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Ligand (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C7 H8 O4
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate
INCSWYKICIYAHB-WDSKDSINSA-N
(2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate, (5S,6S)-5,6-dihydroxycyclohexa-1,3-diene-1-carboxylate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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(2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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(2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+
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(5S,6S)-5,6-dihydroxycyclohexa-1,3-diene-1-carboxylate + 2-oxoglutarate = (1R,2S,5S,6S)-2-succinyl-5,6-dihydroxycyclohex-3-ene-1-carboxylate + CO2
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Product in Enzyme-catalyzed Reactions (1 result)
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isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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References & Links Literature References (4)
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Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin
1990
Sakaitani, M.; Rusnak, F.; Quinn, N.R.; Tu, C.; Frigo, R.B.; Berchtold, G.A.; Walsh, C.T.
Biochemistry
29
6789-6798
Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
1989
Liu, J.; Duncan, K.; Walsh, C.T
J. Bacteriol.
171
791-798
Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937
2017
Losada, A.A.; Cano-Prieto, C.; Garcia-Salcedo, R.; Brana, A.F.; Mendez, C.; Salas, J.A.; Olano, C.
Microb. Biotechnol.
10
873-885
Alteration of the route to menaquinone towards isochorismate-derived metabolites
2019
Fries, A.; Mazzaferro, L.S.; Gruening, B.; Bisel, P.; Stibal, K.; Buchholz, P.C.F.; Pleiss, J.; Sprenger, G.A.; Mueller, M.
ChemBioChem
20
1672-1677
Links to other databases for (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate