutant enzyme K135A
0.0115
-
pH 7.0, 37°C, mutant enzyme N23S
0.0119
-
pH 7.0, 37°C, mutant enzyme R127H
0.0849
-
pH 7.0, 37°C, mutant enzyme S142L
0.011
-
pH 7.0, 37°C, mutant enzyme F57S
0.0345
-
pH 7.0, 37°C, mutant enzyme W27F
0.003
-
pH 7.0, 37°C, mutant enzyme W27G
0.43
-
pH 7.0, 37°C, mutant enzyme W27H
0.4
-
pH 7.0, 37°C, mutant enzyme W27I
0.23
-
pH 7.0, 37°C, mutant enzyme W27S
0.46
-
pH 7.0, 37°C, mutant enzyme W27Y
0.003
-
pH 7.0, 37°C, wild-type enzyme
pH 7.0, 37°C, mutant enzyme A56S
0.0042
-
37°C, pH 7.0
isoform RibH1, pH 7.0, 37°C
0.0025
-
isoform RibH2, pH 7.0, 37°C
0.02
-
pH 7.0, 37°C
0.004
-
-
0.004
-
pH 7.0, 37°C, mutant enzyme D138A
0.01
-
pH 7.0, 37°C, mutant enzyme E58Q
0.173
-
pH 7.0, 37°C, mutant enzyme F113S
0.278
-
pH 7.0, 37°C, mutant enzyme F22D
0.72
-
pH 7.0, 37°C, mutant enzyme F22S
0.14
-
pH 7.0, 37°C, mutant enzyme F22V
0.0107
-
pH 7.0, 37°C, mutant enzyme F22W
0.00612
-

References & Links

Links to other databases for 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione

ChEBI
PubChem
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PubChem