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Gln = L-5-oxoproline + NH3
-
Gln = pyroglutamate + NH3
-
L-pyrrolidonyl 2-naphthylamide + H2O = 5-oxo-L-proline + 2-naphthylamine
-
N-(4-methyl-2-oxo-2H-chromen-7-yl)-5-oxo-L-prolinamide + H2O = 5-oxo-L-proline + 7-amino-4-methylcoumarin
-
ethyl L-pyroglutamate + H2O = L-pyroglutamate + ethanol
-
L-pyroglutamic acid 2-naphthylamide + H2O = L-pyroglutamate + 2-naphthylamine
-
L-pyroglutamyl p-nitroanilide + H2O = L-pyroglutamate + p-nitroaniline
-
L-pyroglutamyl-7-amido-4-methylcoumarin + H2O = L-pyroglutamate + 7-amino-4-methylcoumarin
-
L-pyroglutamyl-aminoluciferin + H2O = L-pyroglutamate + aminoluciferin
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L-pyroglutamyl-beta-naphthylamide + H2O = L-pyroglutamate + 2-naphthylamine
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L-pyroglutamyl-beta-naphthylamide + H2O = L-pyroglutamate + 2-naphtylamine
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L-pyroglutamyl-beta-naphthylamide + H2O = L-pyroglutamate + beta-naphthylamine
L-pyroglutamyl-beta-naphthylamide + H2O = L-pyroglutamate + beta-naphtylamine
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L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O = L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide
-
L-pyroglutamyl-L-Ala + H2O = L-pyroglutamate + L-Ala
-
L-pyroglutamyl-L-Ile + H2O = L-pyroglutamate + L-Ile
-
L-pyroglutamyl-L-Thr + H2O = L-pyroglutamate + L-Thr
-
L-pyroglutamyl-p-nitroanilide + H2O = L-pyroglutamate + p-nitroaniline
-
N-(4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl)-5-oxopyrrolidine-2-carboxamide + H2O = L-pyroglutamate + [4-[(E)-2-(4-aminophenyl)ethenyl]-3-cyano-5,5-dimethylfuran-2(5H)-ylidene]propanedinitrile
-
pyroglutamic acid-7-amido-4-methylcoumarin + H2O = L-pyroglutamate + 7-amino-4-methylcoumarin
-
L-pyroglutamyl-p-nitroanilide + H2O = L-pyroglutaminic acid + p-nitroaniline
ACE inhibitor + H2O = pyroglutamate + ?
acid-thyroliberin + H2O = pyroglutamate + His-Pro
bombesin + H2O = pyroglutamate + ?
bombesin + H2O = pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
bradykinin potentiator + H2O = pyroglutamate + ?
bradykinin potentiator B + H2O = pyroglutamate + ?
Glu(OMe)2-litorin + H2O = pyroglutamate + ?
leukopyrokinin + H2O = pyroglutamate + ?
litorin + H2O = pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
luliberin + H2O = pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
luteinizing hormone releasing hormone + H2O = pyroglutamate + ?
neurotensin + H2O = pyroglutamate + ?
