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Ligand 4-deoxy-L-threo-5-hexosulose-uronate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

sulfated glycosaminoglycan metabolism

KEGG

Pentose and glucuronate interconversions

MetaCyc

4-deoxy-L-threo-hex-4-enopyranuronate degradation, chondroitin sulfate degradation I (bacterial), dermatan sulfate degradation I (bacterial), gellan degradation, heparan sulfate degradation, heparin degradation, homogalacturonan degradation, hyaluronan degradation, pectin degradation I, rhamnogalacturonan type I degradation II (bacteria), ulvan degradation more

Show all BRENDA pathways known for 4-deoxy-L-threo-5-hexosulose-uronate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.1.17

5-dehydro-4-deoxy-D-glucuronate = (4S)-4,6-dihydroxy-2,5-dioxohexanoate

727101, 663364

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.172

2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp

0

-

3.2.1.179

beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp

0

-

3.2.1.179

2 entries

3.2.1.180

beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate

0

-

4.2.2.6

4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate

0

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.1.17

5-dehydro-4-deoxy-D-glucuronate = (4S)-4,6-dihydroxy-2,5-dioxohexanoate

727101, 663364

-

Product in Enzyme-catalyzed Reactions (20 results)

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Show Product (20 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.172

2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose

0

-

3.2.1.179

beta-D-4-deoxy-DELTA-4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-GalNAc

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-GalNAc6S

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-GlcNAc

0

-

3.2.1.179

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp

0

-

3.2.1.179

beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp

0

-

3.2.1.180

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine

0

-

3.2.1.180

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate

0

-

3.2.1.180

beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O = 4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylglucosamine

0

-

3.2.1.180

beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate

0

-

4.2.2.6

4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate

0

-

4.2.2.6

acid-soluble pectic acid = 4-deoxy-5-keto-D-glucuronic acid

34106

-

4.2.2.6

digalacturonic acid = 4-deoxy-5-keto-D-glucuronic acid + galacturonic acid

34106

-

4.2.2.6

tetragalacturonic acid = 4-deoxy-5-keto-D-glucuronic acid + ?

34106

-

4.2.2.6

trigalacturonic acid = 4-deoxy-5-keto-D-glucuronic acid + digalacturonic acid + galacturonic acid

34106

-

4.2.2.6

unsaturated digalacturonic acid = 4-deoxy-5-keto-D-glucuronic acid + ?

34106

-

4.2.2.6

unsaturated trigalacturonic acid = 4-deoxy-5-keto-D-glucuronic acid + unsaturated digalacturonic acid

34106

-

3.2.1.179

8 entries

3.2.1.180

4 entries

4.2.2.6

7 entries

Enzyme Kinetic Parameters

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

34106

-

Pectolytic enzymes of exo-types. Part I. Oligogalacturonide transeliminase of a Pseudomonas

1971

Hatanaka, C.; Ozawa, J.

Agric. Biol. Chem.

35

1617-1624

663364

16152643

The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli

2005

Crowther, R.L.; Georgiadis, M.M.

Proteins

61

680-684

727101

21664227

Identification of new protein complexes of Escherichia coli inorganic pyrophosphatase using pull-down assay

2011

Rodina, E.; Vorobieva, N.; Kurilova, S.; Mikulovich, J.; Vainonen, J.; Aro, E.M.; Nazarova, T.

Biochimie

93

1576-1583

Links to other databases for 4-deoxy-L-threo-5-hexosulose-uronate

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Show Links (1 entry)

ChEBI

PubChem