print visible entries

print all entries

Ligand 10-deoxymethymycin

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for 10-deoxymethymycin

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370

-

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370

-

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = novamethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370

-

1.14.15.33

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.277

TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin

-

-

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370, 714405, 727289, 728177, 727865

-

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370, 714405, 727289, 728177, 727865

-

1.14.15.33

10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = novamethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

725370

-

1.14.15.33

3 entries

Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.277

dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin

-

-

2.4.1.277

TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin

-

-

2.4.1.277

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (5)

top print hide

Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

714405

15530995

The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis

2004

Lee, S.K.; Basnet, D.B.; Choi, C.Y.; Sohng, J.K.; Ahn, J.S.; Yoon, Y.J.

Bioorg. Chem.

32

549-559

725370

16825192

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

2006

Sherman, D.H.; Li, S.; Yermalitskaya, L.V.; Kim, Y.; Smith, J.A.; Waterman, M.R.; Podust, L.M.

J. Biol. Chem.

281

26289-26297

727289

9831532

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae

1998

Xue, Y.; Wilson, D.; Zhao, L.; Liu, H.w.; Sherman, D.H.

Chem. Biol.

5

661-667

727865

19124459

Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae

2009

Li, S.; Ouellet, H.; Sherman, D.H.; Podust, L.M.

J. Biol. Chem.

284

5723-5730

728177

16724858

Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae

2006

Lee, S.K.; Park, J.W.; Kim, J.W.; Jung, W.S.; Park, S.R.; Choi, C.Y.; Kim, E.S.; Kim, B.S.; Ahn, J.S.; Sherman, D.H.; Yoon, Y.J.

J. Nat. Prod.

69

847-849

Links to other databases for 10-deoxymethymycin

top print hide

Show Links (1 entry)