neurotensin + H2O = pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
physalaemin + H2O = pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
pyroglutamyl-2-naphthylamide + H2O = pyroglutamate + 2-naphthylamine
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pyroglutamyl-4-methylcoumarin 7-amide + H2O = pyroglutamate + 7-amino-4-methylcoumarin
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pyroglutamyl-4-methylcoumaryl-7-amide + H2O = pyroglutamate + 7-amino-4-methylcoumarin
pyroglutamyl-Ala + H2O = pyroglutamate + Ala
-
pyroglutamyl-Arg + H2O = pyroglutamate + Arg
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pyroglutamyl-Asp + H2O = pyroglutamate + Asp
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pyroglutamyl-beta-naphthylamide + H2O = pyroglutamate + beta-naphthylamine
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pyroglutamyl-D-Ala + H2O = pyroglutamate + D-Ala
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pyroglutamyl-D-Leu + H2O = pyroglutamate + D-Leu
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pyroglutamyl-Glu + H2O = pyroglutamate + Glu
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pyroglutamyl-Gly + H2O = pyroglutamate + Gly
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pyroglutamyl-Gly-Ile + H2O = pyroglutamate + Gly-Ile
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pyroglutamyl-His + H2O = pyroglutamate + His
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pyroglutamyl-His-Gly + H2O = pyroglutamate + His-Gly
pyroglutamyl-His-Gly-NH2 + H2O = pyroglutamate + His-Gly-NH2
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pyroglutamyl-His-Pro-Gly + H2O = pyroglutamate + His-Pro-Gly
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pyroglutamyl-His-Pro-Gly-NH2 + H2O = pyroglutamate + His-Pro-Gly-NH2
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pyroglutamyl-Ile + H2O = pyroglutamate + Ile
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pyroglutamyl-Leu + H2O = pyroglutamate + Leu
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pyroglutamyl-Lys + H2O = pyroglutamate + Lys
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pyroglutamyl-Met + H2O = pyroglutamate + Met
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pyroglutamyl-p-nitroanilide + H2O = pyroglutamate + p-nitroaniline
-
pyroglutamyl-peptide + H2O = pyroglutamate + peptide
pyroglutamyl-Phe + H2O = pyroglutamate + Phe
-
pyroglutamyl-Phe-Pro-NH2 + H2O = pyroglutamate + Phe-Pro-NH2
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pyroglutamyl-Ser + H2O = pyroglutamate + Ser
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pyroglutamyl-Thr + H2O = pyroglutamate + Thr
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pyroglutamyl-Trp + H2O = pyroglutamate + Trp
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pyroglutamyl-Tyr + H2O = pyroglutamate + Tyr
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pyroglutamyl-Val + H2O = pyroglutamate + Val
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thyroliberin + H2O = pyroglutamate + His-Pro-NH2
L-5-oxoprolyl 2-naphthylamide + H2O = 2-naphthylamine + 5-oxoproline
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L-pyroglutamyl-beta-naphthylamide + H2O = L-pyroglutamate + 2-naphthylamine
-
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L-pyroglutamyl-L-Tyr-L-Pro-NH2 + H2O = L-pyroglutamate + L-Tyr-L-Pro-NH2
-
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pyroglutamyl-Asn(N-benzyl)-ProNH2 + H2O = L-pyroglutamate + Asn(N-benzyl)-ProNH2
-
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pyroglutamyl-Asn(N-methyl)-ProNH2 + H2O = L-pyroglutamate + Asn(N-methyl)-ProNH2
-
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thyrotrophin-releasing hormone + H2O = L-pyroglutamate + ?
-
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TRH-like peptide + H2O = L-pyroglutamate + ?
-
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pyroglutamyl-7-amido-4-methylcoumarin + H2O = pyroglutamate + 7-amino-4-methylcoumarin
-
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pyroglutamyl-His-Gly + H2O = pyroglutamate + His-Gly
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pyroglutamyl-His-Pro-7-amido-4-methylcoumarin + H2O = pyroglutamate + His-Pro-7-amido-4-methylcoumarin
-
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pyroglutamyl-His-Pro-NH2 + H2O = pyroglutamate + His-Pro-NH2
-
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pyroglutamyl-His-Pro-OH + H2O = pyroglutamate + His-Pro-OH
-
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pyroglutamyl-His-tripeptidyl naphthylamides + H2O = pyroglutamate + His-tripeptidyl naphthylamides
