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Ligand S-aminomethyldihydrolipoylprotein

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.2.10

S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3

485697, 485693, 485696, 391984, 391993

-

2.1.2.10

[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3

719865, 758091, 759778

-

2.1.2.10

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.4.2

glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2

0

-

1.4.4.2

glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2

0

-

1.4.4.2

glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2

0

-

1.4.4.2

3 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.2.10

S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + NH3

485697, 485698, 485693, 391993, 391984, 485696

-

2.1.2.10

S-aminomethyldihydrolipoylprotein + tetrahydropteroyltetraglutamate = dihydrolipoylprotein + 5,10-methylenetetrahydropteroyltetraglutamate + NH3

485698

-

2.1.2.10

[protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3

719865, 758091, 759778

-

2.1.2.10

3 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.4.2

glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2

0

-

1.4.4.2

glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2

0

-

1.4.4.2

glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2

0

-

1.4.4.2

3 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.2.10

0.0037

-

-

485693

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

391984

3143355

Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase

1988

Bourguignon, J.; Neuburger, M.; Douce, R.

Biochem. J.

255

169-178

391993

4460882

Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components

1974

Motokawa, Y.; Kikuchi, G.

Arch. Biochem. Biophys.

164

624-633

485693

7053363

Purification and characterization of chicken liver T-protein, a component of the glycine cleavage system

1982

Okamura-Ikeda, K.; Fujiwara, K.; Motokawa, Y.

J. Biol. Chem.

257

135-139

485696

11286506

Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): A strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)

2001

Toone, J.R.; Applegarth, D.A.; Coulter-Mackie, M.B.; James, E.R.

Mol. Genet. Metab.

72

322-325

485697

12487019

Genomic organization of the murine aminomethyltransferase gene (Amt)

2002

Backofen, B.; Leeb, T.

DNA Seq.

13

179-183

485698

10364177

Identification of the folate binding sites on the Escherichia coli T-protein of the glycine cleavage system

1999

Okamura-Ikeda, K.; Fujiwara, K.; Motokawa, Y.

J. Biol. Chem.

274

17471-17477

719865

20375021

Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism

2010

Okamura-Ikeda, K.; Hosaka, H.; Maita, N.; Fujiwara, K.; Yoshizawa, A.C.; Nakagawa, A.; Taniguchi, H.

J. Biol. Chem.

285

18684-18692

758091

28866761

T-protein is present in large excess over the other proteins of the glycine cleavage system in leaves of Arabidopsis

2018

Timm, S.; Giese, J.; Engel, N.; Wittmiss, M.; Florian, A.; Fernie, A.R.; Bauwe, H.

Planta

247

41-51

759778

28462797

D-Glyceric aciduria does not cause nonketotic hyperglycinemia a historic co-occurrence

2017

Swanson, M.A.; Garcia, S.M.; Spector, E.; Kronquist, K.; Creadon-Swindell, G.; Walter, M.; Christensen, E.; Van Hove, J.L.K.; Sass, J.O.

Mol. Genet. Metab.

121

80-82

Links to other databases for S-aminomethyldihydrolipoylprotein

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Show Links (1 entry)