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Ligand [Skp1-protein]-hydroxyproline

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.229

UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline = UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline

658198

-

2.4.1.229

UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline = UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline

639556, 639555, 639557, 721632

-

2.4.1.229

2 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.229

UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline = UDP + [Skp1-protein]-O-(alpha-N-acetyl-D-glucosaminyl)hydroxyproline

658198

-

2.4.1.229

UDP-N-acetylglucosamine + [Skp1-protein]-hydroxyproline = UDP + [Skp1-protein]-O-(N-acetyl-D-glucosaminyl)hydroxyproline

639555, 639557, 639556, 721632

-

2.4.1.229

UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline = UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline

639556

-

2.4.1.229

3 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.229

0.00056

-

pH 7.8, 30°C

639556

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

639555

12244115

Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of Dictyostelium

2002

van der Wel, H.; Morris, H.R.; Panico, M.; Paxton, T.; Dell, A.; Kaplan, L.; West, C.M.

J. Biol. Chem.

277

46328-46337

639556

10593934

Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium

1999

Teng-umnuay, P.; van der Wel, H.; West, C.M.

J. Biol. Chem.

274

36392-36402

639557

11886837

Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins

2002

West, C.M.; van der Wel, H.; Gaucher, E.A.

Glycobiology

12

17R-27R

658198

15238247

Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways

2004

West, C.M.; van der Wel, H.; Sassi, S.; Gaucher, E.A.

Biochim. Biophys. Acta

1673

29-44

721632

21247092

Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and alpha-N-acetylglucosaminyltransferase enzymes involved in O2 signaling in dictyostelium

2011

van der Wel, H.; Johnson, J.M.; Xu, Y.; Karunaratne, C.V.; Wilson, K.D.; Vohra, Y.; Boons, G.J.; Taylor, C.M.; Bendiak, B.; West, C.M.

Biochemistry

50

1700-1713

Links to other databases for [Skp1-protein]-hydroxyproline

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Show Links (1 entry)