-
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pyroglutamyl-Phe-Pro-NH2 + H2O = pyroglutamate + Phe-Pro-NH2
-
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pyroglutamyl-Phe-Pro-OH + H2O = pyroglutamate + Phe-Pro-OH
-
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pyroglutamyl-thienylalanyl-Pro-NH2 + H2O = pyroglutamate + thienylalanyl-Pro-NH2
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pyroglutamyl-Tyr-Pro-OH + H2O = pyroglutamate + Tyr-Pro-OH
-
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pyroglutamyl-histidyl-prolyl-7-amido-4-methylcoumarin + H2O = pyroglutamic acid + histidyl-prolyl-7-amido-4-methylcoumarin
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thyroliberin + H2O = pyroglutamic acid + His-Pro-NH2
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gamma-L-glutamyl-butirosin B = butirosin B + 5-oxoproline
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gamma-glutamyl-L-alanine = 5-oxo-L-proline + L-alanine
-
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glutathione = L-cysteinylglycine + 5-oxo-L-proline
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alpha-N-acetyl-epsilon-(L-gamma-glutamyl)-L-lysine methyl ester = alpha-N-acetyl-L-lysine + 5-oxo-L-proline
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epsilon-(gamma-L-glutamyl)-D-lysine = D-lysine + 5-oxo-L-proline
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epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
-
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gamma-glutamyldansylcadaverine = dansylcadaverine + 5-oxo-L-proline
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L-gamma-glutamyl-(2S)-2-methylbutylamine = (2S)-2-methylbutylamine + 5-oxo-L-proline
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L-gamma-glutamyl-2-methylbutylamine = 2-methylbutylamine + 5-oxo-L-proline
-
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L-gamma-glutamyl-beta-alanine = beta-alanine + 5-oxo-L-proline
-
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L-gamma-glutamyl-n-butylamine = n-butylamine + 5-oxo-L-proline
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L-gamma-glutamyl-n-propylamine = n-propylamine + 5-oxo-L-proline
-
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L-gamma-glutamylbenzylamine = benzylamine + 5-oxo-L-proline
-
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L-gamma-glutamylcyclopentylamine = cyclopentylamine + 5-oxo-L-proline
-
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L-gamma-glutamyldansylcadaverine = dansylcadaverine + 5-oxo-L-proline
-
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L-gamma-glutamylneohexylamine = neohexylamine + 5-oxo-L-proline
-
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L-gamma-glutamylputrescine = putrescine + 5-oxo-L-proline
-
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L-gamma-glutamylspermidine = spermidine + 5-oxo-L-proline
-
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Nepsilon-(L-gamma-glutamyl)-D-lysine = D-lysine + 5-oxo-L-proline
-
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Nepsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
-
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5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide = 5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
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5-L-glutamyl-L-alanine = 5-L-oxoproline + L-alanine
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5-L-glutamyl-L-alpha-aminobutyrate = 5-L-oxoproline + L-alpha-aminobutyrate
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alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline
-
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alpha-N-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
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gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys = epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
-
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glutathione = L-cysteinylglycine + 5-oxo-L-proline
-
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L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine = (2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
-
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N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine = (2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
-
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(gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid
-
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(gamma-L-glutamyl)-L-serine = 5-oxoproline + L-serine
