Ligand 5-oxoproline

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Basic Ligand Information

Molecular Structure
Picture of 5-oxoproline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H7NO3
5-oxoproline
ODHCTXKNWHHXJC-VKHMYHEASA-N
Synonyms:
5-L-oxoproline, 5-oxo-L-Pro, 5-oxo-L-proline, L-2-pyrrolidone-5-carboxylate, L-2-pyrrolidone 5-carboxylate, L-5-oxoproline, L-5-pyrrolidone-2-carboxylate, L-pyroglutamate, L-pyroglutaminic acid, Pidolate, pyroglutamate, pyroglutamic acid


Show all pahtways known for Show all BRENDA pathways known for 5-oxoproline

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyroglutamyl-peptide + H2O = pyroglutamate + peptide
show the reaction diagram
glutathione = L-cysteinylglycine + 5-oxo-L-proline
show the reaction diagram
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epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (166 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-L-glutamyl-butirosin B = butirosin B + 5-oxoproline
show the reaction diagram
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ATP + L-Glu = ADP + phosphate + 5-oxoproline
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 27% inhibition
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product inhibition at high concentration
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inhibition of IPTase activity
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weak competitive inhibition of the reaction with ammonia as substrate, no significant inhibition with glutamine as substrate
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3D Structure of Enzyme-Ligand-Complex (PDB) (3639 results)

EC NUMBER
ENZYME 3D STRUCTURE