Ligand 20-hydroxyvitamin D3

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Basic Ligand Information

Molecular Structure
Picture of 20-hydroxyvitamin D3 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H44O2
20-hydroxyvitamin D3
IQEQEOBGZMEDBQ-LBRHRNEPSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
20-hydroxyvitamin D3 + NADPH + O2 = 1alpha,20-dihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
vitamin D3 + reduced adrenodoxin + O2 = 20-hydroxyvitamin D3 + oxidized adrenodoxin + H2O
show the reaction diagram
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.14
-
pH 7.4, 37°C, parameters using a kinetic model with substrate binding at two inhibitory sites
0.123
-
in the presence of 0.45% cyclodextrin

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
49
-
pH 7.4, 37°C, parameters using a kinetic model with substrate binding at two inhibitory sites
0.067
-
in the presence of 0.45% cyclodextrin

References & Links

Links to other databases for 20-hydroxyvitamin D3

ChEBI
PubChem
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PubChem