-
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2-N-(5-L-glutamyl)L-lysine = 5-oxoproline + L-lysine
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5-glutamyl-glutathione = 5-oxoproline + glutathione
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5-L-glutamyl-(+)-3-aminobutyric acid = 5-oxoproline + (+)-3-aminbutyric acid
-
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5-L-glutamyl-(+)-3-aminoisobutyric acid = 5-oxoproline + (+)-3-aminoisobutyric acid
-
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5-L-glutamyl-1-naphthylamide = 5-oxoproline + naphthylamine
-
5-L-glutamyl-5-L-glutamyl-4-nitroanilide = 5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
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5-L-glutamyl-5-L-glutamyl-glycine = 5-oxoproline + 5-L-glutamyl-glycine
-
5-L-glutamyl-5-L-glutamyl-L-alanine = 5-oxoproline + 5-L-glutamyl-L-alanine
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5-L-glutamyl-5-L-glutamyl-L-amino acid = 5-oxoproline + 5-L-glutamyl-L-amino acid
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5-L-glutamyl-5-L-glutamyl-L-glutamate = 5-oxoproline + 5-L-glutamyl-L-glutamate
-
5-L-glutamyl-5-L-glutamyl-L-glutamine = 5-oxoproline + 5-L-glutamyl-L-glutamine
-
5-L-glutamyl-5-L-glutamyl-L-leucine = 5-oxoproline + 5-L-glutamyl-L-leucine
-
5-L-glutamyl-5-L-glutamyl-L-lysine = 5-oxoproline + 5-L-glutamyl-L-lysine
-
5-L-glutamyl-5-L-glutamyl-L-phenylalanine = 5-oxoproline + 5-L-glutamyl-L-phenylalanine
-
5-L-glutamyl-5-L-glutamyl-L-proline = 5-oxoproline + 5-L-glutamyl-L-proline
-
5-L-glutamyl-5-L-glutamyl-L-threonine = 5-oxoproline + 5-L-glutamyl-L-threonine
-
5-L-glutamyl-5-L-glutamyl-L-tyrosine = 5-oxoproline + 5-L-glutamyl-L-tyrosine
-
5-L-glutamyl-5-L-glutamyl-L-valine = 5-oxoproline + 5-L-glutamyl-L-valine
-
5-L-glutamyl-anilide = 5-oxoproline + aniline
-
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5-L-glutamyl-benzylamine = 5-oxoproline + benzylamine
-
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5-L-glutamyl-beta-alanine = 5-oxoproline + beta-alanine
-
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5-L-glutamyl-beta-phenethylamine = 5-oxoproline + beta-phenethylamine
-
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5-L-glutamyl-cyclopentylamine = 5-oxoproline + cyclopentylamine
-
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5-L-glutamyl-cysteine = 5-oxoproline + L-cysteine
-
5-L-glutamyl-ethylamine = 5-oxoproline + ethylamine
-
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5-L-glutamyl-glycine = 5-oxoproline + glycine
-
5-L-glutamyl-L-6-N-benzyloxycarbonyl-L-lysine = 5-oxoproline + L-6-N-benzyloxycarbonyl-L-lysine
-
5-L-glutamyl-L-alanine = 5-oxoproline + L-alanine
-
-
5-L-glutamyl-L-amino acid = 5-oxoproline + L-amino acid
487982, 487979, 487981, 487985, 487978, 487974, 487983, 487975, 487984, 487980, -
-
5-L-glutamyl-L-aspartate = 5-oxoproline + L-aspartate
-
5-L-glutamyl-L-cysteine = 5-oxoproline + L-cysteine
-
5-L-glutamyl-L-glutamate = 5-oxoproline + L-glutamate
-
5-L-glutamyl-L-glutamine = 5-oxoproline + L-glutamine
-
5-L-glutamyl-L-isoleucine = 5-oxoproline + L-isoleucine
-
5-L-glutamyl-L-leucine = 5-oxoproline + L-leucine
-
5-L-glutamyl-L-methionine = 5-oxoproline + L-methionine
-
5-L-glutamyl-L-phenylalanine = 5-oxoproline + L-phenylalanine
-
5-L-glutamyl-L-proline = 5-oxoproline + L-proline
-
5-L-glutamyl-L-tyrosine = 5-oxoproline + L-tyrosine
-
5-L-glutamyl-L-valine = 5-oxoproline + L-valine
-
5-L-glutamyl-methylamine = 5-oxoproline + methylamine
-
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5-L-glutamyl-n-butylamine = 5-oxoproline + butylamine
-
-
5-L-glutamyl-n-propylamine = 5-oxoproline + propylamine
-
-
5-L-glutamyl-neohexylamine = 5-oxoproline + neohexylamine
-
-
5-L-glutamyl-neopentylamine = 5-oxoproline + neopentylamine
-
-
5-L-glutamyl-S-methyl-L-cysteine = 5-oxoproline + S-methyl-L-cysteine
-
D-gamma-glutamyl-O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine = 5-oxoproline + O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
-
-
gamma-glutamyl-Cys + H2O = 5-oxoproline + L-cysteine
-
-
gamma-glutamyl-L-alanine = 5-oxoproline + alanine
-
-
gamma-L-glutamyl-L-amino acid = 5-oxoproline + L-amino acid
-
glutathione = 5-oxoproline + L-Cys-Gly
-
-
L-gamma-glutamyl-L-epsilon-lysine = 5-oxoproline + L-lysine
-
-
Nepsilon-(5-L-glutamyl)-L-lysine = 5-oxoproline + L-lysine
-
ATP + L-Glu = ADP + phosphate + 5-oxoproline
-
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An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro
1983
Browne, P.; O'Cuinn, G.
