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Ligand S2-

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.49

O-acetyl-L-homoserine + S2- = L-homocysteine + acetic acid

637835

-

2.5.1.49

O-acetyl-L-serine + S2- = L-cysteine + acetic acid

637835

-

2.5.1.49

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.48

O-acetyl-L-homoserine + S2- = L-homocysteine + acetate

637439

-

2.5.1.48

O-phospho-L-homoserine + S2- = L-homocysteine + phosphate

637448, 637449

-

2.5.1.49

O-acetyl-L-homoserine + S2- = L-homocysteine + acetic acid

637835

-

2.5.1.49

O-acetyl-L-serine + S2- = L-cysteine + acetic acid

637835

-

2.5.1.48

2 entries

2.5.1.49

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.7.1

SO32- + FMNH2 = S2- + FMN + H2O

-

-

4.4.1.4

L-cystine = pyruvate + NH4+ + S2- + L-cysteine

-

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.7.4

partial inhibitor

684432

-

2.5.1.47

-

637382

-

3.1.3.2

-

134762

-

3.11.1.1

-

246531

-

6.1.1.16

-

190, 58

-

Metals and Ions (3 results)

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Show Metals Ions (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.7.4

contains a [NiFe4S5] center called cluster C

690057

-

1.2.7.6

Mo-GAPOR expressed in Escherichia coli strain BL21(DE3) is estimated to contain 6.1 g-atoms of acid-labile sulfide per mol of protein

692835

-

2.8.1.6

enhances activity

645605

-

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.5.1.48

0.6

-

pH 7.5, 30°C

637449

2.5.1.49

0.52

-

-

637835

2.5.1.49

0.7

-

-

637835

2.5.1.49

2 entries

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.5.1.47

0.011

-

pH 7.5, 25 C, free enzyme

637382

2.5.1.47

0.11

-

pH 7.5, 25 C, enzyme bound to serine acetyltransferase

637382

2.5.1.47

2 entries

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

58

14693

Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of cysteinyl- and methionyl-tRNA synthetase

1977

Burnell, J.N.; Whatley, F.R.

Biochim. Biophys. Acta

481

266-278

190

16660161

Cysteinyl-tRNA synthetase from Phaseolus aureus. Purification and properties

1977

Burnell, J.N.; Shrift, A.

Plant Physiol.

60

670-674

134762

4750764

Bovine milk acid phosphatase. I. Some kinetic studies and other properties using a partially purified preparation

1973

Andrews, A.T.; Pallavicini, C.

Biochim. Biophys. Acta

321

197-209

246531

4989158

The enzyme cleavage of the carbon-phosphorous bond: purification and properties of phosphonatase

1970

La Nauze, J.M.; Rosenberg, H.; Shaw, D.C.

Biochim. Biophys. Acta

212

332-350

637382

10993149

Effects of bienzyme complex formation of cysteine synthetase from Escherichia coli on some properties and kinetics

2000

Mino, K.; Yamanoue, T.; Sakiyama, T.; Eisaki, N.; Matsuyama, A.; Nakanishi, K.

Biosci. Biotechnol. Biochem.

64

1628-1640

637439

3816790

Purification and characterization of cystathionine gamma-synthase type II from Bacillus sphaericus

1987

Kanzaki, H.; Kobayashi, M.; Nagasawa, T.; Yamada, H.

Eur. J. Biochem.

163

105-112

637448

12232160

Purification and properties of cystathionine gamma-synthase from wheat (Triticum aestivum L.)

1994

Kreft, B.D.; Townsend, A.; Pohlenz, H.D.; Laber, B.

Plant Physiol.

104

1215-1220

637449

7840669

Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts

1995

Ravanel, S.; Droux, M.; Douce, R.

Arch. Biochem. Biophys.

316

572-584

637835

-

Synthesis of selenocystine and selenohomocystine with O-acetylhomoserine sulfhydrylase

1985

Chocat, P.; Esaki, N.; Tanaka, H.; Soda, K.

Agric. Biol. Chem.

49

1143-1150

645605

12471501

Biotin synthase of Bacillus subtilis shows less reactivity than that of Escherichia coli in in vitro reaction systems

2002

Kiyasu, T.; Asakura, A.; Nagahashi, Y.; Hoshino, T.

Arch. Microbiol.

179

26-32

684432

18404747

Implications of a carboxylate-bound C-cluster structure of carbon monoxide dehydrogenase

2008

Lindahl, P.A.

Angew. Chem.

47

4054-4056

690057

18048691

Carbon dioxide activation at the Ni,Fe-cluster of anaerobic carbon monoxide dehydrogenase

2007

Jeoung, J.H.; Dobbek, H.

Science

318

1461-1464

692835

17704226

Glyceraldehyde-3-phosphate ferredoxin oxidoreductase from Methanococcus maripaludis

2007

Park, M.O.; Mizutani, T.; Jones, P.R.

J. Bacteriol.

189

7281-7289

Links to other databases for S2-

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Show Links (1 entry)