Ligand methylmercury

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Basic Ligand Information

Molecular Structure
Picture of methylmercury (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH3Hg
methylmercury
DBUXSCUEGJMZAE-UHFFFAOYSA-N
Synonyms:
CH3Hg+, methyl mercury

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CH3Hg+ + H+ = CH4 + Hg2+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
MeHg, activation of PLC
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Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
concentration 0.1, 1.0, 20 M, inhibits adenosine deaminase activity in 7- and 60-day-old rats in a concentration-dependent manner, glutathione (50 microM) and dithiothreitol (50 microM) prevent the reduction of adenosine deaminase activity both in cerebral cortex and hippocampus, garlic alcoholic extract (100 microg/ml) abolishes the reduction of adenosine deaminase
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33% inhibition at 0.005 mM
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the growth rates of both the wild-type and ppk/merT-transgenic tobacco callus are largely inhibited by CH3Hg+ in a dose-dependent manner
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3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.043
-
pH 6.8, 25C

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.02
2
adrenal cortex microsomes, pH and temperature not specified in the publication
0.00000796
-
pH 6.0, 37C

References & Links

Links to other databases for methylmercury

ChEBI
PubChem
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PubChem