Eur. J. Biochem.
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Pyroglutamyl peptidase from chicken liver: purification and some properties
1982
Tsuru, D.; Sakabe, K.; Yoshimoto, T.; Fujiwara, K.
J. Pharmacobio-Dyn.
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The substrate specificity of pyrrolidone carboxylyl peptidase from Bacillus amyloliquefaciens
1979
Fujiwara, K.; Kobayashi, R.; Tsuru, D.
Biochim. Biophys. Acta
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Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone
1978
Taylor, W.L.; Dixon, J.E.
J. Biol. Chem.
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Purification and characterization of L-pyrrolidonecarboxylate peptidase from Bacillus amyloliquefaciens
1978
Tsuru, D.; Fujiwara, K.; Kado, K.
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Presence of a particulate thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity in rat liver
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Scharfmann, R.; Morgat, J.L.; Aratan-Spire, S.
Neuroendocrinology
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Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate
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Metabolism in vivo of 5-oxo-L-proline and its inhibition by analogs of 5-oxo-L-proline
1985
Hsu, T.; Meister, A.
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5-Oxo-L-prolinase from Pseudomonas putida
1985
Seddon, A.P.; Li, L.; Meister, A.
Methods Enzymol.
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5-Oxo-L-Prolinase from rat kidney
1985
Meister, A.; Griffith, O.W.; Williamson, J.M.
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Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein
1984
Seddon, A.P.; Li, L.; Meister, A.
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259
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New substrates of 5-oxo-L-prolinase
1982
Williamson, J.M.; Meister, A.
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Effect of sulfhydryl group modification on the activities of 5-oxo-L-prolinase
1982
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Interaction of 5-oxo-L-prolinase with nucleoside triphosphates. Evidence suggesting substrate-dependent conformational change
1982
Griffith, O.W.; Meister, A.
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5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Studies of the chemical mechanism
1981
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Development of gamma-glutamylcysteine synthetase and oxoprolinase in rat kidney
1979
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5-Oxoprolinase (L-pyroglutamate hydrolase) in higher plants
1978
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Dependence of energy coupling on nucleotide base structure in the reaction catalyzed by 5-oxo-L-prolinase
1976
Griffith, O.W.; Meister, A.
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5-Oxo-L-prolinase (L-pyroglutamate hydrolase) purification and catalytic properties
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5-Oxoprolinase from rat kidney, I assay, purification, and determination of kinetic parameters
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Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: Evidence for function of the gamma-glutamyl cycle
1974
Van Der Werf, P.; Stephani, R.A.; Meister, A.
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Isolation of 5-oxoprolinase from a prokaryote
1974
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Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid
1973
Van Der Werf, P.; Stephani, R.A.; Orlowski, M.; Meister, A.
Proc. Natl. Acad. Sci. USA
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Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the gamma-glutamyl cycle
1971
Van Der Werf, P.; Orlowski, M.; Meister, A.
Proc. Natl. Acad. Sci. USA
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The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning
1996
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Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: A potential new target for biochemical modulation of glutathione
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Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells
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56
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Immunohistochemical localization of 5-oxo-L-prolinase, an enzyme of the gamma-glutamyl cycle, in porcine brain microvessels
1999
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445
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Kinetic parameters and tissue distribution of 5-oxo-L-prolinase determined by a fluorimetric assay
1999
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Show all BRENDA pathways known for 5-oxo-L-proline
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